Insulin-Like Growth Factor-Binding Protein (IGFBP)-1, -2, -3, -4, -5, and -6 and IGFBP-Related Protein 1 during Rainbow Trout Postvitellogenesis and Oocyte Maturation: Molecular Characterization, Expression Profiles, and Hormonal Regulation

Kamangar, Barzan Bahrami; Gabillard, Jean-Charles; Bobe, Julien

doi:10.1210/en.2005-1570

Cited by 106 publications

(67 citation statements)

References 38 publications

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“…Kamangar et al (2006) claimed the isolation of the six igfbps in rainbow trout. Nevertheless, in this publication, Figure 4 Transcriptional regulation of the igfbps in the skeletal muscle of the fine flounder during short-term refeeding.…”

Section: Discussionmentioning

confidence: 99%

Dynamic transcriptional regulation of autocrine/paracrine igfbp1, 2, 3, 4, 5, and 6 in the skeletal muscle of the fine flounder during different nutritional statuses

Safian

Fuentes

Valdés³

et al. 2012

Journal of Endocrinology

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The IGF-binding proteins (IGFBPs) play a dual role in the regulation of the activity and bioavailability of IGFs in different tissues. Diverse evidence has shown that IGFBPs can inhibit and/or potentiate IGF actions. In this study, igfbp1, 2, 3, 4, 5, and 6 were isolated in the fine flounder, a flat fish species that shows slow growth and inherent Gh resistance in muscle. Subsequently, the expression of all igfbps was assessed in the skeletal muscle of flounder that underwent different nutritional statuses. igfbp1 was not expressed in muscle during any of the nutritional conditions, whereas igfbp3 and igfbp5 were the lowest and the highest igfbps expressed respectively. A dynamic expression pattern was found in all the igfbps expressed in skeletal muscle, which depended on the nutritional status and sampling period. During the fasting period, igfbp2, 4, and 5 were downregulated, whereas igfbp3 was upregulated during part of the fasting period. The restoration of food modulated the expression of the igfbps dynamically, showing significant changes during both the long-and short-term refeeding. igfbp3 and igfbp6 were downregulated during short-term refeeding, whereas igfbp5 was upregulated, and igfbp2 and igfbp4 remained stable. During long-term refeeding, the expression of igfbp2, 4, 5, and 6 increased, while igfbp3 remained unchanged. In conclusion, this study shows for the first time the isolation of all igfbps in a single fish species, in addition to describing a dynamic nutritional and time-dependent response in the expression of igfbps in the skeletal muscle of a nonmammalian species.

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Section: Discussionmentioning

confidence: 99%

Dynamic transcriptional regulation of autocrine/paracrine igfbp1, 2, 3, 4, 5, and 6 in the skeletal muscle of the fine flounder during different nutritional statuses

Safian

Fuentes

Valdés³

et al. 2012

Journal of Endocrinology

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“…The less likely alternative explanation, extreme functional divergence of a common ancestor, cannot be entirely excluded without further analysis, especially given the very early divergence of IGFBPs and IGFBP-rPs. Kamangar et al (2006) recently characterized several cDNA clones for all six rainbow trout IGFBP homologs and IGFBP-rP1. This includes a putative IGFBP-3 that segregated along with IGFBP-2 orthologs in our phylogenetic analysis.…”

Section: Discussionmentioning

confidence: 99%

“…1) contained only orthologs for that specific IGFBP with one exception. A recently identified rainbow trout IGFBP-3 homolog segregated within the IGFBP-2 subclade rather than with the IGFBP-3 subclade, suggesting that this particular homolog is actually an IGFBP-2 paralog as another rainbow trout IGFBP-2 was also characterized (Kamangar et al, 2006). The true identity of the putative IGFBP-3 was therefore determined by comparative alignments and subsequence analysis.…”

Section: Identification Of a Novel Rainbow Trout Igfbp-2 Paralogmentioning

confidence: 99%

Phylogenetic analysis of the insulin-like growth factor binding protein (IGFBP) and IGFBP-related protein gene families

