Insulin‐Like Growth Factor‐I in Human Malnutrition: Relationship with Some Body Composition and Nutritional Parameters

Minuto, Francesco; Barreca, Antonina; Adami, Gian Franco; Fortini, Paola; Monte, P. Del; Cella, Franca; Scopinaro, Nicola; Giordano, Giulio

doi:10.1177/0148607189013004392

Cited by 56 publications

(23 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The anabolic mediator IGF-I has been suggested as a biochemical indicator of nutritional status (Estivariz & Ziegler, 1997;Minuto et al, 1989). However, in this set of patients serum IGF-I did not correlate to other nutritional variables.…”

Section: Discussionmentioning

confidence: 60%

The effect of nutritional intervention in elderly subjects residing in group-living for the demented

Faxén‐Irving¹,

Andrén-Olsson²,

Geijerstam³

et al. 2002

Eur J Clin Nutr

View full text Add to dashboard Cite

Objectives: We studied the nutritional status and the effects of nutritional intervention on body weight, cognition and activities of daily life (ADL)-function in demented individuals. Design: Controlled non-randomised study. Setting: Group-living for demented elderly (GLD), ie community assisted housing. Subjects and interventions: Twenty-two residents living in one of two units (GLD-I), received oral liquid supplements (1720 kJ=410 kcal=day) and the personnel of the GLD-I were given nutritional education. Fourteen residents in the other unit (GLD-C) served as controls. After 6 months 21 (83 (4) y, 81% women) and 12 (85 (4) y, 100% women) of the participants, respectively, were re-examined according to body mass index (BMI, kg=m 2 ), cognitive function (Mini Mental State Examination (MMSE, 0 -30 p) and Clinical Dementia Rating Scale (CDR) and the Katz' ADL index. Results: Body mass index (BMI) 20 was found in 19% of the participants and 44% had BMI 23. BMI correlated with MMSE (r ¼ 0.43, P < 0.01). The weight of the residents in the intervention group increased by 3.4 (3) kg (P ¼ 0.001) at follow-up, whereas the weight remained unchanged in the control group. The cognitive function was low at the start in both groups, ie MMSE 9 and no apparent positive effect of the nutritional intervention was seen. In addition, the ADL functions appeared to deteriorate in both groups. Conclusions: Being underweight was common among demented elderly in group-living and was related to low cognitive capacity. Five months of oral supplementation, along with education of personnel, was followed by a weight gain. In this study the nutritional treatment did not affect the rate of decline in cognitive function or Katz' ADL index. Sponsorship: Supported by grants from the Swedish National Board of Health and Social Welfare. Semper Foods AB provided the liquid supplements.

show abstract

Section: Discussionmentioning

confidence: 60%

The effect of nutritional intervention in elderly subjects residing in group-living for the demented

Faxén‐Irving¹,

Andrén-Olsson²,

Geijerstam³

et al. 2002

Eur J Clin Nutr

View full text Add to dashboard Cite

show abstract

“…IGF-1 correlated with each ( P < 0.02) and levels rose in six patients who were provided with nutritional support. IGF-1 has been evaluated as a nutritional index by comparing plasma concentrations with albumin, transferrin and body composition variables (total body water, total body Na and total body K) in eighteen patients who were malnourished following bilio-pancreatic bypass (Minuto, 1989). These patients were not suffering from any inflammatory response or tumour activity, and so low concentrations of IGF-1 were attributed to malnutrition alone.…”

Section: Transferrinmentioning

confidence: 99%

Problems of nutritional assessment in the acute setting

1999

Proc. Nutr. Soc.

