Insulin-Like Growth Factor I

Kooijman, Ron; Sarre, Sophie; Michotte, Yvette; Keyser, Jacques De

doi:10.1161/strokeaha.108.528356

Cited by 81 publications

(40 citation statements)

References 63 publications

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“…Due to this high expression, among the factors presently investigated, IGF-1 is thought to play a pivotal role in the amelioration of ischemic damage. The amount of the BINC-derived IGF-1, however, may be insufficient to maximize its neuroprotective ability, in view of several reports showing that exogenously administrated IGF-1 still can give marked amelioration of ischemic brain damage (Kooijman et al, 2009). As shown in Figure 5, the cell density of BINCs in the infarcted cerebellar tissue from the elderly patient was far less than that in ischemic lesions of 8-weekold rats, even though the human tissue was obtained 4 days after symptom onset when the accumulation of BINCs was not yet at its maximum.…”

Section: Discussionmentioning

confidence: 99%

Iba1⁺/NG2⁺ Macrophage-Like Cells Expressing a Variety of Neuroprotective Factors Ameliorate Ischemic Damage of the Brain

Smirkin

Matsumoto

Takahashi

et al. 2009

J Cereb Blood Flow Metab

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In a transient 90-min middle cerebral artery occlusion (MCAO) model of rats, a large ischemic lesion is formed where macrophage-like cells massively accumulate, many of which express a macrophage marker, Iba1, and an oligodendrocyte progenitor cell marker, NG2 chondroitin sulfate proteoglycan (NG2); therefore, the cells were termed BINCs (Brain Iba1 + /NG2 + Cells). A bone marrow transplantation experiment using green-fluorescent protein-transgenic rats showed that BINCs were derived from bone marrow. 5-Fluorouracil (5FU) injection at 2 days post reperfusion (2 dpr) markedly reduced the number of BINCs at 7 dpr, causing enlargement of necrotic volumes and frequent death of the rats. When isolated BINCs were transplanted into 5FU-aggravated ischemic lesion, the volume of the lesion was much reduced. Quantitative real-time RT-PCR showed that BINCs expressed mRNAs encoding bFGF, BMP2, BMP4, BMP7, GDNF, HGF, IGF-1, PDGF-A, and VEGF. In particular, BINCs expressed IGF-1 mRNA at a very high level. Immunohistochemical staining showed that IGF-1-expressing BINCs were found not only in rat but also human ischemic brain lesions. These results suggest that bone marrow-derived BINCs play a beneficial role in ischemic brain lesions, at least in part, through secretion of neuroprotective factors.

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Section: Discussionmentioning

confidence: 99%

Iba1⁺/NG2⁺ Macrophage-Like Cells Expressing a Variety of Neuroprotective Factors Ameliorate Ischemic Damage of the Brain

Smirkin

Matsumoto

Takahashi

et al. 2009

J Cereb Blood Flow Metab

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“…GH and IGF1 have many similar effects in the brain. For example, in rodents, both GH (Gustafson et al 1999, Scheepens et al 2001, Pathipati et al 2009) and IGF1 (Guan et al 2001, Lin et al 2005, Kooijman et al 2009) have been shown to protect the brain against hypoxic-ischemic (HI) injuries. Circulating IGF1 is believed to mediate some of the effects of GH on the brain (for review, see Å berg et al (2006)).…”

Section: Oprd1mentioning

confidence: 99%

Different modes of GH administration influence gene expression in the male rat brain