Rodgers

Roalson

Thompson

2008

General and Comparative Endocrinology

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Insulin-like growth factor (IGF) activity is regulated by six high affinity binding proteins (IGFBPs) and possibly by some of the nine IGFBP-related proteins (IGFBP-rPs). To determine the phylogenetic relationship of this proposed gene superfamily, we conducted maximum likelihood (ML) and Bayesian inference analyses on a matrix of amino acid sequences from a diversity of vertebrate species. A single most likely phylogram, ML bootstrap, and Bayesian consensus tree of 10,000,000 generations revealed a monophyletic IGFBP lineage independent of the IGFBP-rPs. The IGFBPs segregated into three distinct clades: IGFBP-1, -3, and -6. Subsequent gene duplication events within the IGFBP-1 and -3 clades resulted in the production and divergence of IGFBP-2 and -4 within the IGFBP-1 clade and IGFBP-5 in the IGFBP-3 clade. By contrast, the IGFBP-rPs were distributed paraphyletically into two clades: IGFBP-rP1, 5, and 6 in one clade and the CCN family (IGFBPrP2-4,7-9) in another. A recently identified IGFBP-3 homolog in rainbow trout localized to the IGFBP-2 subclade. Subsequence analysis identified a RGD motif common to IGFBP-2 orthologs, but did not identify the nuclear localization sequence present in IGFBP-3 and -5 homologs. The putative trout IGFBP-3 was 36-55% identical to different IGFBP-2 proteins, but only 24-27% identical to IGFBP-3 proteins. These results suggest that the IGFBPs and IGFBP-rPs are at best distantly related and that the limited similarities likely resulted from exon shuffling. They also suggest that rainbow trout, and possibly other salmonids, possess two IGFBP-2 paralogs as the putative trout IGFBP-3 is misannotated.

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“…In addition to E 2 endocrine effects, E 2 may have autocrine and/or paracrine effects, as E 2 inhibits follicle-enclosed oocyte maturation through inhibition of maturation-inducing steroid (MIS) synthesizing enzymes in vitellogenic species such as Rana pipiens (Schuetz 1972, Spiegel et al 1978, Lin & Schuetz 1983 or Oncorhynchus mykiss ( Jalabert et al 1984). This steroid may also activate transcription of particular genes within the oocyte that would play a role in oocyte development, such as IGFBP3, the expression of which has been shown to be positively regulated by E 2 in trout oocytes (Kamangar et al 2006). E 2 is synthesized by the cytochrome P450 aromatase enzyme that converts androstenedione and testosterone into estrone (E1) and E 2 respectively.…”

Section: Introductionmentioning

confidence: 99%

Aromatase expression in Xenopus oocytes: a three cell-type model for the ovarian estradiol synthesis

Gohin¹,

Bodinier²,

Fostier³

et al. 2011

Journal of Molecular Endocrinology

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In contrast to the classical model describing the synthesis of androgens and estrogens as restricted to somatic cells, a previous study demonstrated that Xenopus laevis oocytes participate in androgen synthesis. The objective of our study was to determine whether Xenopus oocytes are also involved in estrogen synthesis. More precisely, we analyzed aromatase expression by in situ hybridization and RT-QPCR and measured aromatase activity. Aromatase, the enzyme responsible for estrogen synthesis, appears to be expressed and active not only in the follicular cells but also in the vitellogenic oocytes. During late oogenesis, aromatase oocyte expression and activity decreased concomitantly with the trend observed in surrounding follicular layers. In order to investigate the role of estradiol-17b (E 2 ), we studied its effect on oocyte meiotic resumption. It appears that, as in Rana pipiens, E 2 inhibited the follicle-enclosed maturation of Xenopus oocytes, likely through inhibition of LH-induced maturation-inducing steroid synthesis. In addition, E 2 exerted a slight enhancing action on denuded oocyte maturation whose biological significance remains unclear. Together, our results demonstrate that Xenopus oocyte significantly participates in ovarian E 2 synthesis and this may be a common feature of vitellogenic vertebrates.

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Insulin-Like Growth Factor-Binding Protein (IGFBP)-1, -2, -3, -4, -5, and -6 and IGFBP-Related Protein 1 during Rainbow Trout Postvitellogenesis and Oocyte Maturation: Molecular Characterization, Expression Profiles, and Hormonal Regulation

Cited by 106 publications

References 38 publications

Dynamic transcriptional regulation of autocrine/paracrine igfbp1, 2, 3, 4, 5, and 6 in the skeletal muscle of the fine flounder during different nutritional statuses

Dynamic transcriptional regulation of autocrine/paracrine igfbp1, 2, 3, 4, 5, and 6 in the skeletal muscle of the fine flounder during different nutritional statuses

Phylogenetic analysis of the insulin-like growth factor binding protein (IGFBP) and IGFBP-related protein gene families

Aromatase expression in Xenopus oocytes: a three cell-type model for the ovarian estradiol synthesis

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