Insulin-like growth factor 1 of wild vertebrates in a life-history context

Lodjak, Jaanis; Verhulst, Simon

doi:10.1016/j.mce.2020.110978

Cited by 26 publications

(32 citation statements)

References 181 publications

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“…Genetic variation of the gene IGF1 played for example a large role in the evolution of body size among dog breeds ( Sutter et al, 2007 ), and variation in IGF1 is an important mediator of life-history variation among vertebrates ( Lodjak and Verhulst, 2020 ). We demonstrated that the time-specific and sex-specific expression of this gene may play an important role in the development of SSD in reptiles.…”

Section: Discussionmentioning

confidence: 99%

Development of male-larger sexual size dimorphism in a lizard: IGF1 peak long after sexual maturity overlaps with pronounced growth in males

Meter

Kratochvíl²,

Kubička³

et al. 2022

Front. Physiol.

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Squamate reptiles have been considered to be indeterminate growers for a long time. However, recent studies demonstrate that bone prolongation is stopped in many lizards by the closure of bone growth plates. This shift in the paradigm of lizard growth has important consequences for questions concerning the proximate causes of sexual size dimorphism. The traditional model of highly plastic and indeterminate growth would correspond more to a long-term action of a sex-specific growth regulator. On the other hand, determinate growth would be more consistent with a regulator acting in a sex-specific manner on the activity of bone growth plates operating during the phase when a dimorphism in size develops. We followed the growth of males and females of the male-larger Madagascar ground gecko (Paroedura picta) and monitored the activity of bone growth plates, gonad size, levels of steroids, expression of their receptors (AR, ESR1), and expression of genes from the insulin-like growth factor network (IGF1, IGF2, IGF1R, and IGF2R) in livers. Specifically, we measured gene expression before the onset of dimorphic growth, at the time when males have more active bone growth plates and sexual size dimorphism was clearly visible, and after a period of pronounced growth in both sexes. We found a significant spike in the expression of IGF1 in males around the time when dimorphism develops. This overexpression in males comes long after an increase in circulating testosterone levels and sexual maturation in males, and it might be suppressed by ovarian hormones in females. The results suggest that sexual size dimorphism in male-larger lizards can be caused by a positive effect of high levels of IGF1 on bone growth. The peak in IGF1 resembles the situation during the pubertal growth spurt in humans, but in lizards, it seems to be sex-specific and disconnected from sexual maturation.

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Section: Discussionmentioning

confidence: 99%

Development of male-larger sexual size dimorphism in a lizard: IGF1 peak long after sexual maturity overlaps with pronounced growth in males

Meter

Kratochvíl²,

Kubička³

et al. 2022

Front. Physiol.

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“…An important circulating compound that is responsive to nutritional limitation and could exert an influence on reproduction is insulin‐like growth factor‐1 (IGF‐1). IGF‐1 is a pleiotropic peptide hormone regulating growth, body size, sexual maturation, reproductive investment and lifespan across a broad range of species (Baker et al 1993, Holzenberger et al 2003, Van Heemst et al 2010, Dantzer and Swanson 2012, Lodjak et al 2018, Lendvai et al 2021, Lodjak and Verhulst 2020). Fasting or low dietary protein intake was shown to decrease plasma IGF‐1 concentrations in various species including dairy cattle Bos taurus (Zulu et al 2002), Steller sea lions Eumetopias jubatus (du Dot et al 2009), domestic fowl Gallus gallus domesticus (Lauterio and Scanes 1987) and great tits Parus major (Lodjak et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Food restriction delays breeding and affects insulin‐like growth factor‐1, oxidative damage and haematocrit value before egg‐laying in female canaries

Hargitai

Boross

Tóth

et al. 2022

Journal of Avian Biology

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Environmental challenges, such as fluctuations in food availability, could influence reproductive investment. If resource availability is poor, individuals need to decide in which life‐history process they invest more energy and vital compounds, which determine the cost of reproduction. In resource allocation, the physiological pathways have important roles. The aim of our study was to examine whether food availability influenced physiological traits (insulin‐like growth factor‐1 (IGF‐1) concentration, antioxidant capacity (OXY), level of oxidative damage (ROM) and haematocrit value) prior to egg‐laying in female canaries Serinus canaria. We also tested whether these physiological traits were associated with traits reflecting the reproductive investment in egg macro‐ (egg mass and yolk mass) and micronutrient content (eggshell biliverdin‐ and protoporphyrin‐based colouration). To test these questions we conducted a food restriction experiment with control and food‐restricted (72% of control food) groups. Our study showed that food‐restricted canary females delayed egg‐laying and the physiological traits differed between the groups. At the pre‐laying period, after 9–11 days of treatment, a reduction in plasma IGF‐1 concentration, ROM level and haematocrit value was detected in the control group, whereas in the food‐restricted group plasma IGF‐1 concentration increased, while ROM level and haematocrit value did not change. Plasma level of OXY was not influenced by treatment or breeding period. Plasma concentration of IGF‐1, haematocrit value and oxidative status before egg laying did not affect the egg characteristics. Our study highlights the importance of breeding stage when studying and interpreting the effects of food restriction on physiological traits of breeding birds. Moreover, our data suggest that nutritional limitation had an effect on the timing of egg‐laying that could be mediated by changes in physiological variables.

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“…Accordingly, hormonal pathways have been proposed to play a key role in regulating life-history trade-offs (Ricklefs and Wikelski, 2002). One candidate hormone is insulin-like growth factor 1 (IGF-1), which is an evolutionarily conserved polypeptide known to have effects on three key life-history traits: growth, reproduction, and survival (Swanson and Dantzer, 2014;Lodjak and Verhulst, 2020). Moreover, IGF-1 is suspected to be involved in the regulation of the trade-offs among these three life-history traits, but this hypothesis has only been scarcely tested in free-living animals (Swanson and Dantzer, 2014;Lodjak and Verhulst, 2020).…”

Section: Introductionmentioning

confidence: 99%

Does IGF-1 Shape Life-History Trade-Offs? Opposite Associations of IGF-1 With Telomere Length and Body Size in a Free-Living Bird

et al. 2022

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Hormonal pathways have been proposed to be key at modulating how fast individuals grow and reproduce and how long they live (i.e., life history trajectory). Research in model species living under controlled environment is suggesting that insulin-like growth factor 1 (IGF-1), which is an evolutionarily conserved polypeptide hormone, has an important role in modulating animal life histories. Much remains, however, to be done to test the role played by IGF-1 in shaping the phenotype and life history of animals in the wild. Using a wild long-lived bird, the Alpine swift (Tachymarptis melba), we show that adults with higher levels of IGF-1 had longer wings and shorter telomeres. Hence, telomeres being a proxy of lifespan in this species, our results support a potential role of IGF-1 at shaping the life-history of wild birds and suggest that IGF-1 may influence the growth-lifespan trade-off.

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Insulin-like growth factor 1 of wild vertebrates in a life-history context

Cited by 26 publications

References 181 publications

Development of male-larger sexual size dimorphism in a lizard: IGF1 peak long after sexual maturity overlaps with pronounced growth in males

Development of male-larger sexual size dimorphism in a lizard: IGF1 peak long after sexual maturity overlaps with pronounced growth in males

Food restriction delays breeding and affects insulin‐like growth factor‐1, oxidative damage and haematocrit value before egg‐laying in female canaries

Does IGF-1 Shape Life-History Trade-Offs? Opposite Associations of IGF-1 With Telomere Length and Body Size in a Free-Living Bird

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