Insulin resistance and sleep-disordered breathing in healthy humans.

Abstract

Fifty healthy, normotensive individuals (34 women) with a mean age of 44.3 +/- 13.2 yr and a mean body mass index of 27.1 +/- 5.4 kg/m2 were tested for the presence or absence of insulin resistance and sleep-disordered breathing. The hypothesis of this investigation was that insulin resistance is associated with sleep-disordered breathing. In vivo insulin action with determination of steady-state plasma glucose (SSPG) and insulin was measured using simultaneous intravenous infusion of somatostatin, glucose, and insulin via a Harvard pump. Determination of sleep-disordered breathing was performed through clinical assessment and portable nocturnal monitoring using a validated sleep apnea recorder. Individuals with > or = 10 hypoxic respiratory events per hour of sleep were significantly more insulin-resistant than subjects without sleep-breathing disorders. After adjusting the relationship between insulin resistance and sleep-disordered breathing for potential confounding variables, it was found that this relationship was entirely dependent on body mass.

Relation of habitual snoring with components of metabolic syndrome in Korean adults

“…In Table 3 Estimated odds ratios of habitual snoring due to the presence vs. the absence of hypertriglyceridemia, low HDL-cholesterol, hypertension, and elevated fasting glucose after adjustment for age, abdominal obesity, and the other metabolic disorders a sleep study on 50 healthy subjects of whom one-third had an apnea-hypopnea index ! 10 with a portable device, no correlation was identified between insulin resistance and sleep-disordered breathing after controlling for body mass index [19]. In another study involving 261 men in which the relative contributions of body weight and sleep apnea to blood pressure, fasting insulin, and fasting glucose were examined, there was an independent association between sleep apnea and fasting insulin levels in those with a body mass index > 29 kg/m 2 [20].…”

“…Previous studies on the relationship between insulin resistance and sleep-disordered breathing have yielded conflicting results, depending upon methodological approaches and target populations [19][20][21]. In Table 3 Estimated odds ratios of habitual snoring due to the presence vs. the absence of hypertriglyceridemia, low HDL-cholesterol, hypertension, and elevated fasting glucose after adjustment for age, abdominal obesity, and the other metabolic disorders a sleep study on 50 healthy subjects of whom one-third had an apnea-hypopnea index !…”

Sleep disturbance as a predictor of type 2 diabetes mellitus in men and women from the general population

“…Habitual snoring and sleep apnoea, both parts of a spectrum of sleep-related breathing disorders, are associated with abnormal fasting glucose and insulin resistance [5,14]. However, there is an emerging body of literature showing that sleep itself, independent of snoring and sleep apnoea, is important in glucose and insulin regulation [9,15].…”

Interações entre síndrome da apnéia obstrutiva do sono e resistência à insulina

“…Stoohs e cols., em 1996, foram os primeiros autores a mostrar que a associação encontrada entre resistência à insulina e apnéia do sono é dependente da massa corporal (17). Entretanto, estudos epidemiológicos recentes afirmaram que a SAOS contribui para a resistência à insulina independentemente do grau e da distribuição da obesidade, idade, sexo, tabagismo e duração do sono (18).…”