Walser

Schiöler

Oscarsson

et al. 2014

Journal of Endocrinology

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The endogenous secretion pattern in males of GH is episodic in rats and in humans, whereas GH administration is usually even. Different types of GH administration have different effects on body mass, longitudinal bone growth, and liver metabolism in rodents, whereas possible effects on brain plasticity have not been investigated. In this study, GH was administered as a continuous infusion or as two daily injections in hypophysectomized male rats. Thirteen transcripts previously known to respond to GH in the hippocampus and parietal cortex (cortex) were assessed by RT-PCR. To investigate the effects of type of GH administration on several transcripts with different variations, and categories of transcripts (neuron-, glia-, and GH-related), a mixed model analysis was applied. Accordingly, GH injections increased overall transcript abundance more than GH infusions (21% in the hippocampus, P!0.001 and 10% in the cortex, PZ0.09). Specifically, GH infusions and injections robustly increased neuronal hemoglobin beta (Hbb) expression significantly (1.8-to 3.6-fold), and GH injections were more effective than GH infusions in increasing Hbb in the cortex (41%, PZ0.02), whereas a 23% difference in the hippocampus was not significant. Also cortical connexin 43 was higher in the group with GH injections than in those with GH infusions (26%, P!0.007). Also, there were differences between GH injections and infusions in GH-related transcripts of the cortex (23%, PZ0.04) and glia-related transcripts of the hippocampus (15%, PZ0.02). Thus, with the exception of Hbb there is a moderate difference in responsiveness to different modes of GH administration.

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“…IGF-I has been shown to be a potent neuroprotective compound in rodent models of ischemic stroke. 1 Most of the circulating IGF-I is found in a 150 kDa complex consisting of insulin-like binding protein 3 (IGFBP3), IGF-I, and an acid-labile subunit, which transports IGF-I in the circulation and prolongs its half-life. IGF-I is available for clinical use but has not been studied in a clinical trial in patients with stroke.…”

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Insulin-Like Growth Factor I Serum Levels Influence Ischemic Stroke Outcome

Smedt

Brouns

Uyttenboogaart

et al. 2011

Stroke

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Background and Purpose— Insulin-like growth factor I (IGF-I) is neuroprotective in animal models of stroke. We investigated whether serum IGF-I levels in patients with acute ischemic stroke influence stroke severity and outcome. Methods— Concentrations of IGF-I and IGF binding protein 3 were measured in serum samples obtained within 6 hours after stroke onset from 255 patients who took part in the placebo arm of the United States and Canadian Lubeluzole in Acute Ischemic Stroke Study. Stroke severity was assessed with the National Institutes of Health Stroke Scale. Multivariate analysis was performed to assess the overall shift in modified Rankin Scale score and changes in the National Institutes of Health Stroke Scale score at 3 months. Survival curves were plotted using the Kaplan-Meier method, and the Cox proportional hazard model was used for multivariate analysis to investigate factors influencing survival. Results— After controlling for statistically relevant risk factors, subjects with high IGF-I levels or IGF-I/IGF binding protein 3 ratios had a better neurological and functional outcome at 3 months. Baseline stroke severity was not different between high and low IGF-I groups. In contrast to the low IGF-I group, neurological symptoms gradually improved from Day 3 in the high IGF-I group. Conclusions— Our results suggest that high serum IGF-I levels just after ischemic stroke onset are associated with neurological recovery and a better functional outcome.

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Insulin-Like Growth Factor I

Cited by 81 publications

References 63 publications

Iba1⁺/NG2⁺ Macrophage-Like Cells Expressing a Variety of Neuroprotective Factors Ameliorate Ischemic Damage of the Brain

Iba1⁺/NG2⁺ Macrophage-Like Cells Expressing a Variety of Neuroprotective Factors Ameliorate Ischemic Damage of the Brain

Different modes of GH administration influence gene expression in the male rat brain

Insulin-Like Growth Factor I Serum Levels Influence Ischemic Stroke Outcome

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Insulin-Like Growth Factor I

Cited by 81 publications

References 63 publications

Iba1+/NG2+ Macrophage-Like Cells Expressing a Variety of Neuroprotective Factors Ameliorate Ischemic Damage of the Brain

Iba1+/NG2+ Macrophage-Like Cells Expressing a Variety of Neuroprotective Factors Ameliorate Ischemic Damage of the Brain

Different modes of GH administration influence gene expression in the male rat brain

Insulin-Like Growth Factor I Serum Levels Influence Ischemic Stroke Outcome

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Iba1⁺/NG2⁺ Macrophage-Like Cells Expressing a Variety of Neuroprotective Factors Ameliorate Ischemic Damage of the Brain

Iba1⁺/NG2⁺ Macrophage-Like Cells Expressing a Variety of Neuroprotective Factors Ameliorate Ischemic Damage of the Brain