Insulin regulation of muscle glucose metabolism: Role of pre‐receptorial mechanisms

Capaldo, Brunella; Saccà, Luigi

doi:10.1002/dmr.5610110405

Cited by 1 publication

(1 citation statement)

References 114 publications

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“…Changes in blood flow at this time could reflect a changing balance between splanchnic and peripheral blood flow during glucose absorption. In the present study, insulin levels at peak blood flow are comparable to those associated with vasodilatation during systemic insulin infusion (Ϸ600 pmol/L) (Capaldo and Saccà 26 ). In addition, changes in forearm blood flow correlated with those in insulin levels in normotensive subjects.…”

Section: Endogenous Insulin and Forearm Vasodilatationsupporting

confidence: 80%

Effects of Mild Exercise on Insulin Sensitivity in Hypertensive Subjects

et al. 2002

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Abstract-Physical exercise increases insulin sensitivity in conditions associated with insulin resistance, such as obesity and diabetes, but little is known in this regard in hypertension. Whether postexercise changes in hemodynamics and/or changes in insulin-induced vasodilatation could contribute to a postexercise increase in insulin sensitivity in hypertensive subjects is unknown. We investigated the effects of acute physical exercise on insulin sensitivity in 10 hypertensive and 10 normotensive subjects during a control evaluation (CTRL), during lower body negative pressure (LBNP), after 30 minutes of mild bicycle exercise (POSTEX), and during LBNP after exercise (POSTEXϩLBNP). Insulin-induced vasodilatation was assessed from peak forearm blood flow during the intravenous glucose tolerance test. Cardiac output (4.9Ϯ0.3 versus 5.3Ϯ0.4 L/min, meanϮSEM) and insulin sensitivity (the glucose disappearance rate over insulin area under the curve: 0.91Ϯ0.07 versus 1.38Ϯ0.25 min Ϫ1 /[pmol · L Ϫ1 ] · minute) were lower (both PϽ0.05) in hypertensive than in normotensive subjects, respectively. Cardiac output decreased during LBNP, increased during POSTEX, and was similar to control during POSTEXϩLBNP in both groups. Insulin sensitivity was unchanged during LBNP, increased during POSTEX, and remained elevated during POSTEXϩLBNP in hypertensive subjects, whereas it remained unchanged in normotensives. Peak forearm blood flow was significantly lower in hypertensive than in normotensive subjects, despite higher insulin levels in hypertensives, and was not modified by LBNP or exercise. In conclusion, insulin sensitivity increases after exercise in hypertensive subjects, and the increase in cardiac output does not contribute to this effect. Endogenous insulin-induced vasodilatation is reduced in hypertensive subjects, and this insulin action is not affected by physical exercise.

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Section: Endogenous Insulin and Forearm Vasodilatationsupporting

confidence: 80%