Insulin dysregulation in horses with systemic inflammatory response syndrome

Bertin, F.; Ruffin-Taylor, Debra; Stewart, Allison J.

doi:10.1111/jvim.15138

Cited by 23 publications

(20 citation statements)

References 56 publications

(145 reference statements)

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“…Blood glucose was determined by a handheld glucometer validated for use in horses (OneTouch Ultra; LifeScan, Wayne, PA, USA) [42]. Hyperglycemia was diagnosed with blood glucose concentrations above 124 mg/dL [43]. Blood samples for insulin were collected in red top tubes and kept at room temperature to allow samples to clot for at least 1 hour.…”

Section: Blood Glucose and Insulin Analysismentioning

confidence: 99%

Evaluation of Peripheral Blood Neutrophil Functions after an Oral Carbohydrate Overload in Obese and Insulin Resistant Horses

Salinas¹,

Espinosa²,

Morales³

et al. 2020

Preprint

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Background: Obesity and insulin resistance (IR) are conditions of increasing prevalence in populations of equids worldwide. The immune impairment described in metabolic dysfunction status in humans has been extensively reported with minimal data regarding horses. The objective of the study was to evaluate the effect of obesity as an isolated factor and in association with insulin resistance on apoptosis, phagocytosis and oxidative burst activity of neutrophils isolated from peripheral blood of lean and obese adult horses with or without insulin resistance, basally and after induction of hyperglycemia through an oral glucose test. Results: No differences in apoptosis were observed between experimental groups at any time point. Phagocytic capacity was significantly diminished at baseline in the obese-IR group (P<0.05) but increased after stimulation of hyperglycemia (P=0.007). Basal reactive oxygen species production differed significantly (P=0.0001) between the obese-insulin sensitive (IS) and lean-IS or obese-IR groups, and decreased significantly after stimulation of hyperglycemia in the lean-IS and obese-IS groups (P<0.05).Conclusions: Results from this study showed that both metabolic status itself, and acute hyperglycemia, are factors that influence PMNs functionality in horses, specifically phagocytosis and oxidative burst. This indicates the need for close monitoring of immune function in horses with inflammatory disease and concurrent obesity and insulin resistance.

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Section: Blood Glucose and Insulin Analysismentioning

confidence: 99%

Evaluation of Peripheral Blood Neutrophil Functions after an Oral Carbohydrate Overload in Obese and Insulin Resistant Horses

Salinas¹,

Espinosa²,

Morales³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…In this study François‐René Bertin and colleagues in Australia and the USA investigated insulin and glucose dynamics in horses with systemic inflammatory response syndrome (SIRS), and the association with survival .…”

Section: Insulin Dysregulation In Horses With Sirsmentioning

confidence: 99%

Highlights of recent clinically relevant papers

Wright¹

2018

Equine Veterinary Education

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“…Monitoring glucose homeostasis both in people and horses is increasingly important in terms of management of critical patients (systemic inflammatory response syndrome, sepsis, hyperlipaemia), patients receiving parenteral nutrition and patients investigated for diabetes or insulin dysregulation (ID) 1–9. Conventional methods of monitoring blood glucose including point-of-care glucometers (POCs) and enzymatic ultraviolet tests are routinely used in diagnostic settings.…”

Section: Introductionmentioning

confidence: 99%

Comparison of a continuous indwelling glucometer with a point‐of‐care device in healthy adult horses

et al. 2020

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BackgroundBlood glucose is tightly regulated in horses; however, since hypoglycaemia and hyperglycaemia are associated with poor prognosis, close monitoring is warranted. This study aimed at evaluating a continuous indwelling glucometer (CIG) by comparing performance with a point-of-care glucometer (POC).MethodsTen horses were equipped with CIG and an intravenous catheter. Interstitial glucose concentrations were determined by CIG every 5 min at rest, during insulin-induced hypoglycaemia and dextrose-induced hyperglycaemia, and compared with blood glucose determined by POC. Glucose concentrations were compared by two-way repeated measures analysis of variance and weighted kappa with Bland-Altman plots to determine agreement between assays.ResultsHorses tolerated CIG well; however, five devices had to be replaced. There were no statistically significant differences between assays at rest or during hyperglycaemia; however, during hypoglycaemia, glucose concentrations determined by CIG were significantly higher (P=0.01). The mean bias (95% limits of agreement) between assays ranged from −0.03 (−2.46 to 2.52) mmol/l (hyperglycaemia) to 0.97 (−1.23 to 3.16) mmol/l (hypoglycaemia). Assay agreement was ‘good’ with observed agreements of 87.04% (κ=0.67).Conclusions of the studyCIG has acceptable accuracy in horses as compared with POC but overestimates glucose concentrations during hypoglycaemia and requires frequent replacement, limiting its clinical application.

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Insulin dysregulation in horses with systemic inflammatory response syndrome

Cited by 23 publications

References 56 publications

Evaluation of Peripheral Blood Neutrophil Functions after an Oral Carbohydrate Overload in Obese and Insulin Resistant Horses

Evaluation of Peripheral Blood Neutrophil Functions after an Oral Carbohydrate Overload in Obese and Insulin Resistant Horses

Highlights of recent clinically relevant papers

Comparison of a continuous indwelling glucometer with a point‐of‐care device in healthy adult horses

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