Insulin/FOXO Signaling Regulates Ovarian Prostaglandins Critical for Reproduction

Edmonds, Johnathan W.; Prasain, Jeevan K.; Dorand, Dixon; Yang, Youfeng; Hoang, Hieu D.; Vibbert, Jack; Kubagawa, Homare M.; Miller, Michael A.

doi:10.1016/j.devcel.2010.11.005

Cited by 80 publications

(166 citation statements)

References 66 publications

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“…As FOXO proteins have important effects on the cell, changes in the expression of FOXO proteins are associated with the physiological or pathological processes of aging, angiogenesis, cancer, diabetes, infertility (14), immune system disorders (15) and neurodegeneration (16).…”

Section: Introductionmentioning

confidence: 99%

Post-translational modifications of FOXO family proteins

Wang

Huang

2016

Molecular Medicine Reports

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Abstract. The Forkhead box O (FOXO) protein family is predominantly involved in apoptosis, oxidative stress, DNA damage/repair, tumor angiogenesis, glycometabolism, regulating life span and other important biological processes. Its activity is affected by a variety of posttranslational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, methylation and glycosylation. When cells are subjected to different environments, the corresponding PTMs act on the FOXO protein family, to change transcriptional activity or subcellular localization, and the expression of downstream target genes, will ultimately affect the biological behavior of the cells. In this review, we will discuss the biological characteristics of FOXO protein PTMs.

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Section: Introductionmentioning

confidence: 99%

Post-translational modifications of FOXO family proteins

Wang

Huang

2016

Molecular Medicine Reports

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“…Others have introduced free fatty acids to C. elegans using a DMSO or ethanol carrier, or else by directly adding fatty acids by microinjection into the vulva [12][13][14] . Partial rescue of mutant phenotypes was achieved by fatty acid supplementation of growth plates without the use of Tergitol(NP40) [14][15] .…”

Section: Discussionmentioning

confidence: 99%

Dietary Supplementation of Polyunsaturated Fatty Acids in <em>Caenorhabditis elegans</em>

Deline

Vrablik

Watts

2013

JoVE

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Fatty acids are essential for numerous cellular functions. They serve as efficient energy storage molecules, make up the hydrophobic core of membranes, and participate in various signaling pathways. Caenorhabditis elegans synthesizes all of the enzymes necessary to produce a range of omega-6 and omega-3 fatty acids. This, combined with the simple anatomy and range of available genetic tools, make it an attractive model to study fatty acid function. In order to investigate the genetic pathways that mediate the physiological effects of dietary fatty acids, we have developed a method to supplement the C. elegans diet with unsaturated fatty acids. Supplementation is an effective means to alter the fatty acid composition of worms and can also be used to rescue defects in fatty acid-deficient mutants. Our method uses nematode growth medium agar (NGM) supplemented with fatty acidsodium salts. The fatty acids in the supplemented plates become incorporated into the membranes of the bacterial food source, which is then taken up by the C. elegans that feed on the supplemented bacteria. We also describe a gas chromatography protocol to monitor the changes in fatty acid composition that occur in supplemented worms. This is an efficient way to supplement the diets of both large and small populations of C. elegans, allowing for a range of applications for this method. Video LinkThe video component of this article can be found at

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“…During mating amoeboid sperm are injected into the uterus and then crawl to the spermathecae where fertilization occurs (Figure 3) [15,51,52]. In C. elegans, migration of sperm to the spermathecae is in response to prostaglandins signals that are secreted from oocytes [51,52].…”

Section: Assortative Fertilizationmentioning

confidence: 99%

Reproductive isolation in the Elegans-Group of Caenorhabditis

Baird¹,

Seibert²

2013

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Reproductive isolation is the basis of the Biological Species Definition and can be a driving force of speciation. Theoretical studies have provided models of how reproductive isolation can arise within individual species. Genetic tests of these models are limited to populations in which reproductive isolation is present but not complete. Here, reproductive isolation in the ElgansGroup of the nematode genus Caenorhabditis is reviewed. Pre-mating barriers, assortative fertilization and post-zygotic barriers all have been observed in this clade. In some combinations of species, fertile F1 hybrids can be obtained. Therefore, the Elegans-Group of Caenorhabditis is poised to become an important experimental system for the study of reproductive isolation.

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Insulin/FOXO Signaling Regulates Ovarian Prostaglandins Critical for Reproduction

Cited by 80 publications

References 66 publications

Post-translational modifications of FOXO family proteins

Post-translational modifications of FOXO family proteins

Dietary Supplementation of Polyunsaturated Fatty Acids in <em>Caenorhabditis elegans</em>

Reproductive isolation in the Elegans-Group of Caenorhabditis

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