Insulin-like growth factor 1 is required for survival of transit-amplifying neuroblasts and differentiation of otic neurons

Camarero, Guadalupe; León, Yolanda; Gorospe, Itziar; Pablo, Flora de; Alsina, Berta; Giráldez, Fernando; Varela-Nieto, Isabel

doi:10.1016/s0012-1606(03)00387-7

Cited by 60 publications

(74 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We have previously found elevated levels of IGF-1 mRNA expression in SVZ at 1 and 6 weeks after stroke, with progressive increase of percentage of microglia expressing IGF-1 protein between 2 and 16 weeks (Thored, et al, 2009). IGF-1 mitigates apoptosis and promotes proliferation and differentiation of neural stem cells (Camarero, et al, 2003, Kalluri, et al, 2007, Otaegi, et al, 2006. These findings raise the possibility that Mac-1+ microglia in SVZ support neurogenesis at a later stage after the insult, which would explain why such an effect was not detected by the early Mac-1-saporin lesion used here.…”

Section: Discussionmentioning

confidence: 61%

Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke

Heldmann

Mine

Kokaia

et al. 2011

Experimental Neurology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 61%

Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke

Heldmann

Mine

Kokaia

et al. 2011

Experimental Neurology

View full text Add to dashboard Cite

“…2C). Blockage of endogenous IGF-I activity inhibits CVG formation in growth factor-free medium and increases cell death, revealing that endogenous IGF-I activity is essential for ganglion generation and survival (Camarero et al, 2003). These studies suggest that proliferation, differentiation and survival of neural progenitors and neurons of the inner ear are dependent on IGF-I.…”

Section: The Insulin-like Growth Factor System In Inner Ear Neurogenesismentioning

confidence: 79%

“…IGF-I is also required for the early differentiation and survival of neuroblasts in the chicken otic vesicle (Table 1; Fig. 2B) (Camarero et al, 2003). IGF-I and IGF1R are expressed in the developing chicken otic epithelium and CVG (Camarero et al, 2003) and in the postnatal cochlear and vestibular ganglia (Camarero et al, 2001 and reviewed in Varela-Nieto et al, 2003 and.…”

Section: The Insulin-like Growth Factor System In Inner Ear Neurogenesismentioning

confidence: 96%

“…2B) (Camarero et al, 2003). IGF-I and IGF1R are expressed in the developing chicken otic epithelium and CVG (Camarero et al, 2003) and in the postnatal cochlear and vestibular ganglia (Camarero et al, 2001 and reviewed in Varela-Nieto et al, 2003 and. In organotypic cultures of chicken otic vesicles, the addition of exogenous IGF-I causes an increase in cell number in the otic vesicle and its associated CVG, mimicking the normal pattern of in vivo morphogenesis (Leon et al, 1995).…”

Section: The Insulin-like Growth Factor System In Inner Ear Neurogenesismentioning

confidence: 99%

See 1 more Smart Citation

A network of growth and transcription factors controls neuronal differentation and survival in the developing ear

Sánchez-Calderón¹,

Milo²,

León³

et al. 2007

Int. J. Dev. Biol.

View full text Add to dashboard Cite

Inner ear neurons develop from the otic placode and connect hair cells with central neurons in auditory brain stem nuclei. Otic neurogenesis is a developmental process which can be separated into different cellular states that are characterized by a distinct combination of molecular markers. Neurogenesis is highly regulated by a network of extrinsic and intrinsic factors, whose participation in auditory neurogenesis is discussed. Trophic factors include the fibroblast growth factor, neurotrophins and insulin-like peptide families. The expression domains of transcription factor families and their roles in the regulation of intracellular signaling pathways associated with neurogenesis are also discussed. Understanding and defining the key factors and gene networks in the development and function of the inner ear represents an important step towards defeating deafness. KEY WORDS: otic neurogenesis, IGF-I, FGF, inner ear, auditory ganglion, cochlear microarray Otic neurogenesisThe inner ear develops from the otic placode, an ectodermal patch located close to the neural tube that invaginates to form a transitory structure, the otic cup. This cup subsequently closes and pinches off from the ectoderm to generate the otic vesicle ( Figure 1). The otic vesicle is an autonomous structure that contains the information required to generate most of the cell types and structures of the adult inner ear (Bissonnette and Fekete, 1996;Bever et al., 2003; reviewed in Varela-Nieto et al., 2004). The mammalian inner ear is composed of six distinct sensory organs: the three cristae of the semicircular canal, the two maculae of the saccule and utricle and the organ of Corti in the cochlea. The cristae and the maculae are vestibular organs, whereas the organ of Corti is the organ of hearing (reviewed in Moller, 2006). The inner ear cochlear ganglion is formed by bipolar neurons that connect the peripheral sensory receptors or hair cells with central neurons in auditory brain stem nuclei. The correct organogenesis of the inner ear involves a dynamic balance of cell proliferation, differentiation, survival and death, processes that are tightly regulated by a network of extrinsic and intrinsic factors (Frago et al., 2000;Varela-Nieto et al., 2003 andLeon et al., 2004).The process of otic neurogenesis can be separated into different cellular states, each characterized by a distinct combination of molecular markers (summarized in Figure 1A). The first Int. J. Dev. Biol. 51: 557-570 (2007) doi: 10.1387/ijdb.072373hs visible output of otic neurogenesis is the delamination of neural cells (otic neuroblasts) from the otic cup (Fig. 1B). These neuroblasts are committed to generate otic neurons and they populate the cochleo-vestibular ganglion (CVG). This ganglion is generated from a region of the otic vesicle epithelium denominated the prospective neural-sensorial domain and that is defined by the domain in which Ngn1 and Deltal1 are co-expressed at early stages (Adam et al., 1998;Abu-Elmagd et al., 2001). It is believed that both n...

