Insulin Infusion Improves Neutrophil Function in Diabetic Cardiac Surgery Patients

Rassias, Athos J.; Marrin, Charles A.S.; Arruda, Janice; Whalen, Patricia Kate; Beach, M. Miles; Yeager, Mark P.

doi:10.1097/00000539-199905000-00008

Cited by 131 publications

(66 citation statements)

References 22 publications

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“…30,[55][56][57][58] Generation of free radicals is reportedly as an important organismal defense mechanism during infectious processes. 30,51,59,60 In this work, it was found that both MEs of Brazil Nut oil increased the release of superoxides from human blood phagocytes.…”

Section: Figure 2 Pseudoternary Diagrams Indicating Microemulsion (1mentioning

confidence: 99%

Microemulsion of Brazil nut oil as a natural product to improve superoxide release in human phagocytes

et al. 2017

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The aim of this study was to develop and characterize a Brazil nut oil microemulsion system and determine the effect of this microemulsion on the superoxide release in human phagocytes. The microemulsion was formulated using distilled water, Brazil nut as the oily phase, Sorbitan monooleate, Polysorbate 80, and butan-1-ol. Hydrophile-lipophile balance of Brazil nut oil was determined, pseudoternary diagrams were prepared, and microemulsion diagram regions were preselected. Preliminary and accelerated stability tests, rheological characterization and dynamic light scattering were performed. The immunomodulatory effect of the microemulsion on the interactions with leukocytes was determined by superoxide release. The developed formulations were classified as oil-in-water, showed a Newtonian profile, with linear viscosity and droplet sizes of 46.9; 66.5 and 34.3 nm. When we assessed the interaction of the microemulsion of Brazil nut oil with phagocytes, we observed an increase in superoxide release. Our findings indicate that the developed formulation improved the immunomodulatory activity of the Brazil nut oil, proving to be a natural product option for future applications, in particular for infectious diseases.

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Section: Figure 2 Pseudoternary Diagrams Indicating Microemulsion (1mentioning

confidence: 99%

Microemulsion of Brazil nut oil as a natural product to improve superoxide release in human phagocytes

et al. 2017

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“…Continuous insulin infusion might improve the impaired neutrophil function observed in DM. 53,54 During the peritransplant period, enormous stress/inflammation or corticosteroids can induce insulin resistance, which leads to hyperglycemia owing to an insufficient insulin secretion to overcome such insulin resistance. CNI also decreases the secretion of insulin by pancreatic β cells.…”

Section: Ptdm and Clinical Outcomesmentioning

confidence: 99%

How do I manage hyperglycemia/post-transplant diabetes mellitus after allogeneic HSCT

Fuji

Rovó

Ohashi

et al. 2016

Bone Marrow Transplant

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Allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients frequently develop glucose intolerance and post-transplant diabetes mellitus (PTDM). The clinical importance of PTDM and its detrimental impact on HSCT outcomes are underrecognized. After allo-HSCT, various mechanisms can contribute to the development of PTDM. Here we review information about hyperglycemia and PTDM after allo-HSCT as well as PTDM after solid organ transplantation and describe ways to manage hyperglycemia/PTDM after allogeneic HSCT. Taking into consideration a lack of well-established evidence in the field of allo-HSCT, more studies should be conducted in the future, which will require closer multidisciplinary collaboration between hematologists, endocrinologists and nutritionists.

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“…The reduction in infectious diseases by IGC may reflect the deleterious effects of hyperglycemia on macrophage or neutrophil function or insulin-induced protective effects on mucosal and skin barriers. [24][25][26][27] The improvement of innate immunity could be quite important, especially during the period of granulocytopenia after allogeneic HSCT. The protection of mucosal tissues could reduce bacterial translocation, which might lead to a reduced incidence of sepsis.…”

Section: Intensive Glucose Control After Hsct S Fuji Et Almentioning

confidence: 99%

Intensive glucose control after allogeneic hematopoietic stem cell transplantation: a retrospective matched-cohort study

Fuji¹,

Kim

Mori

et al. 2009

Bone Marrow Transplant

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Insulin Infusion Improves Neutrophil Function in Diabetic Cardiac Surgery Patients

Abstract: A continuous insulin infusion and glucose control during surgery improves white cell function in diabetic patients and may increase resistance to infection after surgery.

Cited by 131 publications

References 22 publications

Microemulsion of Brazil nut oil as a natural product to improve superoxide release in human phagocytes

Microemulsion of Brazil nut oil as a natural product to improve superoxide release in human phagocytes

How do I manage hyperglycemia/post-transplant diabetes mellitus after allogeneic HSCT

Intensive glucose control after allogeneic hematopoietic stem cell transplantation: a retrospective matched-cohort study

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