Insulin‐induced oedema in children and adolescents

Mamoulakis, Dimitrios; Bitsori, María; Galanakis, Emmanouil; Raissaki, Maria; Kalmanti, Maria

doi:10.1111/j.1440-1754.2006.00911.x

Cited by 21 publications

(18 citation statements)

References 9 publications

(32 reference statements)

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“…As in our case, there are reports that insulin oedema resolves spontaneously without treatment 3. It is interesting to note that many children with insulin oedema have a low BMI 3…”

Section: Discussionsupporting

confidence: 70%

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Bilateral cataracts and insulin oedema in a child with type 1 diabetes mellitus

2013

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SUMMARYWe describe a teenage type 1 diabetic girl with painless pedal oedema and bilateral cataracts. She developed oedema after commencement of intensive insulin therapy and achievement of excellent glycaemic control. In addition, she was also found to have bilateral subcapsular cataracts. The oedema subsided spontaneously and she underwent surgical treatment for the cataracts. Insulin oedema is a rare complication of insulin therapy. To our knowledge, co-occurrence of these two complications in a young diabetic patient has not been described before in the English language medical literature. BACKGROUND

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“…As in our case, there are reports that insulin oedema resolves spontaneously without treatment 3. It is interesting to note that many children with insulin oedema have a low BMI 3…”

Section: Discussionsupporting

confidence: 70%

“…The first case of insulin oedema in a child with diabetes was described by Lawrence2 in 1979. Since then, 12 cases of insulin oedema in children have been reported 3 4…”

Section: Discussionmentioning

confidence: 99%

Bilateral cataracts and insulin oedema in a child with type 1 diabetes mellitus

2013

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“…Examples including pregnancy (Bamigboye and Smyth 2007), simulated air travel (Landgraf et al 1994), and investigations aimed at better understanding medical conditions such as sleep apnea (BlankWeld et al 2004), chronic venous disorders (Meissner et al 2007), compartment syndrome (Verleisdonk 2002), congestive heart failure (Madias et al 2003), diabetes (Mamoulakis et al 2006), and pulmonary hypertension (Cheung 2007). We are interested in leg edema as a marker of skeletal muscle injury (O'Connor et al 2002).…”

Section: Introductionmentioning

confidence: 98%

High day-to-day reliability in lower leg volume measured by water displacement

Pasley

O’Connor

2008

Eur J Appl Physiol

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The day-to-day reliability of lower leg volume is poorly documented. This investigation determined the day-to-day reliability of lower leg volume (soleus and gastrocnemius) measured using water displacement. Thirty young adults (15 men and 15 women) had their right lower leg volume measured by water displacement on five separate occasions. The participants performed normal activities of daily living and were measured at the same time of day after being seated for 30 min. The results revealed a high day-to-day reliability for lower leg volume. The mean percentage change in lower leg volume across days compared to day 1 ranged between 0 and 0.37%. The mean within subjects coefficient of variation in lower leg volume was 0.72% and the coefficient of variation for the entire sample across days ranged from 5.66 to 6.32%. A two way mixed model intraclass correlation (30 subjects x 5 days) showed that the lower leg volume measurement was highly reliable (ICC = 0.972). Foot and total lower leg volumes showed similarly high reliability. Water displacement offers a cost effective and reliable solution for the measurement of lower leg edema across days.

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“…Reported cases of insulin-induced oedema in childhood and adolescence are scarce (1, 5). The first pediatric report dates back to 1979 (6), and ten more cases have been reported since then (6, 7, 8, 9). Herein we describe insulin oedema in two adolescent girls with newly diagnosed diabetes.…”

Section: Introductionmentioning

confidence: 99%

Insulin Oedema in Newly Diagnosed Type 1 Diabetes Mellitus

Baş¹,

Çeti̇nkaya²,

Ağladıoğlu³

et al. 2010

JCRPE

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Despite the essential role of insulin in the management of patients with insulin deficiency, insulin use can lead to adverse effects such as hypoglycaemia and weight gain. Rarely, crucial fluid retention can occur with insulin therapy, resulting in an oedematous condition. Peripheral or generalised oedema is an extremely rare complication of insulin therapy in the absence of heart, liver or renal involvement. It has been reported in newly diagnosed type 1 diabetes, in poorly controlled type 2 diabetes following the initiation of insulin therapy, and in underweight patients on large doses of insulin. The oedema occurs shortly after the initiation of intensive insulin therapy. We describe two adolescent girls with newly diagnosed type 1 diabetes, who presented with oedema of the lower extremities approximately one week after the initiation of insulin treatment; other causes of oedema were excluded. Spontaneous recovery was observed in both patients.Conflict of interest:None declared.

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Insulin‐induced oedema in children and adolescents

Cited by 21 publications

References 9 publications

Bilateral cataracts and insulin oedema in a child with type 1 diabetes mellitus

Bilateral cataracts and insulin oedema in a child with type 1 diabetes mellitus

High day-to-day reliability in lower leg volume measured by water displacement

Insulin Oedema in Newly Diagnosed Type 1 Diabetes Mellitus

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