Insulin-like growth factor II (IGF-II) mRNA expression during skeletal muscle development of double-muscled and normal bovine foetuses

Listrat, Anne; Belair, Lucette; Picard, Brigitte; Boulle, Nathalie; Geay, Y.; Djiane, Jean; Jammes, Hélène

doi:10.1051/rnd:19990144

Cited by 8 publications

(10 citation statements)

References 19 publications

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“…Kocamis et al [21] showed that IGF-II mRNA levels were significantly higher in myostatin knockout mice soleus muscles with no translation in active myostatin than in those of control mice. We can thus hypothesise, that our previous results (more IGF-II mRNA in double-muscled animals where myostatin is inactive) [8] were in agreement with those of Kocamis et al (21) (more IGF-II mRNA in animals where there is no myostatin). It would have been interesting to discuss possible relations between IGF-II and GHR, but to our knowledge, no relation has been found in the literature between GHR mRNA abundance and the IGF-II mRNA level [33].…”

Section: Discussionsupporting

confidence: 93%

“…Indeed, these growth factors are known to play a role in muscle differentiation [7]. In addition, in a previous study, we showed that IGF-II mRNA were present in large amounts in foetal muscle cells [8].…”

Section: Introductionmentioning

confidence: 67%

“…One of the objectives of the present study was to investigate the ontogeny of GHR mRNA and to compare it to that of IGF-II [8] and myostatin [22] mRNA previously described in the same samples in our laboratory. In addition, in order to better understand the regulation of the differentiation of muscle fibres, we chose an hypertrophied muscle in double-muscled animals, the semitendinosus (ST) muscle.…”

Section: Introductionmentioning

confidence: 99%

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Growth hormone receptor gene expression in the skeletal muscle of normal and double-muscled bovines during foetal development

Listrat

Hocquette²,

Picard³

et al. 2005

Reprod. Nutr. Dev.

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-The expression of the growth hormone receptor (GHR) gene was investigated in semitendinosus muscle during bovine foetal development in both normal and double-muscled Charolais foetuses which differ with respect to muscle development. Northern-blot analysis of foetal muscle RNA preparations with a GHR cDNA probe identified the 4.5 kb GHR mRNA as early as 130 days post-conception. In double-muscled animals, the expression of GHR mRNA increased from 130 to 210 days of gestation while it stayed stable in normal ones. It was significantly higher (P < 0.05) in double-muscled foetuses compared to normal ones from the second third of gestation. Northern-blot analysis of foetal muscle RNA preparations from both genotypes with a β-actin cDNA probe, revealed lower β-actin gene expression in double-muscled foetuses than in normal ones, suggesting a delay in the differentiation of muscle cells. In situ hybridisation revealed the localisation of specific GHR mRNA in muscle cells at all gestation stages analysed (130, 170, 210 days postconception) but not in connective tissue surrounding the muscle cells. At the adult stage, the hybridisation signal was also very high and observed in muscle cells only. These results show the ontogeny of GHR mRNA in bovine muscle and demonstrate a difference between normal and doublemuscled animals. muscle / bovine / receptor / growth hormone / in situ hybridisation

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

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Growth hormone receptor gene expression in the skeletal muscle of normal and double-muscled bovines during foetal development

Listrat

Hocquette²,

Picard³

et al. 2005

Reprod. Nutr. Dev.

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“…In cattle, the IGF-I, IGF-II and insulin receptor concentrations were shown to decrease throughout foetal development from 3 to 5 months of age onwards in both the skeletal muscle (Boge et al, 1995;Listrat et al, 1999b) and the heart (Hocquette et al, 2006 for IGF-I and insulin receptors only). In various mammals, increase in IGF-I (Jensen et al, 2003 for humans) and IGF-II plasma levels (Listrat et al, 1999a for cattle) were observed throughout gestation. Therefore, the IGF-I, IGF-II and insulin receptor levels are the lowest at the end of gestation when the IGF-I levels in foetuses are the highest, when foetal glucose level is the lowest and when foetal GLUT4 expression increases (Hocquette et al, 2006).…”

Section: Endocrine and Metabolic Regulation Of Muscle Physiology Befomentioning

confidence: 99%

Endocrine and metabolic regulation of muscle growth and body composition in cattle

