Insulin Resistance and Diabetes Mellitus in Patients with Systemic Lupus
Erythematosus

Munguía‐Realpozo, Pamela; Garcı́a-Carrasco, Mario; Mendoza‐Pinto, Claudia; Etchegaray‐Morales, Ivet; Vélez-Pelcastre, Sandra Karina; Méndez‐Martínez, Socorro; Zamora-Ginez, Irma; Lara, Luis G. Vázquez de; Romero, José Luis Gálvez; Escamilla-Márquez, Marco Antonio

doi:10.2174/1871530322666220908154253

Cited by 7 publications

(6 citation statements)

References 89 publications

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“…The relationship between OAPS and abnormal INSR signaling is rarely reported. However, mounting evidence indicates that increased insulin resistance is more prevalent in other autoimmune diseases compared to controls, for example, in systemic lupus erythematosus (SLE) and rheumatoid arthritis 41 , 42 . Our discoveries from analyzing the circulating EV proteome prompt us to rethink the function of circulating proteins in disease pathogenicity.…”

Section: Discussionmentioning

confidence: 99%

Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions

Tian,

Shi,

Zhang

et al. 2024

Commun Biol

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Proteins in the plasma/serum mirror an individual’s physiology. Circulating extracellular vesicles (EVs) proteins constitute a large portion of the plasma/serum proteome. Thus, deep and unbiased proteomic analysis of circulating plasma/serum extracellular vesicles holds promise for discovering disease biomarkers as well as revealing disease mechanisms. We established a workflow for simple, deep, and reproducible proteome analysis of both serum large and small EVs enriched fractions by ultracentrifugation plus 4D-data-independent acquisition mass spectrometry (4D-DIA-MS). In our cohort study of obstetric antiphospholipid syndrome (OAPS), 4270 and 3328 proteins were identified from large and small EVs enriched fractions respectively. Both of them revealed known or new pathways related to OAPS. Increased levels of von Willebrand factor (VWF) and insulin receptor (INSR) were identified as candidate biomarkers, which shed light on hypercoagulability and abnormal insulin signaling in disease progression. Our workflow will significantly promote our understanding of plasma/serum-based disease mechanisms and generate new biomarkers.

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Section: Discussionmentioning

confidence: 99%

Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions

Tian,

Shi,

Zhang

et al. 2024

Commun Biol

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“…Systemic lupus erythematosus (SLE) is an immune disease. It has been found that IR is more prevalent in SLE patients than in controls ( 61 ), while serum vitamin D is negatively correlated with CD4+/CD8+ T cells ( 62 ), IFN-α levels ( 63 ), IL-17, IL-23 ( 64 ) in SLE patients. 25(OH)D 3 is further converted into 1,25(OH) 2 D 3 in the kidneys by 1α-hydroxylase, which is expressed by antigen-presenting cells ( 65 ), indicating an association of the immune microenvironment with active vitamin D production, suggesting that vitamin D may mediate the disease process in T1DM.…”

Section: Vitamin D and The Pathogenesis Of Diabetesmentioning

confidence: 99%

The impact of vitamin D on the etiopathogenesis and the progression of type 1 and type 2 diabetes in children and adults

Li,

Fu,

et al. 2024

Front. Endocrinol.

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Diabetes is a common chronic metabolic disease with complex causes and pathogenesis. As an immunomodulator, vitamin D has recently become a research hotspot in the occurrence and development of diabetes and its complications. Many studies have shown that vitamin D can reduce the occurrence of diabetes and delay the progression of diabetes complications, and vitamin D can reduce oxidative stress, inhibit iron apoptosis, promote Ca2+ influx, promote insulin secretion, and reduce insulin resistance. Therefore, the prevention and correction of vitamin D deficiency is very necessary for diabetic patients, but further research is needed to confirm what serum levels of vitamin D3 are maintained in the body. This article provides a brief review of the relationship between vitamin D and diabetes, including its acute and chronic complications.

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“…On the other hand, insulin levels and the homeostasis model assessment-estimated insulin resistance (HOMA-IR) index are increased in patients with SLE and SLE with MetS compared to healthy controls [27]. Studies in the literature have shown that SLE patients manifest deficient insulin secretion and a greater risk of IR.…”

Section: Metabolic Dysregulation In Sle and Its Biomarkersmentioning

confidence: 99%

Biomarkers in Systemic Lupus Erythematosus along with Metabolic Syndrome

Corona-Meraz,

Vázquez-Del Mercado,

Sandoval-García

et al. 2024

JCM

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Metabolic syndrome (MetS) is a group of physiological abnormalities characterized by obesity, insulin resistance (IR), and hypertriglyceridemia, which carry the risk of developing cardiovascular disease (CVD) and type 2 diabetes (T2D). Immune and metabolic alterations have been observed in MetS and are associated with autoimmune development. Systemic lupus erythematosus (SLE) is an autoimmune disease caused by a complex interaction of environmental, hormonal, and genetic factors and hyperactivation of immune cells. Patients with SLE have a high prevalence of MetS, in which elevated CVD is observed. Among the efforts of multidisciplinary healthcare teams to make an early diagnosis, a wide variety of factors have been considered and associated with the generation of biomarkers. This review aimed to elucidate some primary biomarkers and propose a set of assessments to improve the projection of the diagnosis and evolution of patients. These biomarkers include metabolic profiles, cytokines, cardiovascular tests, and microRNAs (miRs), which have been observed to be dysregulated in these patients and associated with outcomes.

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Insulin Resistance and Diabetes Mellitus in Patients with Systemic Lupus Erythematosus

Cited by 7 publications

References 89 publications

Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions

Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions

The impact of vitamin D on the etiopathogenesis and the progression of type 1 and type 2 diabetes in children and adults

Biomarkers in Systemic Lupus Erythematosus along with Metabolic Syndrome

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