Insulin Resistance in Non-Obese Hypertensive Subjects - its Role in Free Fatty Acid Metabolism

Marita, Rosalind; Desai, Beejal; Desai, A; Sawant, Nivedita; Dalal, Kavita

doi:10.1055/s-2007-979805

Cited by 3 publications

(6 citation statements)

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“…We had previously demonstrated the effect of hypertension in causing hyperinsulinaemia in nonobese subjects. 10,11 In the present study, we determined the effect of obesity in normotensive subjects and hypertensive subjects. As a result, the nonobese hypertensive subjects chosen to match the obese group are younger compared to nonobese normotensive subjects (46.9 y vs 55.2 y, Table 1) and both these subjects are still younger compared to nonobese subjects in the previous studies 10,11 (aged 58.6 ± 63.8 y).…”

Section: Discussionmentioning

confidence: 99%

“…10,11 In the present study, we determined the effect of obesity in normotensive subjects and hypertensive subjects. As a result, the nonobese hypertensive subjects chosen to match the obese group are younger compared to nonobese normotensive subjects (46.9 y vs 55.2 y, Table 1) and both these subjects are still younger compared to nonobese subjects in the previous studies 10,11 (aged 58.6 ± 63.8 y). This age difference between nonobese subjects in the present study and in our previous studies could play a role in causing the different levels of hyperinsulinaemia in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…10 For each subject, a detailed medical history, family history, smoking habits, diet and exercise, was recorded to rule out secondary hypertension. They were also subjected to a physical examination, which included height, weight and blood pressure.…”

Section: Subjectsmentioning

confidence: 99%

“…The selection of normotensive and hypertensive subjects was made, as previously described. 10 The study was approved by the Scienti®c Advisory Committee.…”

Section: Subjectsmentioning

confidence: 99%

“…8 Asian Indian subjects are ethnically different from other populations and are reported to have high incidences of diabetes and coronary heart disease (CHD). 9 We had previously shown 10 the presence of IR in nonobese hypertensive subjects, belonging to the Asian Indian community, living in the city of Mumbai, Western India. Subsequently, we had reported that among the nonobese hypertensive subjects, only those subjects with hyperinsulinaemia had abnormal electrocardiographic changes.…”

Section: Introductionmentioning

confidence: 97%

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Insulin resistance in obese hypertensive Asian Indian subjects

et al. 1999

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

“…The selection of normotensive and hypertensive subjects was made, as previously described. 10 The study was approved by the Scienti®c Advisory Committee.…”

Section: Subjectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 3 more Smart Citations

Insulin resistance in obese hypertensive Asian Indian subjects

et al. 1999

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Insulin receptor defects in the erythrocytes of obese Indian women with Acanthosis Nigricans

Marita

Sawant

Mokal

et al. 1997

Clinica Chimica Acta

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Association of insulin resistance to electrocardiographic changes in non obese asian indian subjects with hypertension

Desai

Mokal

et al. 1998

Endocrine Research

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To investigate the relationship between insulin resistance and electrocardiographic changes in hypertension in the absence of confounding influences, plasma glucose and insulin responses to oral glucose were studied in 26 normotensive and 38 hypertensive subjects. Resting ECG was taken and classified into normal or abnormal using the Minnesota code. Among the 38 subjects, 16 had ECG abnormalities. All the hypertensive subjects had normal glucose tolerance. Serum insulin response of hypertensive subjects with ECG changes was 43% higher than those of hypertensive subjects without ECG changes and of normotensive subjects. The ratio AUC glucose/AUC insulin, a measure of insulin sensitivity was significantly reduced in subjects with abnormal ECG. Serum LDL cholesterol was significantly elevated and was the highest in hypertensive subjects with abnormal ECG. The ratio, Total Cholesterol/HDL Cholesterol was elevated to 5.81+/-0.47. I(125)-insulin binding to erythrocytes from 6 normotensive subjects, and 16 hypertensive subjects (8 with and 8 without ECG abnormalities) indicated 50% reduction in insulin receptor number in both the groups of hypertensive subjects compared to normotensive subjects. Multiple logistic regression analysis using mean blood pressure, serum total cholesterol, LDL cholesterol/HDL cholesterol, sex, insulin level at 60 min in OGTT, treatment, serum triglyceride, presence of family history of diabetes, CHD, hypertension and tobacco as independent variables causing ECG changes, revealed correct classification in 84% of cases. Among the variables, insulin level in OGTT contributed the most to ECG abnormalities. The data suggest that in the non obese, non diabetic Asian Indian hypertensive subjects, the presence of electrocardiographic abnormalities might be partly related to hyperinsulinemia or insulin resistance in them.

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Insulin Resistance in Non-Obese Hypertensive Subjects - its Role in Free Fatty Acid Metabolism

Cited by 3 publications

References 0 publications

Insulin resistance in obese hypertensive Asian Indian subjects

Insulin resistance in obese hypertensive Asian Indian subjects

Insulin receptor defects in the erythrocytes of obese Indian women with Acanthosis Nigricans

Association of insulin resistance to electrocardiographic changes in non obese asian indian subjects with hypertension

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