Insulin levels during fasting and the glucose tolerance test and Homaʼs index predict subsequent development of hypertension

Kashiwabara, Hideyuki; Inaba, Masaaki; Maruno, Yoshiko; Morita, Toshisuke; Awata, Takuya; Negishi, Kiyohiko; Iitaka, Makoto; Katayama, Shigehiro

doi:10.1097/00004872-200018010-00012

Cited by 40 publications

(44 citation statements)

References 17 publications

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“…27 Indeed, previous data suggest that individuals with both hypertension and type II diabetes have higher IR than normotensive type II diabetic patients. 28,29 Our main finding was that HOMA-IR, 1/HOMA-IR and QUICKI indices were strongly and significantly correlated with all the indices derived from clamp technique in this population. These results further prove the validity of these measures to assess IS.…”

Section: Discussionmentioning

confidence: 67%

“…7,8 Patients with both hypertension and type II diabetes are more insulin-resistant that those with only type II diabetes. 28,29 K Several studies in a variety of populations have shown that indices like HOMA-IR or QUICKI are valid surrogate markers for insulin sensitivity. [13][14][15][16][17][18][19][20] K Data on the reliability of the above indices, 13,19,22 as well as their validity in hypertensive populations 11,13,19,22 are very limited.…”

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confidence: 99%

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Validity and reproducibility of HOMA-IR, 1/HOMA-IR, QUICKI and McAuley's indices in patients with hypertension and type II diabetes

et al. 2007

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The aim of this study was to evaluate the validity and reliability of homeostasis model assessment-insulin resistance (HOMA-IR) index, its reciprocal (1/HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and McAuley's index in hypertensive diabetic patients. In 78 patients with hypertension and type II diabetes glucose, insulin and triglyceride levels were determined after a 12-h fast to calculate these indices, and insulin sensitivity (IS) was measured with the hyperinsulinemic euglycemic clamp technique. Two weeks later, subjects had again their glucose, insulin and triglycerides measured. Simple and multiple linear regression analysis were applied to assess the validity of these indices compared to clamp IS and coefficients of variation between the two visits were estimated to assess their reproducibility. HOMA-IR index was strongly and inversely correlated with the basic IS clamp index, the Mvalue (r ¼ À0.572, Po0.001), M-value normalized with subjects' body weight or fat-free mass and every other clamp-derived index. 1/HOMA-IR and QUICKI indices were positively correlated with the M-value (r ¼ 0.342, Po0.05 and r ¼ 0.456, Po0.01, respectively) and the rest clamp indices. McAuley's index generally presented less strong correlations (r ¼ 0.317, Po0.05 with M-value). In multivariate analysis, HOMA-IR was the best fit of clampderived IS. Coefficients of variation between the two visits were 23.5% for HOMA-IR, 19.2% for 1/HOMA-IR, 7.8% for QUICKI and 15.1% for McAuley's index. In conclusion, HOMA-IR, 1/HOMA-IR and QUICKI are valid estimates of clamp-derived IS in patients with hypertension and type II diabetes, whereas the validity of McAuley's index needs further evaluation. QUICKI displayed better reproducibility than the other indices.

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Section: Discussionmentioning

confidence: 67%

mentioning

confidence: 99%

Validity and reproducibility of HOMA-IR, 1/HOMA-IR, QUICKI and McAuley's indices in patients with hypertension and type II diabetes

et al. 2007

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“…Furthermore, the mean systolic blood pressure was in the upper range of normal, and the mean diastolic blood pressure was in the borderline hypertensive range. The mean value of the HOMA index (Japan Diabetes Society, 2002), which is a marker of insulin resistance, was 43.0 and the proportion of subjects with HOMA index 42.5 was 71% in both groups, indicating that the majority of the subjects had insulin resistance (Kashiwabara et al, 2000;Japan Diabetes Society, 2002;Mclaughlin et al, 2003;McNeely et al, 2003). The reason for the significant change appeared only in hemoglobin A1c was probably the stability for this measure, representing the average levels of serum glucose during the past 90 days.…”

