Insulin resistance and metabolic parameters in type 2 diabetic patients

Metzler, W; Fischer, Sabine; Köhler, Christof; Pistrosch, Frank; Kindel, B.; Hanefeld, Markolf

doi:10.1016/s0953-6205(01)00202-3

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…Recent studies have demonstrated that leptin can modulate the activators of STAT3, AP-1, extracellular signal regulated kinase-2 (ERK2), and MAPK, all involved in the regulation of proliferation and survival mechanisms, as well as aromatase expression, estrogen synthesis, and ER activation [355, 356]. Furthermore, leptin interferes with insulin signaling, and plasma levels of leptin directly correlate with the degree of insulin resistance in patients with T2D [357], whose association with breast carcinoma has been well studied. Adiponectin, on the other hand, has opposite function to leptin.…”

Section: Obesity Inflammation and Breast Cancermentioning

confidence: 99%

The Role of Chronic Inflammation in Obesity-Associated Cancers

Ramos-Niño

2013

ISRN Oncology

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There is a strong relationship between metabolism and immunity, which can become deleterious under conditions of metabolic stress. Obesity, considered a chronic inflammatory disease, is one example of this link. Chronic inflammation is increasingly being recognized as an etiology in several cancers, particularly those of epithelial origin, and therefore a potential link between obesity and cancer. In this review, the connection between the different factors that can lead to the chronic inflammatory state in the obese individual, as well as their effect in tumorigenesis, is addressed. Furthermore, the association between obesity, inflammation, and esophageal, liver, colon, postmenopausal breast, and endometrial cancers is discussed.

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Section: Obesity Inflammation and Breast Cancermentioning

confidence: 99%