Insulin-like factor binding protein-3 promotes the G1 cell cycle arrest in several cancer cell lines

Wu, Chen; Liu, Xiaobo; Wang, Yuanyuan; Tian, Haijun; Xie, Yi; Li, Qinjian; Zhang, Xiaokang; Liu, Fangming

doi:10.1016/j.gene.2012.09.080

Cited by 20 publications

(16 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IGFBP-3 induces G1 cell cycle arrest and apoptosis in several cancer cell lines, including human NSCLC [44]. The alteration of this protein by oncogenic Akt can be considered as a new cancer therapeutic target.…”

Section: New Advances In Metabolism and Cancer---glycolytic Factormentioning

confidence: 99%

Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases

Cao

Wang

2017

Aging and disease

View full text Add to dashboard Cite

Accumulating epidemiological studies have implicated a strong link between age associated metabolic diseases and cancer, though direct and irrefutable evidence is missing. In this review, we discuss the connection between Warburg effects and tumorigenesis, as well as adaptive responses to environment such as circadian rhythms on molecular pathways involved in metabolism. We also review the central role of the sirtuin family of proteins in physiological modulation of cellular processes and age-associated metabolic diseases. We also provide a macroscopic view of how the circadian rhythm affects metabolism and may be involved in cell metabolism reprogramming and cancer pathogenesis. The aberrations in metabolism and the circadian system may lead to age-associated diseases directly or through intermediates. These intermediates may be either mutated or reprogrammed, thus becoming responsible for chromatin modification and oncogene transcription. Integration of circadian rhythm and metabolic reprogramming in the holistic understanding of metabolic diseases and cancer may provide additional insights into human diseases.

show abstract

Section: New Advances In Metabolism and Cancer---glycolytic Factormentioning

confidence: 99%

Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases

Cao

Wang

2017

Aging and disease

View full text Add to dashboard Cite

show abstract

“…So, the aberrant increase of NNMT in GSCs may also be associated with GSCs development. In addition, the insulin-like factor binding protein-3 (IGFBP3), which was found noticeably increased in GSCs, has been reported to be a multi-functional protein that is known to induce apoptosis of various cancer cells by the activation of caspases and the induction of cell cycle arrest [Wu et al, 2013]. In this study, such factor as sex should not be considered because both human GSCs and human NSCs were derived from male patients, so, the deletion or decrease of Sox1 in GSCs may contribute to the malignant transition of NSCs to GSCs.…”

Section: Discussionmentioning

confidence: 99%

Regulatory Roles of miRNA in the Human Neural Stem Cell Transformation to Glioma Stem Cells

Liu

Yin

Zhang

et al. 2014

J of Cellular Biochemistry

View full text Add to dashboard Cite

To investigate the expressional alternation of microRNAs (miRNA) during the malignant transformation and development of human glioma, we measured miRNA expression profile as well as mRNA expression profile in normal human neural stem cells (hNSCs) and human glioma stem cells (hGSCs). We found 116 miRNA up-regulated and 62 miRNA down-regulated in GSCs. On the other hand, we identified 1,372 mRNA down-regulated, and 1,501 mRNA up-regulated in GSCs compared to those in NSCs. We then analyzed the pathways and the predicted target genes of the miRNAs which differ significantly in expression between GSCs and NSCs using the statistical enrichment methods. These target mRNAs are involved in many cancer-related signaling pathways, such as cell cycle, axon guidance, glioma development, adhesion junction, MAPK and Wnt signaling. Furthermore, we obtained the differently expressed miRNA-target relationships according to the θ value which is used to calculate the regulation extent of miRNA-target and using the databases of miRanda, Targetscans and Pictar. Among the top 10 miRNA-target relationships, hsa-miR-198 and its potential targeted gene DCX and NNAT were selected for validation, and NNAT was found to be the direct target of miR-198. Finally, the functional roles of miR-155-5p and miR-124-3p whose expressions altered significantly between GSCs and NSCs were addressed. Our results provide new clues for the potential mechanisms involved in the origin and development of glioma. Clinically, the altered miRNAs may serve as potential targets and diagnostic tools for novel therapeutic strategies of glioblastoma.

show abstract

“…Activation of MYC was previously identified as a signature of cancer proliferation (42) and a key regulatory feature of basal-like cancers (5). Several of the p53 and MYC-regulated phosphoproteins with sites specific for basal tumor type were also linked to the EGF/EGFR (ErbB-1) and TGFβ1 signaling pathways, including phosphoproteins IBP3 (43), FSTL3 (44), and STC2 (41, 45), all of which were subsequently found to have basal-specific phosphosites qualified in plasma. Several phosphoproteins with luminal-specific phosphosites were also identified, and involved the AKT and estrogen mediated signaling pathways, including a HIFα1-regulated oncogene HER2 (ErbB2).…”

Section: Discussionmentioning

confidence: 99%

Phosphoprotein Secretome of Tumor Cells as a Source of Candidates for Breast Cancer Biomarkers in Plasma

Zawadzka

Schilling

Cusack

et al. 2014

Molecular & Cellular Proteomics

View full text Add to dashboard Cite

Breast cancer is a heterogeneous disease whose molecular diversity is not well reflected in clinical and pathological markers used for prognosis and treatment selection. As tumor cells secrete proteins into the extracellular environment, some of these proteins reach circulation and could become suitable biomarkers for improving diagnosis or monitoring response to treatment. As many signaling pathways and interaction networks are altered in cancerous tissues by protein phosphorylation, changes in the secretory phosphoproteome of cancer tissues could reflect both disease progression and subtype. To test this hypothesis, we compared the phosphopeptide-enriched fractions obtained from proteins secreted into conditioned media (CM) derived from five luminal and five basal type breast cancer cell lines using label-free quantitative mass spectrometry. Altogether over 5000 phosphosites derived from 1756 phosphoproteins were identified, several of which have the potential to qualify as phosphopeptide plasma biomarker candidates for the more aggressive basal and also the luminal-type breast cancers. The analysis of phosphopeptides from breast cancer patient plasma and controls allowed us to construct a discovery list of phosphosites under rigorous collection conditions, and second to qualify discovery candidates generated from the CM studies. Indeed, a set of basal-specific phosphorylation CM site candidates derived from IBP3, CD44, OPN, FSTL3, LAMB1, and STC2, and luminal-specific candidates derived from CYTC and IBP5 were selected and, based on their presence in plasma, quantified across all cell line CM samples using Skyline MS1 intensity data. Together, this approach allowed us to assemble a set of novel cancer subtype specific phosphopeptide candidates for subsequent biomarker verification and clinical validation.

show abstract

Insulin-like factor binding protein-3 promotes the G1 cell cycle arrest in several cancer cell lines

Cited by 20 publications

References 40 publications

Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases

Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases

Regulatory Roles of miRNA in the Human Neural Stem Cell Transformation to Glioma Stem Cells

Phosphoprotein Secretome of Tumor Cells as a Source of Candidates for Breast Cancer Biomarkers in Plasma

Contact Info

Product

Resources

About