Section: Discussionmentioning

confidence: 99%

Randomized controlled trial for an effect of green tea-extract powder supplementation on glucose abnormalities

et al. 2007

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Objective: We examined whether green tea-extract powder supplementation improves glucose abnormality. Methods: The study was conducted for volunteers who resided in eastern communities of Shizuoka Prefecture and who had fasting blood glucose levels of X6.1 mmol/l or nonfasting blood glucose levels of X7.8 mmol/l in a recent health check-up. Sixty subjects aged 32-73 years (49 males and 11 females) participated in the trial. The Early intervention group consumed a packet of green tea-extract powder containing 544 mg polyphenols (456 mg catechins) daily for the first 2 months and then entered the 2-month nonintervention period. The Later intervention group was observed for the first 2 months and then consumed green tea-extract powder as described above for the subsequent 2 months. Using the two-period crossover design, we analyzed the changes in fasting hemoglobin A1c level and other biomarkers in blood samples collected at baseline, 2 months and 4 months. Results: A significant reduction in hemoglobin A1c level and a borderline significant reduction in diastolic blood pressure were associated with the intervention. The intervention caused no significant changes in weight, body mass index, body fat, systolic blood pressure, fasting serum glucose level, homeostasis model assessment index, serum lipid level or hypersensitive C-reactive protein.Conclusion: Daily supplementary intake of green tea-extract powder lowered the hemoglobin A1c level in individuals with borderline diabetes.

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“…25 It has been shown in previous studies that the insulinogenic index, which may reflect the early response of insulin secretion to glucose loading, declined as the glucose tolerance changed from normal to a diabetic pattern. 16,17 In normotensive acromegalic patients we observed a marginally significant higher insulinogenic index than in hypertensive acromegalics. This suggests that in hypertensive acromegalics glucose tolerance deteriorates from a normal to a diabetic pattern.…”

Section: Discussionmentioning

confidence: 67%

“…The mean plasma fasting glucose and insulin, insulinogenic index (ratio of the increment of the insulin level to that of glucose level between 0 and 30 min after the OGTT) and ⌺IRI (the sum of the plasma insulin levels 0, 30, 60 and 120 min after the OGTT) of both groups were compared. In addition, the homeostasis model insulin resistance index (Homa's index) 15 a candidate for the simple assessment of insulin sensitivity, 16,17 was calculated using the formula: fasting plasma glucose (mg/dl) × fasting insulinaemia ( U/ml) Ϭ 405, and the mean indices of the groups were compared.…”

Section: Methodsmentioning

confidence: 99%

Altered circadian blood pressure profile in patients with active acromegaly. Relationship with left ventricular mass and hormonal values

Pietrobelli¹,

Akopian²,

Olivieri³

et al. 2001

J Hum Hypertens

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To determine the relationships between the circadian blood pressure profile and left ventricular mass, hormonal pattern and insulin sensitivity indices in patients with active acromegaly, ambulatory 24-h blood pressure monitoring (ABPM) was recorded in 25 subjects (47.0 ؎ 15.1 years, range 23-72). Serum growth hormone (GH) and insulin-like growth factor-1, fasting and mean plasma glucose and insulin during oral glucose tolerance test (OGTT), insulinogenic index, the sum of the plasma insulin levels and the homeostasis model insulin resistance index (Homa's index) were determined. Left ventricular mass index (LVMI) was calculated from two-dimensional guided M-mode echocardiogram. The prevalence of hypertension was 56% (n ‫؍‬ 14) and 40% (n ‫؍‬ 10) according to sphygmomanometric measurements and ABPM, respectively. Non-dipping profile was observed in six of 10 hypertensives and in

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Insulin levels during fasting and the glucose tolerance test and Homaʼs index predict subsequent development of hypertension

Abstract: These results suggest that higher plasma IRI levels and/or insulin resistance are closely related to the pathogenesis of hypertension in patients with diabetes mellitus. Homa's index, fasting and sigmaIRI may be useful predictors of the subsequent development of hypertension.

Cited by 40 publications

References 17 publications

Validity and reproducibility of HOMA-IR, 1/HOMA-IR, QUICKI and McAuley's indices in patients with hypertension and type II diabetes

Validity and reproducibility of HOMA-IR, 1/HOMA-IR, QUICKI and McAuley's indices in patients with hypertension and type II diabetes

Randomized controlled trial for an effect of green tea-extract powder supplementation on glucose abnormalities

Altered circadian blood pressure profile in patients with active acromegaly. Relationship with left ventricular mass and hormonal values

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