Insulin-Loaded Poly(ε-Caprolactone) Nanoparticles: Efficient, Sustained and Safe Insulin Delivery System

Araújo, Thiago Matos de; Teixeira, Zaine; Barbosa-Sampaio, Helena Cristina; Rezende, Luiz F.; Boschero, Antônio Carlos; Durán, Nélson; Höehr, Nelci Fenalt

doi:10.1166/jbn.2013.1607

Cited by 19 publications

(9 citation statements)

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“…Ossa and co-workers (2012) (22) developed PCL NP containing cannabinoid using the single emulsion method and obtained 58.68% yield, which was quite similar to the results showed in this study. Similar results of protein loading efficiency (90.6%) were also observed by De Araújo and co-workers during the development of insulin loaded PCL nanoparticles by doubleemulsion technique (23).…”

Section: Resultssupporting

confidence: 87%

Development and Characterization of Nisin Nanoparticles as Potential Alternative for the Recurrent Vaginal Candidiasis Treatment

et al. 2016

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Abstract. The aim of this work was the development and characterization of nisin-loaded nanoparticles and the evaluation of its potential antifungal activity. Candidiasis is a fungal infection caused by Candida sp. considered as one of the major public health problem currently. The discovery of antifungal agents that present a reduced or null resistance of Candida sp. and the development of more efficient drug release mechanisms are necessary for the improvement of candidiasis treatment. Nisin, a bacteriocin commercially available for more than 50 years, exhibits antibacterial action in food products with potential antifungal activity. Among several alternatives used to modulate antifungal activity of bacteriocins, polymeric nanoparticles have received great attention due to an effective drug release control and reduction of therapeutic dose, besides the minimization of adverse effects by the preferential accumulation in specific tissues. The nisin nanoparticles were prepared by double emulsification and solvent evaporation methods. Nanoparticles were characterized by dynamic light scattering, zeta potential, Fourier transform infrared, X-ray diffraction, differential scanning calorimetry, and scanning electron microscopy. Antifungal activity was accessed by pour plate method and cell counting using Candida albicans strains. The in vitro release profile and in vitro permeation studies were performed using dialysis bag method and pig vaginal mucosa in Franz diffusion cell, respectively. The results revealed nisin nanoparticles (300 nm) with spherical shape and high loading efficiency (93.88 ± 3.26%). In vitro test results suggest a promising application of these nanosystems as a prophylactic agent in recurrent vulvovaginal candidiasis and other gynecological diseases.

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Section: Resultssupporting

confidence: 87%

Development and Characterization of Nisin Nanoparticles as Potential Alternative for the Recurrent Vaginal Candidiasis Treatment

et al. 2016

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“…However, as described in [87], the conventional techniques such as solvent evaporation, coacervation and spray-drying methods, can be harmful to the substance being encapsulated. Thus, the use of biopolymers as hydrophilic emulsifiers in W/O/W double emulsions often allows to achieve more stable emulsions [64,[88][89][90].…”

Section: Encapsulation Of Active Ingredients By Double W/o/w Emulsionsmentioning

confidence: 99%

The Use of Polymer and Surfactants for the Microencapsulation and Emulsion Stabilization

Sharipova¹,

Aidarova²,

Mutaliyeva³

et al. 2017

Colloids and Interfaces

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Polymer/surfactant mixtures have a wide range of industrial and technological applications, one of them being the use in microencapsulation and emulsion stabilization processes. These mixtures are able to form adsorption layers at the surface of oil droplets and so affect the emulsion stability, which depends on the polyelectrolyte/surfactant nature, concentrations ratio, method of the emulsification, etc. Polyelectrolytes alone show low surface activity in contrast to surfactants, which adsorb at the water/oil interface, making the droplets charged, but they are insufficient to stabilize emulsions. When an oppositely-charged polymer is added to the surfactant solution, a steric barrier is formed, which prevents coalescence and enhances the stability. The present review is devoted to the recent studies of the use of polymer/surfactant mixtures for the encapsulation of active ingredients and stabilization of single and double emulsions. Active ingredients are added to the oil phase prior to emulsification so that any subsequent dissolution of the core, like in other encapsulation protocols, can be omitted. By measuring the interfacial tension and dilational rheology it is possible to find optimum conditions for the emulsion formation and hence for encapsulation. Therefore, such systems have become a prominent approach for the encapsulation of active ingredients.

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“…Studies carried out at the State University of Campinas, Brazil, using insulin-loaded PCL NPs demonstrated that PCL NPs were biocompatible and had an insulin encapsulation efficiency of 90.6%. Animal studies demonstrated that the nanoparticle formulation maintained low BGLs, proving a controlled release system [32]. Researchers in France investigated the ability of PCL-blended polycationic acrylic NPs for oral insulin administration.…”

Section: Polymeric Nanomaterials: Properties and Applications In Imentioning

confidence: 99%

Polymer-Based Nanoparticle Strategies for Insulin Delivery

et al. 2019

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Diabetes mellitus (DM) is a chronic metabolic illness estimated to have affected 451 million individuals to date, with this number expected to significantly rise in the coming years. There are two main classes of this disease, namely type 1 diabetes (T1D) and type 2 diabetes (T2D). Insulin therapy is pivotal in the management of diabetes, with diabetic individuals taking multiple daily insulin injections. However, the mode of administration has numerous drawbacks, resulting in poor patient compliance. In order to optimize insulin therapy, novel drug delivery systems (DDSes) have been suggested, and alternative routes of administration have been investigated. A novel aspect in the field of drug delivery was brought about by the coalescence of polymeric science and nanotechnology. In addition to polymeric nanoparticles (PNPs), insulin DDSes can incorporate the use of nanoplatforms/carriers. A combination of these systems can bring about novel formulations and lead to significant improvements in the drug delivery system (DDS) with regard to therapeutic efficacy, bioavailability, increased half-life, improved transport through physical and chemical barriers, and controlled drug delivery. This review will discuss how recent developments in polymer chemistry and nanotechnology have been employed in a multitude of platforms as well as in administration routes for the safe and efficient delivery of insulin for the treatment of DM.

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Insulin-Loaded Poly(ε-Caprolactone) Nanoparticles: Efficient, Sustained and Safe Insulin Delivery System

Cited by 19 publications

References 0 publications

Development and Characterization of Nisin Nanoparticles as Potential Alternative for the Recurrent Vaginal Candidiasis Treatment

Development and Characterization of Nisin Nanoparticles as Potential Alternative for the Recurrent Vaginal Candidiasis Treatment

The Use of Polymer and Surfactants for the Microencapsulation and Emulsion Stabilization

Polymer-Based Nanoparticle Strategies for Insulin Delivery

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