Insulin-like growth factor (IGF) performance in ovarian function and applications in reproductive biotechnologies

Piau, Tathyana Benetis; de Queiroz Rodrigues, Aline; Paulini, Fernanda

doi:10.1016/j.ghir.2023.101561

Cited by 1 publication

(1 citation statement)

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“…Therefore, growth factors such as insulin-like growth factors (IGF1 and IGF2), which are produced by endometrial tissue, may play a role in inducing cell proliferation and differentiation [4]. The highest levels of IGF1 and IGF2 expression occur in the late and early proliferative phases, respectively [5]. Angiogenesis is an important process in the development of endometrial tissue, regulated by vascular endothelial growth factor (VEGF) [6].…”

Section: Introductionmentioning

confidence: 99%

Analysis of VEGF, IGF1/2 and the Long Noncoding RNA (lncRNA) H19 Expression in Polish Women with Endometriosis

Smolarz,

Szaflik,

Romanowicz

et al. 2024

IJMS

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The coordinated action of VEGF, IGF1/2 and H19 factors influences the development of endometriosis. The aim of this study was to analyze the expression level of these genes in patients with endometriosis. The study group consisted of 100 patients who were diagnosed with endometriosis on laparoscopic and pathological examination. The control group consisted of 100 patients who were found to be free of endometriosis during the surgical procedure and whose eutopic endometrium wasnormal on histopathological examination. These patients were operated on for uterine fibroids. Gene expression was determined by RT-PCR. The expression of the VEGF gene was significantly higher in the samples classified as clinical stage 1–2 compared to the control material (p < 0.05). There was also a statistically significant difference between the samples studied at clinical stages 1–2 and 3–4 (p < 0.01). The expression of the VEGF gene in the group classified as 1–2 was significantly higher. IGF1 gene expression was significantly lower both in the group of samples classified as clinical stages 1–2 and 3–4 compared to the control group (p < 0.05 in both cases). The expression of the H19 gene was significantly lower in the group of samples classified as clinical stage 3–4 compared to the control group (p < 0.01). The reported studies suggest significant roles of VEGF, IGF and H19 expression in the pathogenesis of endometriosis.

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Section: Introductionmentioning

confidence: 99%