Insulin levels in insulin resistance: phantom of the metabolic opera?

Samaras, Katherine; Welborn, T.; McElduff, Aidan; Proietto, Joseph; Twigg, Stephen M.; Zimmet, Paul; Campbell, Lesley V.

doi:10.5694/j.1326-5377.2007.tb00895.x

Cited by 14 publications

(18 citation statements)

References 2 publications

(1 reference statement)

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“…21 The results presented indicate a strong correlation between fasting insulin and ISI derived from an OGTT and insulin resistance (HOMA). 21 The results presented indicate a strong correlation between fasting insulin and ISI derived from an OGTT and insulin resistance (HOMA).…”

Section: Discussionmentioning

confidence: 76%

Evaluation of glycaemic status in young people with clinical insulin resistance; fasting glucose, fasting insulin or an oral glucose tolerance test?

Garnett

Srinivasan

Birt

et al. 2010

Clinical Endocrinology

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Section: Discussionmentioning

confidence: 76%

Evaluation of glycaemic status in young people with clinical insulin resistance; fasting glucose, fasting insulin or an oral glucose tolerance test?

Garnett

Srinivasan

Birt

et al. 2010

Clinical Endocrinology

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“…Insulin levels are less suited to yield a diagnosis in the single patient than to study metabolic tendencies in groups 38,39. Intact proinsulin has been shown to be a highly specific indirect marker for insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Investigation of insulin resistance in narcoleptic patients: dependent or independent of body mass index?

Engel

Helfrich²,

Manderscheid³

et al. 2011

NDT

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Background:Narcolepsy is a severe sleep-wake cycle disorder resulting in most cases from a lack of orexin, the energy balance-regulating hormone. Narcoleptic patients have been reported to suffer from an excess morbidity of Type 2 diabetes, even after correction for their often elevated body mass index.Methods:To explore whether narcolepsy is specifically associated with a propensity to develop insulin resistance, we measured fasting glucose, insulin, and intact proinsulin levels in 43 narcoleptic patients and 47 controls matched for body mass index and age. The proinsulin-to-insulin ratio was calculated. Insulin resistance was determined using the homeostatic model assessment method.Results:Narcoleptic patients did not show elevated insulin resistance parameters.Conclusion:In contrast with earlier reports, we found no evidence that narcolepsy specifically elevates the risk of insulin resistance (and consequently of type 2 diabetes) independently of body mass index.

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“…To the Editor : We read with interest the recent article on insulin resistance, 1 and we strongly support the argument that there is no current clinical utility to measuring fasting insulin levels. However, we are concerned about the statement that “otherwise well patients whom we see in practice are demanding (and receiving) metformin, or are being told they need it, particularly for polycystic ovary syndrome” (PCOS).…”

mentioning

confidence: 78%

Insulin levels, insulin resistance and the use of metformin in polycystic ovary syndrome

Hutchison

Zoungas

Teede

2007

Medical Journal of Australia

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Insulin levels in insulin resistance: phantom of the metabolic opera?

Cited by 14 publications

References 2 publications

Evaluation of glycaemic status in young people with clinical insulin resistance; fasting glucose, fasting insulin or an oral glucose tolerance test?

Evaluation of glycaemic status in young people with clinical insulin resistance; fasting glucose, fasting insulin or an oral glucose tolerance test?

Investigation of insulin resistance in narcoleptic patients: dependent or independent of body mass index?

Insulin levels, insulin resistance and the use of metformin in polycystic ovary syndrome

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