Insulin-like Growth Factor Binding Proteins in Cerebrospinal Fluid during Human Development and Aging

Arnold, Paul M.; Jianxin, Y.; Citron, Bruce A.; Festoff, Barry W.

doi:10.1006/bbrc.1999.1555

Cited by 19 publications

(9 citation statements)

References 51 publications

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“…Moreover, CSF contains concentrations of neurotransmitters and neuropeptides. A number of studies have identified CSF as a carrier of important cytokines, such as transforming growth factor (TGF-b), nerve growth factor (NGF), BDNF, neurotrophin 3 (NT-3), IGF and GDNF, which are present at specific times during development under specific physiological conditions or challenges [23,[30][31][32][33][34][35][36][37]. Thus, it is probable that the CSF contains growth regulators that have the potential to affect the function of the fetal germinal epithelium.…”

Section: Discussionmentioning

confidence: 99%

The importance of cerebrospinal fluid on neural cell proliferation in developing chick cerebral cortex

Mashayekhi

Salehi

2006

Euro J of Neurology

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Cerebrospinal fluid (CSF) is mainly produced by the choroid plexuses within the ventricles of the brain. The CSF circulates in a regular manner after the ventricular system and the choroids plexuses have developed, and the foramina in the fourth ventricle have opened to enable it to carry chemical information. CSF flows through the ventricular system passing over all regions of germinal activity. In this study, chick embryos were used to show the importance of CSF on neural cell proliferation in the developing cerebral cortex. The chick embryos were cannulated in situ with a fine capillary tube to drain CSF out of the ventricular system. At the same time, BrdU was administered to the embryos. After surgery the embryos were incubated for another 3 days. Quantitative measurements showed that the thicknesses of the germinal epithelium and cerebral cortex in CSF-drained embryos were less than those in the control group at the same age. The number of cells produced in the germinal epithelium of CSF-drained embryos was decreased when compared with the normal group. This study provides confirmatory evidence that CSF is important for neural cell proliferation and therefore normal development of the cerebral cortex. It is proposed that CSF is vital in controlling development of the cerebral cortex.

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Section: Discussionmentioning

confidence: 99%

The importance of cerebrospinal fluid on neural cell proliferation in developing chick cerebral cortex

Mashayekhi

Salehi

2006

Euro J of Neurology

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“…, 2001), brain derived neurotrophic factor (BDNF), neurotrophin‐3 (NT‐3) (Xia et al. , 2000), insulin‐like growth factor (IGF) (Arnold et al. , 1999) to be present at specific times during development or under specific physiological conditions in CSF.…”

Section: Introductionmentioning

confidence: 99%

“…In agreement with our results, there is now a body of evidence that point towards a critical role of CSF in brain development and physiology. CSF contains growth factors and cytokines secreted from the choroids plexus as well as subcommissural organ (Schoniger et al, 2002) which are known modulators of neurogenesis, differentiation and the brain extracellular microenvironment and show changes associated with neurological disorders and disorders of development (Kasaian and Neet, 1989;Jones et al, 1991;Kitazawa and Tada, 1994;Suzuki et al, 1997;Arnold et al, 1999;Johanson et al, 1999;Nicholson, 1999;Moinuddin and Tada, 2000;Xia et al, 2000;Johanson and Jones, 2001). A number of studies have found important cytokines such as transforming growth factor-beta (TGF-b), nerve growth factor (NGF) (Hochhaus et al, 2001), brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) (Xia et al, 2000), insulin-like growth factor (IGF) (Arnold et al, 1999) to be present at specific times Correspondence: F. Mashayekhi, Department of Biology, The University of Guilan, Rasht, Iran (tel.…”

Section: Introductionmentioning

confidence: 99%

Expression of nerve growth factor in cerebrospinal fluid of congenital hydrocephalic and normal children

Mashayekhi

Salehi

2005

Euro J of Neurology

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Cerebrospinal fluid (CSF) is secreted by the choroids plexuses and has the potential to act as a signaling pathway for physiological control as it has been demonstrated to contain molecules such as interleukins, leukoterins, neuropeptides, growth transforming factor-beta (TGF-beta) and nerve growth factor (NGF), which are present at specific times during development. In this study, CSF from hydrocephalic and normal children were analysed using SDS-PAGE followed by silver staining. In order to obtain semi-quantitative estimates of the relative amounts of 26 kDa protein, an image analyzer was used to determine the intensities of the band in the respective lanes in silver-stained gels. Quantification of the silver-stained gels from repeated experiments showed that the amount of 26 kDa protein was clearly increases in the hydrocephalic CSF when compared with the normal CSF. A Western blot analysis using anti-NGF antibody as a probe confirmed the presence of NGF. Using enzyme-linked immunosorbent assay (ELISA), it was shown that the level of NGF in the hydrocephalic CSF is higher than in normal CSF. It is concluded that NGF is not only a constant component of human CSF but could also be significantly involved in the pathophysiology of hydrocephalus.

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“…Reports of aging-related effects on IGFBP-3, which binds 90% of circulating IGF-I, are conflicting [83,88]. In CSF, levels of IGFBP-2, the primary neuronal IGFBP, remain constant during aging, whereas IGFBP-3 levels increase greatly [89]. As with the binding proteins, aging-related regulation of the IGF-IR is still unclear.…”

Section: Dendritic Analysismentioning

confidence: 99%

Dendritic stability in a model of adult-onset IGF-I deficiency

Grill

Sonntag

Riddle

2005

Growth Hormone & IGF Research

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Insulin-like Growth Factor Binding Proteins in Cerebrospinal Fluid during Human Development and Aging

Cited by 19 publications

References 51 publications

The importance of cerebrospinal fluid on neural cell proliferation in developing chick cerebral cortex

The importance of cerebrospinal fluid on neural cell proliferation in developing chick cerebral cortex

Expression of nerve growth factor in cerebrospinal fluid of congenital hydrocephalic and normal children

Dendritic stability in a model of adult-onset IGF-I deficiency

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