Insulin-like growth factor-binding protein-1 inhibits binding of IGF-I on fetal skin fibroblasts but stimulates their DNA synthesis

Koistinen, Riitta; Itkonen, Outi; Selenius, P.; Seppälä, Markku

doi:10.1016/s0006-291x(05)81073-3

Cited by 47 publications

(17 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IGFBP-1, in the presence of low concentration of platelet-poor plasma and IGF-I, stimulated DNA synthesis in porcine aortic smooth muscle cells, chick embryo fibroblasts, and mouse embryo fibroblasts [121, 122]. Koistinen et al [123]concluded that IGFBP-1 caused slow and steady release of IGF-I when they found that concentrations that can inhibit binding of IGF-I to its receptor sometimes enhance IGF-stimulated thymidine incorporation. The inhibition did not occur when IGFBP-1 was added without IGF-I, suggesting an effect due to the slow release of IGF-I and not due to a direct effect of IGFBP-1 [123, 124].…”

Section: Igf Stimulatory Roles Of Igfbpsmentioning

confidence: 99%

Insulin-Like Growth Factor Binding Proteins: New Proteins, New Functions

1999

View full text Add to dashboard Cite

The insulin-like growth factors (IGFs), IGF binding proteins (IGFBPs), and IGFBP proteases regulate somatic growth and cellular proliferation both in vivo and in vitro. IGFs are potent mitogens whose actions are determined by the availability of free IGFs to interact with IGF receptors. IGFBPs comprise a family of six proteins that bind IGFs with high affinity and specificity and thereby regulate IGF-dependent actions. IGFBPs have recently emerged as IGF-independent regulators of cell growth. Cleavage of IGFBPs by specific proteases modulate levels of free IGFs and IGFBPs and thereby their actions. IGFBP-related proteins (IGFBP-rPs) bind IGFs with low affinity and also play important roles in cell growth and differentiation. The GH-IGF-IGFBP axis is complex and powerful. Future research on its physiology promises exciting insights into cell biology as well as therapies for diseases such as cancer and diabetes mellitus.

show abstract

Section: Igf Stimulatory Roles Of Igfbpsmentioning

confidence: 99%

Insulin-Like Growth Factor Binding Proteins: New Proteins, New Functions

1999

View full text Add to dashboard Cite

show abstract

“…IGFBP-1, in the presence of low concentration of platelet-poor plasma and IGF-I, stimulated DNA synthesis in porcine aortic smooth muscle cells, chick embryo fibroblasts, and mouse embryo fibroblasts [121,122]. Koistinen et al concluded that IGFBP-1 caused slow and steady release of IGF-I when they found that concentrations that can inhibit IGF-I's binding to its receptor sometimes enhance IGF-stimulated thymidine incorporation [123]. The inhibition did not occur when IGFBP-1 was added without IGF-I, suggesting an effect due to the slow release of IGF-I and not due to a direct effect of IGFBP-1 [123,124].…”

Section: Igf Stimulatory Roles Of Igfbpsmentioning

confidence: 99%

“…Koistinen et al concluded that IGFBP-1 caused slow and steady release of IGF-I when they found that concentrations that can inhibit IGF-I's binding to its receptor sometimes enhance IGF-stimulated thymidine incorporation [123]. The inhibition did not occur when IGFBP-1 was added without IGF-I, suggesting an effect due to the slow release of IGF-I and not due to a direct effect of IGFBP-1 [123,124].…”

Section: Igf Stimulatory Roles Of Igfbpsmentioning

confidence: 99%

Cellular Actions of Insulin-Like Growth Factor Binding Proteins

Ferry

Katz²,

Grimberg³

et al. 1999

Horm Metab Res

142

View full text Add to dashboard Cite

The insulin-like growth factors (IGFs), insulin-like growth factor binding proteins (IGFBPs), and the IGFBP proteases are involved in the regulation of somatic growth and cellular proliferation both in vivo and in vitro. IGFs are potent mitogenic agents whose actions are determined by the availability of free IGFs to interact with the IGF receptors. IGFBPs comprise a family of proteins that bind IGFs with high affinity and specificity and thereby regulate IGF-dependent actions. IGFBPs have recently emerged as IGF-independent regulators of cell growth. Various IGFBP association proteins as well as cleavage of IGFBPs by specific proteases modulate levels of free IGFs and IGFBPs. The ubiquity and complexity of the IGF axis promise exciting discoveries and applications for the future.

show abstract

“…Maybe IGFBPs work as antimitogens and IGFs are potential promotors of cancer growth (Zapf, 1995). Koistinen et al (1990) purified two peaks of IGFBP-1 with the same molecular weight of 30 kDa from the midtrimestral human amniotic fluid. This BP caused the inhibition of 125 I-IGF binding to fetal skin fibroblasts, on the other hand it increased IGF-I stimulated 3 H-thymidine incorporation into DNA of the same cells but not membrana granulosa cells.…”

Section: Inhibition Of Igfs Effectsmentioning

confidence: 99%