Insulin resistance during euglycemic clamp studies in chronically undernourished rats with mild streptozocin diabetes

Rao, R. Govinda

doi:10.1016/0026-0495(95)90141-8

Metabolism

1995

DOI: 10.1016/0026-0495(95)90141-8

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Insulin resistance during euglycemic clamp studies in chronically undernourished rats with mild streptozocin diabetes

R. Govinda Rao

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2000

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“…A similar conclusion was reported in rats subjected to food restriction from the fetal stage (11). On the contrary, insulin resistance has also been reported in undernourished rats (22), and it was found to be aggravated in undernourished rats with mild streptozotocin diabetes (22). Moreover, it has been shown that the deleterious effect of chronic malnutrition on ␤-cell function amplifies the overall ␤-cell deficit in mild streptozotocin diabetes, and refeeding reverses this effect (21).…”

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confidence: 72%

Effect of early dietary restriction on insulin action and secretion in the GK rat, a spontaneous model of NIDDM

Álvarez

Bailbé²,

Picarel-Blanchot³

et al. 2000

American Journal of Physiology-Endocrinology and Metabolism

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The availability of the Goto-Kakisaki (GK) rat model of non-insulin-dependent diabetes mellitus prompted us to test the effect of a limited period of undernutrition in previously diabetic young rats on their insulin secretion and insulin action during adult age. Four-week-old female GK rats were either food restricted (35% restriction, 15% protein diet) or protein and energy restricted (35% restriction, 5% protein diet) for 4 wk. Food restriction in the young GK rat lowered weight gain but did not aggravate basal hyperglycemia or glucose intolerance, despite a decrease in basal plasma insulin level. Furthermore, the insulin-mediated glucose uptake by peripheral tissues in the GK rat was clearly improved. We also found that food restriction, when it is coupled to overt protein deficiency in the young GK rat, altered weight gain more severely and slightly decreased basal hyperglycemia but conversely aggravated glucose tolerance. Improvement of basal hyperglycemia was related to repression of basal hepatic glucose hyperproduction, despite profound attenuation of basal plasma insulin level. Deterioration of tolerance to glucose was related to severe blunting of the residual glucose-induced insulin secretion. It is, however, likely that the important enhancement of the insulin-mediated glucose uptake helped to limit the deterioration of glucose tolerance.

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supporting

confidence: 72%

Effect of early dietary restriction on insulin action and secretion in the GK rat, a spontaneous model of NIDDM

Álvarez

Bailbé²,

Picarel-Blanchot³

et al. 2000

American Journal of Physiology-Endocrinology and Metabolism

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Insulin resistance during euglycemic clamp studies in chronically undernourished rats with mild streptozocin diabetes

Cited by 1 publication

References 24 publications

Effect of early dietary restriction on insulin action and secretion in the GK rat, a spontaneous model of NIDDM

Effect of early dietary restriction on insulin action and secretion in the GK rat, a spontaneous model of NIDDM

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