2015
DOI: 10.1002/ejhf.337
|View full text |Cite
|
Sign up to set email alerts
|

Insulin resistance in heart failure: widening the divide between reduced and preserved ejection fraction?

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
4
0

Year Published

2016
2016
2022
2022

Publication Types

Select...
3

Relationship

1
2

Authors

Journals

citations
Cited by 3 publications
(4 citation statements)
references
References 17 publications
0
4
0
Order By: Relevance
“…This suggests IGFBP-7 could compete with insulin receptors for insulin binding and interfere with the physiological response to insulin, contributing to insulin resistance and subsequently to development of diabetes and cardiovascular disease [ 26 ]. Indeed, diabetes mellitus and metabolic syndrome are known to be associated asymptomatic LVDD as well as HFpEF [ 27 – 29 ].…”
Section: Discussionmentioning
confidence: 99%
“…This suggests IGFBP-7 could compete with insulin receptors for insulin binding and interfere with the physiological response to insulin, contributing to insulin resistance and subsequently to development of diabetes and cardiovascular disease [ 26 ]. Indeed, diabetes mellitus and metabolic syndrome are known to be associated asymptomatic LVDD as well as HFpEF [ 27 – 29 ].…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, IR is inversely associated with survival time, independent of body composition, and other established cardiovascular risk factors [29]. Given the high prevalence of IR in HF and its well-described associations with adverse outcomes, interest in IR as a potential therapeutic target and phenotypic divisor in HF has increased in recent years [30]. …”
Section: Metabolic Dysfunction In Heart Failure: More Than Just “An Ementioning
confidence: 99%
“…This epidemiological evidence confirmed the close relationship between heart failure and insulin resistance, suggesting that insulin resistance is an independent risk factor for the development of heart failure. However, patients with heart failure also more commonly have insulin resistance, and patients with heart failure associated with insulin resistance have a worse prognosis [ 14 ]. The occurrence of insulin resistance is time phase- and tissue-specific.…”
Section: Discussionmentioning
confidence: 99%
“…On the one hand, insulin resistance is an independent risk factor for heart failure. On the other hand, insulin resistance is also more common in patients with heart failure, and the prognosis of patients with heart failure accompanied by insulin resistance is worse [ 14 ]. Although insulin resistance alone is not sufficient to cause heart failure, it can weaken the heart's compensatory ability under stress (ischemia, pressure load, or injury).…”
Section: Introductionmentioning
confidence: 99%