Abstract:ABSTRACT. Members of the monkey species Macaca nigra spontaneously develop impairments in insulin secretion and glucose clearance, and eventually become overtly diabetic. Changes in certain metabolic signals such as clearance of glucose and insulin increment secreted in an intravenous glucose tolerance test have allowed the identification of four stages in the progression from nondiabetes to diabetes in monkeys --non-diabetic, hormonally impaired, borderline diabetic, and diabetic. Recently, another metabolic … Show more
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