Insulin Instability in Parenteral Nutrition Admixtures

Forchielli, Maria Luisa; Bongiovanni, F; Platé, L.; Piazza, Giulia; Puggioli, C.; D'Alise, Antonietta; Bersani, G.

doi:10.1002/jpen.1024

Cited by 16 publications

(12 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to a majority consensus vote, 8 papers from the primary literature collective were identified as the most important for pharmacy nutrition support practice. [6][7][8][9][10][11][12][13] An additional 13 articles comprising organizational guidelines, consensus, recommendation, and position papers included separately as important papers to our practice. [14][15][16][17][18][19][20][21][22][23][24][25][26] Of these 21 finalist publications, 5 were published in Journal of Parenteral and Enteral Nutrition,4 in Clinical Nutrition, 3 in Anesthesia & Analgesia, 2 in Nutrition in Clinical Practice, and 2 in New England Journal of Medicine.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Significant Published Articles for Pharmacy Nutrition Support Practice in 2018

et al. 2019

View full text Add to dashboard Cite

Purpose: The purpose of this article is to assist the pharmacist engaged in nutrition support therapy in staying current with pertinent literature. Methods: Several clinical pharmacists engaged in nutrition support therapy compiled a list of articles published in 2018 considered important to their clinical practice. The citation list was compiled into a single spreadsheet where the author participants were asked to assess whether the article was considered important to nutrition support pharmacy practice. A culled list of publications was then identified whereby the majority of author participants (at least 5 of 8) considered the paper to be important. Guideline and consensus papers from professional organizations, important to practice but not scored, were also included. Results: A total of 117 articles were identified; 8 from the primary literature were voted by the group to be of high importance. An additional 13 organizational guidelines, position, recommendation, or consensus papers were also identified. The top-ranked articles from the primary literature were reviewed. Conclusion: We recommend that pharmacists engaged in nutrition support therapy be familiar with these articles as it pertains to their practice.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Chapman et al 11 Energy-dense versus routine enteral nutrition in the critically ill 5 Forchielli et al 12 Insulin instability in parenteral nutrition admixtures 5 Peterson et al 13 Early exposure to recommended calorie delivery in the intensive care unit is associated with increased mortality in patients with acute respiratory distress syndrome 5…”

mentioning

confidence: 99%

Significant Published Articles for Pharmacy Nutrition Support Practice in 2018

et al. 2019

View full text Add to dashboard Cite

show abstract

“…However, the need for strict aseptic conditions may render the procedure impractical or not permissible. Furthermore, reservations exist regarding the diminished or highly variable efficacy of PN insulin due to interference from PN ingredients or bag surface material [54,55].…”

Section: Discussionmentioning

confidence: 99%

Management of Glucose Control in Noncritically Ill, Hospitalized Patients Receiving Parenteral and/or Enteral Nutrition: A Systematic Review

Laesser

Cumming

Reber

et al. 2019

JCM

View full text Add to dashboard Cite

Hyperglycemia is a common occurrence in hospitalized patients receiving parenteral and/or enteral nutrition. Although there are several approaches to manage hyperglycemia, there is no consensus on the best practice. We systematically searched PubMed, Embase, Cochrane Central, and ClinicalTrials.gov to identify records (published or registered between April 1999 and April 2019) investigating strategies to manage glucose control in adults receiving parenteral and/or enteral nutrition whilst hospitalized in noncritical care units. A total of 15 completed studies comprising 1170 patients were identified, of which 11 were clinical trials and four observational studies. Diabetes management strategies entailed adaptations of nutritional regimens in four studies, while the remainder assessed different insulin regimens and administration routes. Diabetes-specific nutritional regimens that reduced glycemic excursions, as well as algorithm-driven insulin delivery approaches that allowed for flexible glucose-responsive insulin dosing, were both effective in improving glycemic control. However, the assessed studies were, in general, of limited quality, and we see a clear need for future rigorous studies to establish standards of care for patients with hyperglycemia receiving nutrition support.

show abstract

“…Se ha descrito que la adsorción de insulina en las bolsas de NP abarca un amplio rango, del 44 % al 95 % (6). Esta diferencia de adsorción puede deberse a múltiples factores, como la composición de la NP, el tiempo de contacto de la insulina con los materiales, la concentración de insulina y la temperatura (7)(8)(9)(10).…”

unclassified