View full text Add to dashboard Cite

Surveys have shown that 20-50 % of hospital admissions suffer from nutritional depletion and that there is failure to recognize its existence and significance. More emphasis must be placed in clinical medicine on identifying subjects who are at high risk of developing disease-related malnutrition. There is a need to screen patients on admission to hospital to identify those at risk of nutrition-related complications. More formal determination of nutritional status should be carried out to define the nutritional status of the patient and to monitor changes in nutritional status during nutritional support. The most frequently used tests of nutritional status include dietary, anthropometric, biochemical and functional indices of nutritional status. It is important, and indeed is the skill of the nutritional care team (particularly the dietitian) to be able to evaluate these measurements, as many of them are affected by non-nutritional factors. There is no consensus on the best method for the accurate assessment of nutritional status. Practical difficulties arise with individual measurements and in their interpretation in the acute setting. The aim of the present paper is to identify the most relevant variables to measure in clinical medicine, and to discuss the limitations of their use in the acute setting.

show abstract

“…activity, circulating IGF-I is receiving increasing attention as a biomarker reflecting metabolic status (6,15,18,19,28).…”

mentioning

confidence: 99%

Utility of circulating IGF-I as a biomarker for assessing body composition changes in men during periods of high physical activity superimposed upon energy and sleep restriction

Nindl¹,

Alemany²,

Kellogg³

et al. 2007

Journal of Applied Physiology

View full text Add to dashboard Cite

Young AJ, Montain SJ. Utility of circulating IGF-I as a biomarker for assessing body composition changes in men during periods of high physical activity superimposed upon energy and sleep restriction. J Appl Physiol 103: 340-346, 2007. First published April 5, 2007 doi:10.1152/japplphysiol.01321.2006.-Insulin-like growth factor (IGF)-I is a biomarker that may have greater utility than other conventional nutritional biomarkers in assessing nutritional, health, and fitness status. We hypothesized that the IGF-I system would directionally track a short-term energy deficit and would be more related to changes in body composition than other nutritional biomarkers. Thirty-five healthy men (24 Ϯ 0.3 yr) underwent 8 days of exercise and energy imbalance. Total and free IGF-I, IGF binding proteins-1, -2, and -3, the acid labile subunit, transferrin, ferritin, retinol binding protein, prealbumin, testosterone, triiodothyronine, thyroxine, and leptin responses were measured. Dual-energy X-ray absorptiometry assessed changes in body mass and composition. Repeated-measures ANOVA, correlation analysis, and receiver operator characteristic curves were used for statistical analyses (P Յ 0.05). Body mass (Ϫ3.8%), fat-free mass (Ϫ2.2%), and fat mass (Ϫ12.9%) all decreased. Total and free IGF-I, IGF binding protein-3, and the acid labile subunit and prealbumin, but not transferrin, retinol-binding protein, and ferritin, directionally tracked the energy deficit and losses in body composition. The correlation (r ϭ 0.43) between changes in free IGF-I and body and fat-free mass was the only significant association observed. Receiver operator characteristic curve analysis revealed that a baseline value Ͻ 1.67 for the molar volume ratio of IGF-I to acid labile subunit had an area under the curve of 0.745 and was a significant discriminator for those subjects losing Ͼ5% body mass. The IGF-I system is an important adjunct in the overall assessment of adaptation to stress imposed by high levels of physical activity superimposed on energy and sleep restriction and is more closely associated with losses in body mass and fat-free mass than other conventional nutritional biomarkers. somatotrophic hormones; military operation stress; nutritional biomarkers; soldier CIRCULATING INSULIN-LIKE GROWTH factor (IGF)-I is a liverderived 7.6-kDa polypeptide that plays a pivotal role in mediating metabolic, mitogenic, and anabolic cellular responses during altered energy states (1-3, 28). Due to its short half-life (2-4 h), specific and sensitive decline during negative energy balance (12,15,24,30) and protein-energy malnutrition (6,11,13,15,27), somatotrophic influences on body composition, and role in modulating the growth-promoting effect of physical activity, circulating IGF

show abstract

Insulin‐Like Growth Factor‐I in Human Malnutrition: Relationship with Some Body Composition and Nutritional Parameters

Cited by 56 publications

References 23 publications

The effect of nutritional intervention in elderly subjects residing in group-living for the demented

The effect of nutritional intervention in elderly subjects residing in group-living for the demented

Problems of nutritional assessment in the acute setting

Utility of circulating IGF-I as a biomarker for assessing body composition changes in men during periods of high physical activity superimposed upon energy and sleep restriction

Contact Info

Product

Resources

About