Insulin resistance highly associates with hypertension in IgA nephropathy

Eiro, Masaaki; Katoh, Takeaki; Sakuma, Yuki; Sakurai, Kenichi; Suzuki, Hirofumi; Asahi, Koichi; Watanabe, Kôji; Watanabe, Takuya

doi:10.5414/cnp59071

Cited by 6 publications

(4 citation statements)

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“…A recent Japanese report did not find a relationship between insulin resistance and renal dysfunction (measured using creatinine clearance and serum creatinine) [15], but rather an association between insulin resistance and hypertension in IgAGN-patients. In that study, insulin resistance was assessed using HOMA-IR, and insulin values were also reported as continuous variables.…”

Section: Discussionmentioning

confidence: 81%

“…In our earlier study, hypertriglyceridaemia and hyperuricaemia at the time of the diagnosis were also found to be associated with a progressive course of IgAGN [14]. Insulin resistance has previously been associated with hypertension in IgAGN [15], but the influence of hyperinsulinaemia on the prognosis of IgAGN has remained unresolved. Therefore, the aim of our study was to examine the association of plasma insulin concentrations with the progression of IgAGN.…”

Section: Introductionmentioning

confidence: 82%

“…glucose tolerance test or clamp were not feasible in the present study design, we chose to use the fasting insulin values and HOMA-IR to assess insulin resistance. Most of the earlier studies on insulin resistance in mild to moderate renal insufficiency have included patients with a variety of kidney diseases, and the number of IgAGN patients in many of those reports has been rather low [6][7][8][9][10]15]. None of the previous studies have provided several years of follow-up information concerning the progression of IgAGN in relation to insulin levels.…”

Section: Discussionmentioning

confidence: 99%

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Insulin resistance and the progression of IgA glomerulonephritis

Kaartinen

Syrjänen

Pörsti

et al. 2007

Nephrology Dialysis Transplantation

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

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Insulin resistance and the progression of IgA glomerulonephritis

Kaartinen

Syrjänen

Pörsti

et al. 2007

Nephrology Dialysis Transplantation

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“…A study by Cattran DC et al reported a higher mean arterial pressure (MAP) and lower corrected creatinine clearance (CrCl) in males than in females with IgAN [ 10 ]. In another study, Eiro et al indicated that male gender was positively correlated with hypertension [ 18 ]. However, Tanaka K et al more frequently observed a high level of urinary red blood cells (≥20/HPF) in female patients [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Gender-related differences in clinicopathological characteristics and renal outcomes of Chinese patients with IgA nephropathy

et al. 2018

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BackgroundThe prognostic effect of gender on immunoglobulin A nephropathy (IgAN) is not clear. We explored gender-related differences in clinicopathological features and renal outcomes in IgAN.MethodsThis was a single-centre retrospective study. Patients were divided into two groups according to gender. The clinicopathological features at biopsy and renal outcomes during the follow-up were collected and analysed. Renal outcomes were defined as the doubling of baseline serum creatinine and end-stage renal disease (ESRD) (estimated glomerular filtration rate < 15 mL/min/1.73 m2, dialysis, or renal transplantation). The prognostic effects of gender were evaluated by Cox regression models.ResultsA total of 988 eligible IgAN patients were enrolled, and the ratio of males to females was 1:1.4. Compared with female patients, male patients had worse renal function, greater proteinuria, a higher prevalence of hypertension, hypertriglyceridaemia and hyperuricaemia, and more severe segmental sclerosis and tubular atrophy/interstitial fibrosis. However, haematuria occurred more frequently in female patients. During a median follow-up time of 48.6 (34.7, 62.7) months, no differences in renal survival rates were noted between the male and female groups. Multivariable Cox regression analyses revealed that gender was not a significant risk factor for renal outcomes after frequency matching of baseline eGFR and serum uric acid (SUA) levels. In addition, male and female patients shared similar risk factors, including a low eGFR and increased proteinuria and segmental sclerosis. In males, however, an elevated proportion of global glomerulosclerosis was also a poor prognostic factor for renal survival.ConclusionsMale IgAN patients presented with worse clinicopathologic features than female patients, but no significant differences were observed in long-term renal survival between male and female patients by eGFR- and SUA level-matching.

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