Insulin Modulates Neural Activity of Pyramidal Neurons in the Anterior Piriform Cortex

Zhou, Yang; Wang, Xiaojie; Cao, Tiantian; Xu, Jinshan; Wang, Dejuan; Restrepo, Diego; Li, Anan

doi:10.3389/fncel.2017.00378

Cited by 20 publications

(38 citation statements)

References 63 publications

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“…28 activity indicate that leptin may affect the representation transferred from the OB to higher brain centers for further odor discrimination and cognition. Although the mechanism by which insulin affects the activity of piriform cortex has been revealed in recent studies, 15,52 it will be interesting to investigate how leptin modulates neural activity in piriform cortex in future studies. 42,49 The odor-evoked beta oscillation, which is thought to reflect the interaction between the OB and piriform cortex, 50,51 was decreased after administration of leptin, indicating that the communication between the OB and piriform cortex may be disrupted by leptin.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it is likely that the decreased odor response of the mitral cells and the weaker communication between the OB and piriform cortex will alter neural activity in piriform cortex, impairing odor discrimination performance during the go/no-go task. Although the mechanism by which insulin affects the activity of piriform cortex has been revealed in recent studies, 15,52 it will be interesting to investigate how leptin modulates neural activity in piriform cortex in future studies.…”

Section: Discussionmentioning

confidence: 99%

“…15 Briefly, a laser beam from a 488 nm laser (OBIS 488LS; Coherent) was reflected by a dichroic mirror (MD498; Thorlabs), focused through an objective lens (10×, NA = 0.3; Olympus) and then coupled to an optical commutator (Doric Lenses). 15 Briefly, a laser beam from a 488 nm laser (OBIS 488LS; Coherent) was reflected by a dichroic mirror (MD498; Thorlabs), focused through an objective lens (10×, NA = 0.3; Olympus) and then coupled to an optical commutator (Doric Lenses).…”

Section: Fiber Photometrymentioning

confidence: 99%

“…30 Thus, we next compared the LFP signals in awake, head-fixed mice before and after injection of leptin. As in previous studies, 15,30 the raw LFP signals were divided into different frequency bands: theta, 2-12 Hz; beta, 15-35 Hz; low gamma, 36-65 Hz; and high gamma, 66-95 Hz (Figure 4). Leptin had no significant effect on any frequency band of the ongoing LFP ( Figure 4B, Two-way repeated measures ANOVA, F (1,90) = 0.46 and P = 0.51, F (1,190) = 0.05 and P = 0.83, F (1,290) = 1.24 and P = 0.29, F (1,290) = 1.61 and P = 0.23 for the theta, beta, lowgamma, and high-gamma bands, respectively).…”

Section: Leptin Alters the Odor-evoked Changes In Beta And Gamma Osmentioning

confidence: 99%

“…[10][11][12] Receptors for these peptide hormones are also widely distributed in the olfactory system, including the olfactory epithelium, olfactory bulb (OB), and piriform cortex. [13][14][15][16] Thus, these peptide hormones may significantly modulate olfaction by activating their receptors in the olfactory system. 1 Leptin is an important signal through which the hypothalamus senses the nutritional state and modulates food intake and the energy balance.…”

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Leptin modulates olfactory discrimination and neural activity in the olfactory bulb

Sun

Ke-ke

et al. 2019

Acta Physiologica

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Aim Leptin is an important peptide hormone that regulates food intake and plays a crucial role in modulating olfactory function. Although a few previous studies have investigated the effect of leptin on odor perception and discrimination in rodents, research on the neural basis underlying the behavioral changes is lacking. Here we study how leptin affects behavioral performance during a go/no‐go task and how it modulates neural activity of mitral/tufted cells in the olfactory bulb, which plays an important role in odor information processing and representation. Methods A go/no‐go odor discrimination task was used in the behavioral test. For in vivo studies, single unit recordings, local field potential recordings and fiber photometry recordings were used. For in vitro studies, we performed patch clamp recordings in the slice of the olfactory bulb. Results Behaviorally, leptin affects performance and reaction time in a difficult odor‐discrimination task. Leptin decreases the spontaneous firing of single mitral/tufted cells, decreases the odor‐evoked beta and high gamma local field potential response, and has bidirectional effects on the odor‐evoked responses of single mitral/tufted cells. Leptin also inhibits the population calcium activity in genetically identified mitral/tufted cells and granule cells. Furthermore, in vitro slice recordings reveal that leptin inhibits mitral cell activity through direct modulation of the voltage‐sensitive potassium channel. Conclusions The behavioral reduction in odor discrimination observed after leptin administration is likely due to decreased neural activity in mitral/tufted cells, caused by modulation of potassium channels in these cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Fiber Photometrymentioning

confidence: 99%

Section: Leptin Alters the Odor-evoked Changes In Beta And Gamma Osmentioning

confidence: 99%

mentioning

confidence: 99%

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Leptin modulates olfactory discrimination and neural activity in the olfactory bulb

Sun

Ke-ke

et al. 2019

Acta Physiologica

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Modulation of olfactory-driven behavior by metabolic signals: role of the piriform cortex

et al. 2018

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Olfaction is one of the major sensory modalities that regulates food consumption and is in turn regulated by the feeding state. Given that the olfactory bulb has been shown to be a metabolic sensor, we explored whether the anterior piriform cortex (aPCtx)-a higher olfactory cortical processing area-had the same capacity. Using immunocytochemical approaches, we report the localization of Kv1.3 channel, glucose transporter type 4, and the insulin receptor in the lateral olfactory tract and Layers II and III of the aPCtx. In current-clamped superficial pyramidal (SP) cells, we report the presence of two populations of SP cells: glucose responsive and non-glucose responsive. Using varied glucose concentrations and a glycolysis inhibitor, we found that insulin modulation of the instantaneous and spike firing frequency are both glucose dependent and require glucose metabolism. Using a plethysmograph to record sniffing frequency, rats microinjected with insulin failed to discriminate ratiometric enantiomers; considered a difficult task. Microinjection of glucose prevented discrimination of odorants of different chain-lengths, whereas injection of margatoxin increased the rate of habituation to repeated odor stimulation and enhanced discrimination. These data suggest that metabolic signaling pathways that are present in the aPCtx are capable of neuronal modulation and changing complex olfactory behaviors in higher olfactory centers.

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Dopamine D1 Receptor in the Nucleus Accumbens Modulates the Emergence from Propofol Anesthesia in Rat

et al. 2021

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Insulin Modulates Neural Activity of Pyramidal Neurons in the Anterior Piriform Cortex

Cited by 20 publications

References 63 publications

Leptin modulates olfactory discrimination and neural activity in the olfactory bulb

Leptin modulates olfactory discrimination and neural activity in the olfactory bulb

Modulation of olfactory-driven behavior by metabolic signals: role of the piriform cortex

Dopamine D1 Receptor in the Nucleus Accumbens Modulates the Emergence from Propofol Anesthesia in Rat

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