2004
DOI: 10.1016/j.ghir.2004.02.002
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Insulin-like growth factor binding protein (IGFBP) signalling

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Cited by 49 publications
(39 citation statements)
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References 64 publications
(95 reference statements)
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“…They include induction and activation of Stat1 (38), phosphorylation of Smad2 and -3 (55,81), and stimulation of phosphotyrosine phosphatase or phosphatidylinositol 3-kinase and increasing intracellular Ca 2ϩ (reviewed in Ref. 43). Antisense oligonucleotide to Stat1 blocked IGFBP-3-induced apoptosis in a rat chon- A, Pre-YFP-IGFBP-3 is synthesized on ribosomes in the rough endoplasmic reticulum.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…They include induction and activation of Stat1 (38), phosphorylation of Smad2 and -3 (55,81), and stimulation of phosphotyrosine phosphatase or phosphatidylinositol 3-kinase and increasing intracellular Ca 2ϩ (reviewed in Ref. 43). Antisense oligonucleotide to Stat1 blocked IGFBP-3-induced apoptosis in a rat chon- A, Pre-YFP-IGFBP-3 is synthesized on ribosomes in the rough endoplasmic reticulum.…”
Section: Discussionmentioning
confidence: 99%
“…IGFBP-3 activates several signal transduction pathways (reviewed in Ref. 43), but a functional role only has been demonstrated for Stat1 (signal transducer and activator of transcription 1), which is required for IGFBP-3-induced apoptosis in rat chondroprogenitor cells (38).…”
mentioning
confidence: 99%
“…In addition, integrins coopt GFR signaling pathways by directly acting on downstream components of the pathways via enzymatic actions of proteins recruited to integrin cytoplasmic tails. Finally, a different form of cross talk involves integrins interacting with extracellular GFs (Hutchings et al 2003;Vlahakis et al 2007), GF binding proteins (Munger et al 1998;Ricort 2004), and soluble GFR (Soro et al 2008).…”
Section: Cross Talk Between Integrins and Growth Factorsmentioning
confidence: 99%
“…Internalisation of IGFBP3 is dependent on binding to either caveolae (Lee et al, 2004;Singh et al, 2004) shown to be controlled by importin-p (Schedlich et al, 2000). The functions of these binding proteins on translocation to the nucleus are not well characterised but appear to involve regulation o f transcription and therefore could lead to IGFBP dependent cellular effects such as apoptosis (Ricort, 2004). …”
Section: Igfbp3 Andmentioning
confidence: 99%