Insulin resistance in adolescents with and without overweight of a municipality of Great Florianopolis-SC

Sigwalt, Fabia Rosa; Silva, Rosane Carla Rosendo da

doi:10.5935/0034-7167.20140005

Cited by 6 publications

(3 citation statements)

References 14 publications

(22 reference statements)

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“…Previous studies [4,5] recommend the use of the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) for the identification of IR using cut-off points validated for the population studied. Despite the absence of standardised cut-off points for youths in Brazil [4], studies report that the prevalence of IR ranges from 2.1% to 90.8% among adolescents in different stages of sexual maturity and with different nutritional states [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Independent predictors of insulin resistance in Brazilian adolescents: Results of the study of cardiovascular risk in adolescents–Brazil

et al. 2021

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Considering the current changes in dietary patterns and the increasing prevalence of excess weight throughout the world, several studies have reported insulin resistance, which is a key driver of many chronic diseases, to be an important public health problem in all age groups. Therefore, the aim of the present study was to identify the prevalence and independent predictors of insulin resistance in Brazilian adolescents. A cross-sectional study was conducted with a probabilistic, representative sample of Brazilian adolescents (n = 37,023) who participated in the Study of Cardiovascular Risk in Adolescents. Data were collected on demographic, socioeconomic, lifestyle, anthropometric, and biochemical characteristics as well as antioxidant micronutrient intake (vitamins A, C, E, zinc, and selenium). Insulin resistance was determined using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and classified based on the 75th percentile of the sample distribution. Insulin resistance was detected in 27% of the adolescents and was more prevalent among those aged 12 to 14 years (PR: 1.26 [95%CI: 1.13;1.41]), those residing in the southern and south-eastern regions of the country (PR: 1.47 [95%CI: 1.27;1.70]), those who were physically inactive (PR: 1.12 [95%CI: 1.02;1.23]), and those did not consume alcohol (PR: 1.50 [95%CI: 1.13;1.99]). The prevalence of insulin resistance was 2.5-fold higher among individuals with severe obesity (PR: 2.49 [95%CI: 2.07;3.00]). Waist circumference indicative of cardiovascular risk and high serum triglyceride levels increased the likelihood of insulin resistance (PR: 1.37 [95%CI: 1.19;1.59] and 1.60 [95%CI: 1.45;1.78], respectively). The prevalence of the outcome was higher among adolescents in the lower quartiles of vitamin E intake (p<0.05). In the present study, the prevalence of insulin resistance was high among Brazilian adolescents and we identified sociodemographic, lifestyle, anthropometric, biochemical, and dietary predictors of this outcome.

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Section: Introductionmentioning

confidence: 99%

Independent predictors of insulin resistance in Brazilian adolescents: Results of the study of cardiovascular risk in adolescents–Brazil

et al. 2021

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“…Excessive accumulation of body fat, particularly fat located in the central or visceral region, favors the increase in free fatty acids in the bloodstream, which may impair insulin signaling, decreasing the sensitivity of receptors on cell membranes and resulting in insulin resistance (IR). 3 …”

Section: Introductionmentioning

confidence: 99%

“…Brazilian studies have detected the prevalence of IR in the age range of adolescence and have reported prevalence rates ranging from 6.5% to 90.8% in adolescents with and without excess weight. 3 - 5 The most commonly used methods for determining IR in epidemiological studies are obtained from practical formulas that use fasting glucose and insulin levels, as the Fasting Glucose/Insulin Ratio (FGIR), the Quantitative insulin sensitivity check index (QUICKI) and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), which has been frequently validated in children and adolescents and is recommended as the most sensitive and specific method for assessing insulin sensitivity in this population. 6 - 8 It is noteworthy that one of the important aspects to be observed in the successful application of HOMA-IR index in a given population is the use of specific cutoffs for gender, ethnicity, age and/or sexual maturation level (if used in adolescents).…”

Section: Introductionmentioning

confidence: 99%

Identification of cutoff points for Homeostatic Model Assessment for Insulin Resistance index in adolescents: systematic review

Andrade

Oliveira

Leal

et al. 2016

Revista Paulista de Pediatria (English Edition)

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Objective:To identify cutoff points of the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index established for adolescents and discuss their applicability for the diagnosis of insulin resistance in Brazilian adolescents.Data source:A systematic review was performed in the PubMed, Lilacs and SciELO databases, using the following descriptors: "adolescents", "insulin resistance" and "Receiver Operating Characteristics Curve". Original articles carried out with adolescents published between 2005 and 2015 in Portuguese, English or Spanish languages, which included the statistical analysis using Receiver Operating Characteristics Curve to determine the index cutoff (HOMA-IR) were included.Data synthesis:A total of 184 articles were identified and after the study phases were applied, seven articles were selected for the review. All selected studies established their cutoffs using a Receiver Operating Characteristics Curve, with the lowest observed cutoff of 1.65 for girls and 1.95 for boys and the highest of 3.82 for girls and 5.22 for boys. Of the studies analyzed, one proposed external validity, recommending the use of the HOMA-IR cutoff>2.5 for both genders.Conclusions:The HOMA-IR index constitutes a reliable method for the detection of insulin resistance in adolescents, as long as it uses cutoffs that are more adequate for the reality of the study population, allowing early diagnosis of insulin resistance and enabling multidisciplinary interventions aiming at health promotion of this population.

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Identificação dos pontos de corte do índice Homeostatic Model Assessment for Insulin Resistance em adolescentes: revisão sistemática

Andrade

Oliveira

Leal

et al. 2016

Revista Paulista de Pediatria

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Insulin resistance in adolescents with and without overweight of a municipality of Great Florianopolis-SC

Cited by 6 publications

References 14 publications

Independent predictors of insulin resistance in Brazilian adolescents: Results of the study of cardiovascular risk in adolescents–Brazil

Independent predictors of insulin resistance in Brazilian adolescents: Results of the study of cardiovascular risk in adolescents–Brazil

Identification of cutoff points for Homeostatic Model Assessment for Insulin Resistance index in adolescents: systematic review

Identificação dos pontos de corte do índice Homeostatic Model Assessment for Insulin Resistance em adolescentes: revisão sistemática

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