Insulin-Like Growth Factor-1 (Igf-1): Relation With Cognitive Functioning and Neuroimaging Marker of Brain Damage in a Sample of Hypertensive Elderly Subjects

Association of insulin-like growth factor-1 with mild cognitive impairment and slow gait speed

“…IGF-I receptors are widely expressed not only in the brain, specifically in the hippocampus and parahippocampal areas, olfactory bulb, and cerebellar cortex, but also in the amygdala, prefrontal cortex, and hypothalamus and dorsal thalamic nuclei (Adem et al, 1989;Bondy and Cheng, 2004). Studies regarding multipledomain neuropsychological assessments also tend to have been conducted in relatively small cohorts and have produced some conflicting results (Aleman and Torres-Aleman, 2009;Angelini et al, 2009;Arwert et al, 2005). Our findings from a populationbased survey with a large sample size may help to clarify these previous results.…”

“…Regarding specific cognitive domains, there are conflicting results on the association with IGF-1. Lower IGF-1 has been associated with orientation, memory, praxis, and frontal functions (Angelini et al, 2009), whereas Dik et al (2003) found that a reduced level of IGF-1 is predictive for a decline in the processing speed alone. These results were discussed in the context of the sensitivity of neuropsychological measures against biological factors (Dik et al, 2003).…”

Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging

“…1-3), mimicking the aging phenotype. Importantly, the available human evidence suggest that hypertension in IGF-1 deficient patients also significantly compromise higher brain function (Angelini et al 2009). Early studies on decreased capillary density in the peripheral circulation of hypertensive experimental animals and human patients proposed that rarefaction can be either structural (capillary attrition) or functional, associated with impaired recruitment of nonperfused capillaries (Chen et al 1981;Hashimoto et al 1987;Ono et al 1989;Prewitt et al 1986;Prewitt et al 1982;Prewitt et al 1984;Stacy and Prewitt 1989;Sullivan et al 1983).…”

“…Recent evidence shows that old age exacerbates hypertension-induced cerebromicrovascular rarefaction (Toth et al 2013a). Further, low circulating IGF-1 levels increase the risk for hypertension-induced microvascular brain damage in elderly patients (Angelini et al 2009), findings which have been also replicated in laboratory animals (Toth et al 2014a). Despite these advances, the synergistic/additive effects of circulating IGF-1 deficiency and hypertension on cerebral microvascular density have not been explored.…”

Blood biomarkers to identify ischemic stroke etiologies

“…Increased serum levels in patients with impaired vasodilation [81] IGF-1 Protein P01343 Low levels of this hormone (<79.4 µg/l) are associated with cognitive decline in hypertensive elderly subjects [82] MMP-9…”