2007
DOI: 10.1016/j.burns.2006.08.017
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Insulin resistance following thermal injury: An animal study

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Cited by 22 publications
(19 citation statements)
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“…There are only a limited number of studies on insulin signaling defects in skeletal muscle and liver following injury [1012; 2730; 32; 33]. Recently, we found that hepatic insulin resistance develops quickly in rats, within 15 min [11; 12; 27; 30], while skeletal muscle signaling defects develop more slowly (within 60 min) following trauma and hemorrhage [10; 27].…”
Section: Discussionmentioning
confidence: 99%
“…There are only a limited number of studies on insulin signaling defects in skeletal muscle and liver following injury [1012; 2730; 32; 33]. Recently, we found that hepatic insulin resistance develops quickly in rats, within 15 min [11; 12; 27; 30], while skeletal muscle signaling defects develop more slowly (within 60 min) following trauma and hemorrhage [10; 27].…”
Section: Discussionmentioning
confidence: 99%
“…Increased levels of cortisols are further associated with enhanced hepatic gluconeogenesis and a reduced insulinmediated glucose uptake into skeletal muscle and adipose tissue [20,44]. These phenomena may lead to elevated blood glucose levels in association with normal or elevated serum insulin concentrations [53,57]. The blood glucose, Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Blood collected in serum separator tubes for the remaining tests was incubated on ice for 90 min, and centrifuged at 1600 × g (20 min at 4 °C). Insulin levels were measured using the Insulin Enzyme Immunoassay Kit (Cayman Chemical, Cat.#589501, Ann Arbor, MI 48108) according to the manufacturer’s instructions as previously described [ 18 ]. Serum triglyceride and cholesterol levels were measured using an automated chemical analyzer (Vitro 350, OrthoClinical Diagnostics Company, Rochester, NY).…”
Section: Methodsmentioning
confidence: 99%