Insulin receptors in the kidneys in health and disease

Abstract

The population of patients with end stage renal disease (ESRD) is increasing, lengthening waiting lists for kidney transplantation. Majority of the patients are not able to receive a kidney transplant in timely manner even though it is well established that patient survival and quality of life after kidney transplantation is far better when compared to being on dialysis. A large number of patients who desire a kidney transplant ultimately end up needing some form of dialysis therapy. Most of incident ESRD patients choose hemodialysis (HD) over peritoneal dialysis (PD) as the modality of choice in the United States, even though studies have favored PD as a better choice of pre-transplant dialysis modality than HD. PD is largely underutilized in the United States due to variety of reasons. As a part of the decision making process, patients are often educated how the choice regarding modality of dialysis would fit into their life but it is not clear and not usually discussed, how it can affect eventual kidney transplantation in the future. In this article we would like to discuss ESRD demographics and outcomes, modality of dialysis and kidney transplant related events. We have summarized the data comparing PD and HD as the modality of dialysis and its impact on allograft and recipient outcomes after kidney transplantation.

The Interaction of the Endogenous Hydrogen Sulfide and Oxytocin Systems in Fluid Regulation and the Cardiovascular System

“…Interestingly, insulin receptors also act via the PI3K/Akt signaling pathway [ 93 ], and both OT and H 2 S are involved in the modulation of energy homeostasis and glucose metabolism (reviewed recently for OT [ 94 ] and H 2 S [ 95 ]). OT, CSE and CBS are expressed in insulin-sensitive tissues [ 95 , 96 ].…”

mHealth intervention and health-related quality of life for haemodialysis patients in selected counties of Kenya

“…Patients ESRD require regular maintenance dialysis or kidney transplant for the patient to survive. 3 according to, ESRD is one of the major causes of mortality, and impaired qol. 4 Ranked 12 th most dominant cause of death globally, CKD is associated with over 1.1 million deaths annually hence presenting a major public health challenge.…”

Evaluation of kidney recipients and donors for transplantation

“…56, No. 4, p. 381-396 UVOD Presađivanje bubrega prva je metoda nadomjesnog liječenja pacijenata sa završnim stupnjem kronične bubrežne bolesti (ZSKBB) 1 . Kod svakog potencijalnog primatelja treba prije odluke o liječenju presađivanjem bubrega usporediti njezine rizike s rizicima kojima je pacijent izložen ako nastavi liječenje dijalitičkim metodama.…”