Insulin‐like effect of some polyamines on lipoprotein lipase from rat adipose tissue

Giudicelli, Yves; Rebourcet, Marie-Christine; Nordmann, Roger; Nordmann, J

doi:10.1016/0014-5793(76)80019-1

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…One possibility is that a high plasma glucose level may induce a protective feedback mechanism of polyamines, thus resulting in the elevation of polyamine concentrations to inhibit glycation. Another possibility, based on experimental evidence showing the insulin-like effect of polyamines on lipoprotein lipase activity or glucose metabolism, is that a higher concentration of circulating polyamines may result in a lower glucose [17,18]. To our knowledge, however, no research has been carried out on humans to date that confirms these twofold speculations.…”

Section: Introductionmentioning

confidence: 63%

Association of glycemic profiles with whole blood polyamine among middle-aged Japanese men: colorimetric assay using oat and barley seedling polyamine oxidase

Kondo

Yamamoto

Kimata

et al. 2007

Environ Health Prev Med

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Objectives Polyamines have long been known to have an insulin-like action, but their antiglycating effect has only recently attracted the attention of researchers. The aim of our investigation was to determine the whole blood polyamine concentration in a healthy population in order to examine its relationship with glycemic profiles. Methods The study cohort comprised 622 men aged 40-59 who participated in a health checkup program conducted in 1997, when they underwent measurements of fasting plasma glucose (FPG), insulin (FPI), and fructosamine as glycemic indices. Colorimetric assay methods using oat and barley seedling polyamine oxidase were used to determine total polyamine (spermidine + spermine) and spermine concentrations in the whole blood, respectively. Polyamine concentrations adjusted for hemoglobin were quartiled for the analysis of covariance to assess the association with glycemic indices. Results A significant association was demonstrated between the FPG and total polyamine concentrations. In the trend test, FPG and fructosamine levels increased in accordance with the shift of quartiles of total polyamine concentrations from low to high. In contrast, the association between the spermine and glycemic indices was not statistically significant based on the test for difference of multivariate-adjusted means or trend for linearity. Conclusions This is the first epidemiological study to reveal that the concentrations of blood polyamines are related with either FPG or fructosamine level in a healthy population. There may be some feedback mechanism for the elevation of circulating polyamines to quench the glycation reaction under hyperglycemic conditions. In addition, total polyamines, rather than spermine alone, seem to be a sensitive biomarker representing the antiglycation effect of polyamines.

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Section: Introductionmentioning

confidence: 63%

Association of glycemic profiles with whole blood polyamine among middle-aged Japanese men: colorimetric assay using oat and barley seedling polyamine oxidase

Kondo

Yamamoto

Kimata

et al. 2007

Environ Health Prev Med

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“…first showed that the addition of spermine to cultured adipocytes could increase glucose intake [6]. A few years later, spermine and spermidine were demonstrated to significantly enhance lipoprotein lipase activity and favour fatty acid uptake [7]. During the late 70s and the early 80s, Jamdar et al.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo efficacy of sulfo‐carrabiose, a sugar‐based cosmetic ingredient with anti‐cellulite properties

Vogelgesang¹,

Bonnet²,

Godard³

et al. 2010

Intern J of Cosmetic Sci

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Most of adult women exhibit cellulite on the hips, buttock and thighs. Although extracellular matrix and lymphatic system disorders can increase its appearance, cellulite basically results from an excessive fat storage in the adipose tissue which exerts considerable pressure on the surrounding skin tissue and creates a dimpled irregular appearance. Caffeine, the most widely used anti-cellulite ingredient, favours fat break-down by inhibiting the phosphodiesterase enzyme and encouraging a high intracellular level of cAMP. A series of studies has shown that spermine and spermidine, two ubiquitous polyamines, encouraged fat storage and slowed fat break-down in the adipose tissue. Besides, it was shown that heparan sulfate glycosaminoglycans had a strong affinity for polyamines. To design a new cosmetic ingredient with anti-cellulite properties, we used molecular modelling to screen several ingredients with a structure similar to that of heparan sulfate glycosaminoglycans. This way, we identified sulfo-carrabiose as a potent molecule for trapping spermine and spermidine. These virtual results were first confirmed in tubo where sulfo-carrabiose was shown to dose-dependently inactivate spermine and spermidine. In vitro, adipocytes cultured with sulfo-carrabiose exhibited a significant reduction of lipogenesis and a significant increase of lipolysis. When sulfo-carrabiose was incorporated in a cosmetic formula, significant improvements were observed in thigh circumference, with better results than those obtained with caffeine after 28 days of use. Furthermore, a combination of caffeine and sulfo-carrabiose led to results significantly better than those obtained with caffeine alone. As measured by fringe projection, thigh volume was also significantly reduced after sulfo-carrabiose treatment. Finally, the appearance of cellulite assessed by clinical evaluation was also significantly reduced within 28 days.

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Glycerolipid biosynthesis in rat adipose tissue effect of polyamines on triglyceride synthesis

Jamdar

1977

Archives of Biochemistry and Biophysics

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Insulin‐like effect of some polyamines on lipoprotein lipase from rat adipose tissue

Cited by 8 publications

References 11 publications

Association of glycemic profiles with whole blood polyamine among middle-aged Japanese men: colorimetric assay using oat and barley seedling polyamine oxidase

Association of glycemic profiles with whole blood polyamine among middle-aged Japanese men: colorimetric assay using oat and barley seedling polyamine oxidase

In vitro and in vivo efficacy of sulfo‐carrabiose, a sugar‐based cosmetic ingredient with anti‐cellulite properties

Glycerolipid biosynthesis in rat adipose tissue effect of polyamines on triglyceride synthesis

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