Insulin-like growth factor II (IGF-II) and follicle stimulating hormone (FSH) combinations can improve the in vitro development of grown oocytes enclosed in caprine preantral follicles

Duarte, A.B.G.; Araújo, Valdevane Rocha; Chaves, Roberta Nogueira; Silva, Gerlane Modesto da; Luz, Valesca Barreto; Haag, K.T.; Magalhães-Padilha, D.M.; Almeida, A. P.; Lobo, Carlos Henrique; Campello, C.C.; Figueiredo, J.R.

doi:10.1016/j.ghir.2012.12.002

Cited by 18 publications

(11 citation statements)

References 34 publications

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“…Various in vitro systems have been employed for the culture of preantral follicles in various mammalian species, such as cattle [85], goats [86], non-human primates [66], and humans [87]. However, the production of healthy offspring from oocytes of preantral follicles matured in vitro has been reported only in mice thus far [88].…”

Section: Role Of Androgens In Early Follicular Developmentmentioning

confidence: 99%

The Role of Androgen Hormones in Early Follicular Development

Gervásio

Bernuci

Sá

et al. 2014

ISRN Obstetrics and Gynecology

104

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Background. Although chronic hyperandrogenism, a typical feature of polycystic ovary syndrome, is often associated with disturbed reproductive performance, androgens have been shown to promote ovarian follicle growth in shorter exposures. Here, we review the main effects of androgens on the regulation of early folliculogenesis and the potential of their application in improving follicular in vitro growth. Review. Androgens may affect folliculogenesis directly via androgen receptors (ARs) or indirectly through aromatization to estrogen. ARs are highly expressed in the granulosa and theca cells of early stage follicles and slightly expressed in mature follicles. Short-term androgen exposure augments FSH receptor expression in the granulosa cells of developing follicles and enhances the FSH-induced cAMP formation necessary for the transcription of genes involved in the control of follicular cell proliferation and differentiation. AR activation also increases insulin-like growth factor (IGF-1) and its receptor gene expression in the granulosa and theca cells of growing follicles and in the oocytes of primordial follicles, thus facilitating IGF-1 actions in both follicular recruitment and subsequent development. Conclusion. During the early and intermediate stages of follicular maturation, locally produced androgens facilitate the transition of follicles from the dormant to the growing pool as well as their further development.

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Section: Role Of Androgens In Early Follicular Developmentmentioning

confidence: 99%

The Role of Androgen Hormones in Early Follicular Development

Gervásio

Bernuci

Sá

et al. 2014

ISRN Obstetrics and Gynecology

104

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“…Similarly, IGF-I also had no effect on extrusion of oocytes when supplemented individually; but it showed positive effect in combination with T 4 + FSH (0% vs. 18.3%). IGF-I in the presence of FSH, maintained the growth and survival of adult goat PFs (50-150 ) (Huanmin and Yong, 2000;Silva et al, 2009;Duarte et al, 2013). This could be related to the positive effect of IGF-I on FSH induced steroid production and stimulated cell growth (Erickson and Shimasaki, 2001).…”

Section: Discussionmentioning

confidence: 85%

In vitro culture of goat preantral follicles from fetal ovaries

Amin¹,

Reddy²,

Rao³

et al. 2013

Small Ruminant Research

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“…Isolated secondary follicles (~200 µm) improved their growth rates in the presence of increasing concentrations of FSH (100 ng/ml D0-D6; 500 ng/ml D6-D12; 1000 ng/ml D12-D18) alone (Saraiva et al, 2011) or in combination with LH and/or EGF (Saraiva et al, 2010;Silva et al, 2013). Moreover, sequential increasing FSH concentrations stimulated oocyte meiotic resumption to the GVBD stage when added alone (Saraiva et al, 2011) or in combination with IGF-I (Magalhães-Padilha et al, 2012b), while a low number of oocytes were able to reach the MII stage when sequential FSH was combined with: insulin (Chaves et al, 2012), IGF-II (Duarte et al, 2013), EGF (Silva et al, 2013), LH and EGF (Saraiva et al, 2010), GH (Magalhães et al, 2011), and VEGF (Araújo et al, 2011;Silva et al, 2014). Moreover, a few of these MII oocytes were fertilized and continued further development into 8-cell embryo (Silva et al, 2014), 16-cell embryo (Saraiva et al, 2010), and morula (Magalhães et al, 2011), which is the latest embryo developmental stage attained so far.…”

Section: Caprinementioning

confidence: 99%

Advances in in vitro folliculogenesis in domestic ruminants

Figueiredo¹,

Lima²,

Santos³

2019

Anim Reprod

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The in vitro follicle culture (IVFC) represents an outstanding tool to enhance our understanding of the control of folliculogenesis and to allow the future use of a large number of immature oocytes enclosed in preantral follicles (PFs) in assisted reproductive techniques in humans as well as in others mammalian species including the ruminants. So far, the best results of IVFC were reported from mice with the production of live offspring from primordial follicles cultured in vitro. Live birth has been obtained after the in vitro culture of bovine early antral follicles. However, in other ruminant species, these results have been limited to the production of a variable number of mature oocytes and low percentages of embryos after in vitro culture of goat, buffalo and sheep isolated secondary preantral follicles. The present review presents and discusses the main findings, limitations, and prospects of in vitro folliculogenesis in ruminants focusing on bovine, caprine, and ovine species.

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Insulin-like growth factor II (IGF-II) and follicle stimulating hormone (FSH) combinations can improve the in vitro development of grown oocytes enclosed in caprine preantral follicles

Cited by 18 publications

References 34 publications

The Role of Androgen Hormones in Early Follicular Development

The Role of Androgen Hormones in Early Follicular Development

In vitro culture of goat preantral follicles from fetal ovaries

Advances in in vitro folliculogenesis in domestic ruminants

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