Insulin resistance, age and depression’s impact on cognition in middle-aged adults from the PREVENT cohort

Bauermeister, Sarah; Yehuda, Michael Ben; Reid, Graham; Howgego, Gregory; Ritchie, Karen; Watermeyer, Tam; Gregory, Sarah; Terrera, Graciela Muñiz; Koychev, Ivan

doi:10.1136/bmjment-2023-300665

Cited by 3 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, in a cross-sectional study of Chinese MDD subjects it was noted, that IR was associated with increased likelihood of suicide attempts [ 15 ]. What is more, a cross-sectional study in middle-aged subjects showed, that higher IR was not only a predictor of higher depressive symptoms but also worse executive functions [ 16 ▪ ].…”

Section: Metabolic Subtype Of Depressionmentioning

confidence: 99%

Consolidating evidence on the role of insulin resistance in major depressive disorder

Krupa,

Dudek,

Siwek

2023

Current Opinion in Psychiatry

View full text Add to dashboard Cite

Purpose of review The circular interactions between type 2 diabetes (TMD2) and major depressive disorder (MDD) are well documented but the understanding of their mechanisms has only recently gained more clarity. Latest research indicates, that the association between TMD2 and MDD is largely mediated by insulin resistance (IR). Recent findings A metabolic subtype of MDD can be distinguished from other MDD subpopulations, that is characterized by predominantly atypical clinical presentation, IR and different responsiveness to antidepressant interventions. IR is a predictor of nonresponse to some antidepressants. The IR seems to be a state-marker of clinical or subclinical depression and the relationship between IR and MDD varies between sexes and ethnicities. Insulin has a direct impact on the monoaminergic systems known to underlie MDD symptoms: serotoninergic and dopaminergic, which are dysregulated in IR subjects. Several trials assessed the efficacy of insulin-sensitizing drugs in MDD with mixed results for metformin and more consistent evidence for pioglitazone and lifestyle intervention/physical activity. Summary Recently published data suggest a significant role of IR in the clinical presentation, pathophysiology and treatment response in MDD. Further research of IR in MDD and integration of existing data into clinical practice are needed.

show abstract

Section: Metabolic Subtype Of Depressionmentioning

confidence: 99%

Consolidating evidence on the role of insulin resistance in major depressive disorder

Krupa,

Dudek,

Siwek

2023

Current Opinion in Psychiatry

View full text Add to dashboard Cite

show abstract

Multimorbidity, lifestyle, and cognitive function: A cross-cultural study on the role of diabetes, cardiovascular disease, cancer, and chronic respiratory diseases

Ma,

Mu,

Jin

et al. 2024

Journal of Affective Disorders

View full text Add to dashboard Cite

The usability and reliability of a smartphone application for monitoring future dementia risk in ageing UK adults

Reid,

Vassilev,

Irving

et al. 2024

Br J Psychiatry

Self Cite

View full text Add to dashboard Cite

Background The rising number of dementia diagnoses and imminent adoption of disease-modifying treatments necessitate innovative approaches to identify individuals at risk, monitor disease course and intervene non-pharmacologically earlier in the disease course. Digital assessments of dementia risk and cognitive function have the potential to outperform traditional in-person assessments in terms of their affordability, accuracy and longitudinal tracking abilities. However, their accessibility and reliability in older adults is unclear. Aims To evaluate the usability and reliability of a smartphone assessment of lifestyle and cognitive factors relevant to dementia risk in a group of UK-based older adults. Method Cognitively healthy adults (n = 756) recruited through the Dementias Platform UK Great Minds volunteer register completed three assessments of cognitive function and dementia risk over a 3-month period and provided usability feedback on the Five Lives smartphone application (app). We evaluated cognitive test scores for age, gender and higher education effects, normality distributions, test–retest reliability and their relationship with participants’ lifestyle dementia risk factors. Results Participants found the app ‘easy to use’, ‘quick to complete’ and ‘enjoyable’. The cognitive tests showed normal or near-to-normal distributions, variable test–retest reliabilities and age-related effects. Only tests of verbal ability showed gender and education effects. The cognitive tests did not correlate with lifestyle dementia risk scores. Conclusions The Five Lives assessment demonstrates high usability and reliability among older adults. These findings highlight the potential of digital assessments in dementia research and clinical practice, enabling improved accessibility and better monitoring of cognitive health on a larger scale than traditional in-person assessments.

show abstract

Insulin resistance, age and depression’s impact on cognition in middle-aged adults from the PREVENT cohort

Cited by 3 publications

References 32 publications

Consolidating evidence on the role of insulin resistance in major depressive disorder

Consolidating evidence on the role of insulin resistance in major depressive disorder

Multimorbidity, lifestyle, and cognitive function: A cross-cultural study on the role of diabetes, cardiovascular disease, cancer, and chronic respiratory diseases

The usability and reliability of a smartphone application for monitoring future dementia risk in ageing UK adults

Contact Info

Product

Resources

About