Insulin-like growth factor binding protein-1 (IGFBP-1): a multifunctional role in the human female reproductive tract

Fowler, Darren J.; Nicolaides, Kypros H.; Miell, John P.

doi:10.1093/humupd/6.5.495

Cited by 87 publications

(75 citation statements)

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“…67 IGFBP1 modulates the effects of IGF1 and IGF2, which have important roles in vessel growth. 68 Leptin targets the vascular endothelium and induces neovascularization in vivo. 69 MCP1 levels increase in the thrombus as it resolves, and increasing the amount of MCP1 in the thrombus enhances thrombus organization and resolution.…”

Section: Evans Et Al Hypoxia and Venous Thrombus Resolutionmentioning

confidence: 99%

Hypoxia and Upregulation of Hypoxia-Inducible Factor 1α Stimulate Venous Thrombus Recanalization

Evans

Humphries

Mattock

et al. 2010

ATVB

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Section: Evans Et Al Hypoxia and Venous Thrombus Resolutionmentioning

confidence: 99%

Hypoxia and Upregulation of Hypoxia-Inducible Factor 1α Stimulate Venous Thrombus Recanalization

Evans

Humphries

Mattock

et al. 2010

ATVB

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“…The IG-FBP1 protein is involved in regulating the menstrual cycle, ovulation, implantation, and fetal growth (Fowler et al, 2000). In humans, IGFBP1 serum concentrations are decreased in polycystic ovarian syndrome, which causes menstrual disturbance and anovulatory infertility (Fowler et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Effect of polymorphisms in candidate genes on reproduction traits in Finnish pig populations1

Sironen

Uimari

Serenius³

et al. 2010

Journal of Animal Science

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Reproduction traits play an important role in economically viable piglet production and are closely related to the quality and length of the productive life of the sow. A increased removal rate of young sows is undesirable not only because of the associated financial penalties incurred, but also because of ethical concerns. Candidate genes and gene pathways have been identified for fertility in model species, and recent studies have provided evidence that polymorphisms within these genes are associated with reproduction traits in American Yorkshire/Large White and Landrace populations. In this study we evaluated the impact of single polymorphisms (n = 7) in 7 candidate genes on reproductive efficiency in Finnish Yorkshire (n = 280) and Landrace (n = 271) populations: IGFBP1, IGFBP2, IGFBP3, IGFBP5, CPTIA (carnitine Opalmitoyltransferase I), COX2 (PG-endoperoxide synthase 2, also known as cyclooxygenase-2), and SLC22A5 [organic cation/carnitine transporter 2 (solute carrier family member I), OCTN2]. In the Finnish Yorkshire population, only 4 of the analyzed markers were polymorphic. Significant effects on farrowing time were detected from the Yorkshire data, with polymorphisms within the genes CPT1A [a (allele substitution effect of allele A) = 2.97 d for age at first farrowing)], IGFBP3 (a = 0.54 d for farrowing interval of parities >1), and IGFBP5 (a = 3.22, 1.27, and 0.85 d for age at first farrowing and farrowing interval in the first and later parities, respectively). For the Landrace population, 6 markers were polymorphic, and significant effects were detected for traits affecting litter size. The polymorphism within the COX2 gene had an additive effect of 0.3 piglets for litter size in parities >1, and the IGFBP1 gene had an additive effect of 0.21, 0.26, and 0.11 piglets for litter size in the first parity, parities >1, and stillborn in parities >1, respectively. The additive effect of the SNP within the IGFBP2 gene was 0.16, 0.09, and 0.09 piglets for litter size in parities >1 and stillborn in the first and later parities, respectively. Finally, the IGFBP5 gene had an additive effect of 0.18, 0.07, and 0.07 piglets for litter size in the first parity, stillborn in parities >1, and mortality between farrowing and weaning in the first parity, respectively. These results support the suitability of the candidate gene approach for identification of markers to improve the reproductive performance of sows and to provide potential markers for marker-assisted selection. ABSTRACT: Reproduction traits play an important role in economically viable piglet production and are closely related to the quality and length of the productive life of the sow. A increased removal rate of young sows is undesirable not only because of the associated financial penalties incurred, but also because of ethical concerns. Candidate genes and gene pathways have been identified for fertility in model species, and recent studies have provided evidence that polymorphisms within these genes are associated with reproduction traits ...

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“…The function of IGF-II: IGF-BP1 at the feto-maternal interface involve balance between invasion and its suppression to achieve normal implantation and placental development. 53,54 Apart from these factors, there are many others which have been studied to be regulated during endometrial receptivity.…”

Section: Functional Parameter Of Endometrial Receptivitymentioning

confidence: 99%

Endometrial Receptivity and Human Embryo Implantation

Rashid

Lalitkumar

et al. 2011

American J Rep Immunol

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Citation Rashid NA, Lalitkumar S, Lalitkumar PG, Gemzell‐Danielsson K. Endometrial Receptivity and Human Embryo Implantation. Am J Reprod Immunol 2011; 66 (Suppl. 1): 23–30Problem The pre‐requisite of successful implantation involves an intricate cascade of molecular interactions which plays a crucial role in preparing receptive endometrium and implanting blastocyst.Method of study Data are hereby presented for a better understanding of endometrial receptivity in women, hoping to provide a comprehensive picture of the process and identify new areas of basic and translational research in the biology of blastocyst implantation.Results Timely regulation of the expression of a number of complex molecules like hormones, cytokines and growth factors, and their crosstalk from embryonic and maternal endometrial side play a major role in determining the fate of the embryo. The molecular basis of endometrial receptivity and the mechanisms by which the blastocyst first adheres to the luminal epithelium and then penetrates into the stroma are only just beginning to be resolved.Conclusion Advances in the development of implantation models and ‘omics’ technologies, particularly proteomics and metabolomics, are set to have a major impact on the development of this field.

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Insulin-like growth factor binding protein-1 (IGFBP-1): a multifunctional role in the human female reproductive tract

Cited by 87 publications

References 0 publications

Hypoxia and Upregulation of Hypoxia-Inducible Factor 1α Stimulate Venous Thrombus Recanalization

Hypoxia and Upregulation of Hypoxia-Inducible Factor 1α Stimulate Venous Thrombus Recanalization

Effect of polymorphisms in candidate genes on reproduction traits in Finnish pig populations1

Endometrial Receptivity and Human Embryo Implantation

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