Insulin-mimetic vanadyl—dithiocarbamate complexes

Watanabe, Hiromi; Tamura, Hiro Omi; Yasui, Hiroyuki; Matsushita, Rokuji; Takada, Jitsuya

doi:10.1016/s0020-1693(98)00309-0

Cited by 63 publications

(26 citation statements)

References 51 publications

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“…[31] More generally, metal complexes of thiosemicarbazones have also been discussed in the context of their antibacterial and antifungal properties. [32,33] …”

Section: Introductionmentioning

confidence: 99%

Vanadium(IV and V) Complexes ContainingSNO (Dithiocarbonylhydrazone; Thiosemicarbazone) Donor Sets

Wang

Ebel

Schulzke

et al. 2001

Eur. J. Inorg. Chem.

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“…[31] More generally, metal complexes of thiosemicarbazones have also been discussed in the context of their antibacterial and antifungal properties. [32,33] …”

Section: Introductionmentioning

confidence: 99%

Vanadium(IV and V) Complexes ContainingSNO (Dithiocarbonylhydrazone; Thiosemicarbazone) Donor Sets

Wang

Ebel

Schulzke

et al. 2001

Eur. J. Inorg. Chem.

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“…Encouraged with the results, we have proposed the vanadyl-dithiocarbamate complexes with VO(S 4 ) coordination mode as orally active complexes [30,31].…”

Section: Orally Active and Long-term Acting Vanadyl Complexesmentioning

confidence: 67%

Role of vanadium in treating diabetes

Sakurai

Fujisawa

Fujimoto

et al. 1999

J. Trace Elem. Exp. Med.

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Since insulin-dependent diabetes mellitus (IDDM), which causes many severe secondary complications, is characterized by hyperglyceria due to absolute deficiency of insulin, the diseases is controlled by daily injection of insulin. Therefore, the development of insulin replacements of mimetics upon oral administration is an important investigation. Recent studies indicate that vanadium, which is proposed to be one of essential trace elements in animals and humans, relates to both glucose and lipid metabolisms, and the metal in turn shows insulin-mimetic effect. Thus several types of vanadium complex have been proposed to be insulin mimetics. In 1990, we proposed first vanadyl-cysteinate complex, which normalized the blood glucose level of IDDM rats on oral administration. On the other hand, simple vanadium compounds such as vanadyl sulfate and sodium vanadate have been reported to be useful to treat human non-insulin-dependent diabetes mellitus (NIDDM). Based on the observations, we have developed several types of vanadyl complexes with different coordination modes such as VO(0 4 ), VO(N 4 ), VO(S 4 ), VO(O 2 N 2 ), VO(S 2 N 2 ) and VO(O 2 S 2 ), and found that vanadyl-methylpicolinate complex with long acting character and low toxicity is the most effective to treat IDDM as well as NIDDM rats, when administered orally. The mechanism was also studied with respect to the pharmacokinetic analysis and vanadium distribution in animals.

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“…The results demonstrated that VO-g-PGA cannot lower blood glucose of nondiabetic rats, which was consistent with previous report. 20 This may caused by the poor glucose-lowering effect of vanadium compared with insulin. Furthermore the blood glucose levels of nondiabetic rats are relatively low, which is very hard to be lowered.…”

Section: Discussionmentioning

confidence: 99%

Effects of Insulin-Mimetic Vanadyl-Poly(γ-Glutamic Acid) Complex on Diabetic Rat Model

Liu

et al. 2010

Journal of Pharmaceutical Sciences

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Insulin-mimetic vanadyl—dithiocarbamate complexes

Cited by 63 publications

References 51 publications

Vanadium(IV and V) Complexes ContainingSNO (Dithiocarbonylhydrazone; Thiosemicarbazone) Donor Sets

Vanadium(IV and V) Complexes ContainingSNO (Dithiocarbonylhydrazone; Thiosemicarbazone) Donor Sets

Role of vanadium in treating diabetes

Effects of Insulin-Mimetic Vanadyl-Poly(γ-Glutamic Acid) Complex on Diabetic Rat Model

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