Hocquette

2010

Animal

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Muscle metabolism (in interaction with other organs and tissues, including adipose tissue) plays an important role in the control of growth and body composition. Muscle ontogenesis has been described in different genotypes of cattle for myofibres, connective tissue and intramuscular depots. The ontogenesis or the action of putatively important factors controlling muscle development (IGF-II expression, IGF receptors, growth hormone (GH) receptor, myostatin, basic fibroblast growth factor, transforming growth factor-b1, insulin and thyroid hormones) has also been studied on bovine foetal muscle samples and satellite cells. The glucose/ insulin axis has been specifically studied in both the bovine adipose tissue and heart. Clearly, cattle, like sheep, are mature species at birth based on their muscle characteristics compared to other mammalian or farm animal species. The different myoblast generations have been well characterised in cattle, including the second generation which is liable to be affected by foetal undernutrition at least in sheep. Interesting genotypes, for example, double-muscled genotype, have been characterised by an altered metabolic and endocrine status associated with a reduced fat mass, specific muscle traits and different foetal characteristics. Finally, the recent development of genomics in cattle has allowed the identification of novel genes controlling muscle development during foetal and postnatal life. Generally, a high muscle growth potential is associated with a reduced fat mass and a switch of muscle fibres towards the glycolytic type. The possibility and the practical consequences of manipulating muscle growth and, hence, body composition by nutritional and hormonal factors are discussed for bovines based on our current biological knowledge.

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“…Assuming a similar trend for the hormonal status in humans and cattle i.e. an increase in IGF-I levels throughout gestation [4] and taking into account the increase in IGF-II plasma levels with increasing age in foetal cattle [53], IGF-I, IGF-II and insulin receptor levels would be low at those stages where IGF-I and placental GH levels in pregnant females and IGF-I levels in foetuses are the highest [4], when foetal glucose level is the lowest and when foetal GLUT4 expression increases (present study). Furthermore, other in vitro studies with cultured cells from the rat hindlimb during differentiation have shown that GLUT1 is abundant in myoblasts, whereas GLUT4 is expressed in spontaneously contracting myotubes but absent in myoblasts [10].…”

Section: Overall Differentiation Of the Heart And Adipose Tissuementioning

confidence: 99%

Prenatal developmental changes in glucose transporters, intermediary metabolism and hormonal receptors related to the IGF/insulin-glucose axis in the heart and adipose tissue of bovines

et al. 2006

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-Glucose transporter ontogenesis is likely to play a key role in glucose uptake by foetal tissues in order to satisfy their energy requirements. We thus investigated developmental changes in the bovine heart and perirenal adipose tissue in two glucose transporter isoforms, namely GLUT1 and GLUT4, the latter being responsible for the regulation of glucose uptake by insulin. Other key players of the glucose/insulin axis were also assessed. Plasma glucose concentration in the foetus was lower at 8 and 8.5 months of age than previously. In the heart, GLUT1 protein level markedly decreased between 3 and 4 months of age, whereas the number of insulin and IGF-I binding sites continually decreased, especially between 7 and 8 or 8.5 months of age. On the contrary, the GLUT4 level increased until 8 months of age and remained high until 2 weeks after birth. The activities of enzymes of glucose metabolism (namely phosphofructokinase [PFK] and lactate dehydrogenase [LDH]) increased throughout gestation and reached a plateau at 6 and 8.5 months of age for PFK and LDH, respectively. The activities of enzymes involved in fatty acid metabolism increased especially at birth. In perirenal adipose tissue, high mitochondrial activity was detected before birth which is a characteristic of brown adipose tissue. Furthermore, lipoprotein lipase activity and GLUT4 protein level markedly increased to reach a maximum at 6-7 and 8 months of age, and sharply decreased thereafter, whereas GLUT1 protein level increased between 6 and 7 months of age. In conclusion, considerable changes in the regulation of the insulin/glucose axis were observed from 6 months onwards of foetal development in both the heart and adipose tissue of cattle, which probably alters the potential of these tissues to use glucose or fat as energy sources.

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Insulin-like growth factor II (IGF-II) mRNA expression during skeletal muscle development of double-muscled and normal bovine foetuses

Cited by 8 publications

References 19 publications

Growth hormone receptor gene expression in the skeletal muscle of normal and double-muscled bovines during foetal development

Growth hormone receptor gene expression in the skeletal muscle of normal and double-muscled bovines during foetal development

Endocrine and metabolic regulation of muscle growth and body composition in cattle

Prenatal developmental changes in glucose transporters, intermediary metabolism and hormonal receptors related to the IGF/insulin-glucose axis in the heart and adipose tissue of bovines

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