show abstract

“…IGF-1 has been shown to be critical for early differentiation and survival of otic neurons (Camarero et al, 2001(Camarero et al, , 2003. The response of target cells to IGF-I is mediated by its high affinity receptor, IGF1R, a transmembrane tyrosine kinase receptor.…”

Section: Neurons and Innervation: Connections And Survivalmentioning

confidence: 99%

The molecular biology of ear development - "Twenty years are nothing"

Giráldez

Fritzsch²

2007

Int. J. Dev. Biol.

View full text Add to dashboard Cite

Views of classical biological problems changed dramatically with the rise of molecular biology as a common framework. It was indeed the new language of life sciences. Molecular biology increasingly moved us towards a unified view of developmental genetics as ideas and techniques were imported to vertebrates from other biological systems where genetics was in a more advanced state. The ultimate advance has been the ability to actually perform genetic manipulations in vertebrate organisms that were almost unthinkable before. During the last two decades these technical advances entered into and affected the research on ear development. These events are still very recent and have been with us for no longer than two decades, which is the reason for the title of this article. This new scenario forms the basis of the current and productive work of many laboratories, and this is what this Special Issue of The International Journal of Developmental Biology wants to show, presenting a snapshot of insights at the beginning of the 21st Century. In this article, we give an overview of the topics that are addressed in this Ear Development Special Issue, and also we take the opportunity to informally dig into the genealogy of some of those topics, trying to link the current work with some classical work of the past. KEY WORDS: cell fate, patterning, hair cell, otic neuron, morphogenesis, evolution, regenerationEach time is characterised by the field of possibility that defines not only the standing theories or beliefs, but also the nature of the objects which are accessible to analysis, the means to look at them and the way to observe and to talk about them. (Jacob, 1976) There has been a sustained interest in ear developmental biology all throughout the 20 th century. As with many other fields in biology and neurosciences, this interest is in part rooted in curiosity and in part is driven by the intent to understand and cure diseases. There is an immense catalogue of histological observations and clever experimental manipulations of the embryonic ear that have contributed to an increase in our knowledge of the development of the ear and that was able to paint a picture of ear development by the end of the eighties (see Rubel, 1978; and the report of the Holte Symposium (Cremers et al., 1987). The view at the end of the eighties, however detailed, remained descriptive and phenomenological: the gap between cells, genes and proteins was Int. J. Dev. Biol. 51: 429-438 (2007) still too large and many processes were unknown leaving "the widest gap to be filled… to understanding how cells with identical genomes may become differentiated" (Jacob, 1947). Thirty years elapsed from the publishing of the double helix in 1953 to the polymerase chain reaction (Saiki et al., 1985) and during this period of time the whole of biology was changed and set a new paradigm. Views of classical biological problems, changed dramatically with the rise of molecular biology as a common framework. It was indeed the new language of life scien...

show abstract

Insulin-like growth factor 1 is required for survival of transit-amplifying neuroblasts and differentiation of otic neurons

Cited by 60 publications

References 52 publications

Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke

Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke

A network of growth and transcription factors controls neuronal differentation and survival in the developing ear

The molecular biology of ear development - "Twenty years are nothing"

Contact Info

Product

Resources

About