Insulin-Like Growth Factor Binding Protein 6 Is Secreted in Extracellular Vesicles upon Hyperthermia and Oxidative Stress in Dendritic Cells But Not in Monocytes

Conese, Massimo; Pace, Lorenzo; Pignataro, Nicoletta; Catucci, Lucia; Ambrosi, Antonio; Gioia, Sante Di; Tartaglia, Nicola; Liso, Arcangelo

doi:10.3390/ijms21124428

Cited by 8 publications

(4 citation statements)

References 29 publications

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“…Intriguingly, IGFBP-6 is also an acute-phase protein, as demonstrated by our and other groups in experiments showing that it is rapidly produced in response to damage after DCs and fibroblast exposure to H 2 O 2 [21]. Particularly, H 2 O 2 induces a dose-dependent up-regulation of IGFBP-6 mRNA and protein levels in skin diploid fibroblasts exposed to a sublethal dose of H 2 O 2 [22].…”

Section: Igfbp-6 Has An Important Role In the Immune Responsesupporting

confidence: 57%

IGFBP-6: At the Crossroads of Immunity, Tissue Repair and Fibrosis

Liso

Venuto

Coda

et al. 2022

IJMS

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Insulin-like growth factors binding protein-6 (IGFBP-6) is involved in a relevant number of cellular activities and represents an important factor in the immune response, particularly in human dendritic cells (DCs). Over the past several years, significant insights into the IGF-independent effects of IGFBP-6 were discovered, such as the induction of chemotaxis, capacity to increase oxidative burst and neutrophils degranulation, ability to induce metabolic changes in DCs, and, more recently, the regulation of the Sonic Hedgehog (SHH) signaling pathway during fibrosis. IGFBP-6 has been implicated in different human diseases, and it plays a rather controversial role in the biology of tumors. Notably, well established relationships between immunity, stroma activity, and fibrosis are prognostic and predictive of response to cancer immunotherapy. This review aims at describing the current understanding of mechanisms that link IGFBP-6 and fibrosis development and at highlighting the multiple roles of IGFBP-6 to provide an insight into evolutionarily conserved mechanisms that can be relevant for inflammation, tumor immunity, and immunological diseases.

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Section: Igfbp-6 Has An Important Role In the Immune Responsesupporting

confidence: 57%

IGFBP-6: At the Crossroads of Immunity, Tissue Repair and Fibrosis

Liso

Venuto

Coda

et al. 2022

IJMS

Self Cite

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“…Likewise, genetically high levels of N -acetylarginine decrease the levels of IGFBP-6. IGFBP-6 has cancer-protective properties, plays a role in the immune system 60 , 61 and in neuronal protection 62 . N -acetylarginine is a guanidino compound that is capable of inducing seizures in animal experiments; 63 high levels of this compound present in argininemia that is characterized by neurological symptoms 64 .…”

Section: Discussionmentioning

confidence: 99%

Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations

Feofanova,

Brown,

Alkis

et al. 2023

Nat Commun

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Circulating metabolite levels may reflect the state of the human organism in health and disease, however, the genetic architecture of metabolites is not fully understood. We have performed a whole-genome sequencing association analysis of both common and rare variants in up to 11,840 multi-ethnic participants from five studies with up to 1666 circulating metabolites. We have discovered 1985 novel variant-metabolite associations, and validated 761 locus-metabolite associations reported previously. Seventy-nine novel variant-metabolite associations have been replicated, including three genetic loci located on the X chromosome that have demonstrated its involvement in metabolic regulation. Gene-based analysis have provided further support for seven metabolite-replicated loci pairs and their biologically plausible genes. Among those novel replicated variant-metabolite pairs, follow-up analyses have revealed that 26 metabolites have colocalized with 21 tissues, seven metabolite-disease outcome associations have been putatively causal, and 7 metabolites might be regulated by plasma protein levels. Our results have depicted the genetic contribution to circulating metabolite levels, providing additional insights into understanding human disease.

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“…IGFBP-6 is a critical member of the IGF family and widely exists in human tissues, cells, and body fluids; it can bind to IGF-2 and inhibit the physiological function of promoting cell growth, proliferation, and differentiation mediated by IGF-2 [ 32 ]. IGFBP-6 could promote cell migration and regulate neutrophil activity, which suggests regulating inflammatory immune response and oxidative stress [ 33 , 34 ]. Some studies have indicated that IGFBP-6 could inhibit tumor angiogenesis in multiple systems through the IGF-2-independent pathway [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Integrated Analysis of Multiomics Data Identified Molecular Subtypes and Oxidative Stress-Related Prognostic Biomarkers in Glioblastoma Multiforme

2022

Oxidative Medicine and Cellular Longevity

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Glioblastoma multiforme (GBM) is a glioma in IV stage, which is one of the most common primary malignant brain tumors in adults. GBM has the characters of high invasiveness, high recurrence rate, and low survival rate and with a poor prognosis. GBM implicates various genetic changes and epigenetic and gene transcription disorders, which are crucial in developing GBM. With the progression and enhancement of high-throughput sequencing technologies, the acquirement and administering approaches of diverse biological omics data on distinctive levels are developing more advanced. However, the research of GBM with multiomics remains largely unknown. We identified GBM-related molecular subtypes by integrated multiomics data and exploring the connections of gene copy number variation (CNV) and methylation gene (MET) change data. The expression of CNV and MET genes was examined through cluster integration analysis. The present study confirmed three clusters (iC1, iC2, and iC3) with distinctive prognosis and molecule peculiarities. We also recognized three oxidative stress protecting molecules (OSMR, IGFBP6, and MYBPH) by contrasting gene expression, MET, and CNV in the three subtypes. OSMR, IGFBP6, and MYBPH were differentially expressed in the clusters, suggesting they might be recognized as characteristic markers for the three clusters in GBM. Through integrative investigation of genomics, epigenomics, and transcriptomics, we offer novel visions into the multilayered molecules of GBM and facilitate the accuracy remedy for GBM sufferers.

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Insulin-Like Growth Factor Binding Protein 6 Is Secreted in Extracellular Vesicles upon Hyperthermia and Oxidative Stress in Dendritic Cells But Not in Monocytes

Cited by 8 publications

References 29 publications

IGFBP-6: At the Crossroads of Immunity, Tissue Repair and Fibrosis

IGFBP-6: At the Crossroads of Immunity, Tissue Repair and Fibrosis

Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations

Integrated Analysis of Multiomics Data Identified Molecular Subtypes and Oxidative Stress-Related Prognostic Biomarkers in Glioblastoma Multiforme

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