Insulin-driven translational capacity is impaired in primary fibroblasts of Prader Willi

Meneghello, Cristiana; Segat, Daniela; Fortunati, Elisabetta

doi:10.5582/irdr.2015.01041

Cited by 1 publication

(1 citation statement)

References 28 publications

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“…Moreover, the homeostasis model assessment of insulin resistance differs in populations in different countries. 29 – 34 Given China's diabetic population and the particularities of the Asian physique, this study will facilitate and guide cost-effective bariatric surgery for China specifically but for the rest of Asia as well.…”

Section: Discussionmentioning

confidence: 99%

Cost-Effectiveness of Bariatric Surgery for Type 2 Diabetes Mellitus

et al. 2016

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To compare the remission of type 2 diabetes mellitus (T2DM) through treatment with laparoscopic sleeve gastrectomy (LSG) or laparoscopic Roux-en-Y gastric bypass (LRYGB), and to analyze the cost-effectiveness of medical treatment, LSG, and LRYGB in T2DM patients (BMI ≥ 28).A 2-group randomized controlled trial was conducted at Diabetes Surgery Centre, Beijing Shijitan Hospital in Beijing, China. Subjects were 80 patients ages 16 to 65 years with a body mass index of 28 kg/m2 or more and duration of T2DM no more than 15 years. Subjects were randomly assigned (1:1) to undergo either LSG (n = 40) or LRYGB (n = 40) between February 3, 2011 and October 31, 2013. Of those patients, 72 (90%) were available at follow-up at 2 years. These patients included 34 (85%) who underwent LSG and 38 (95%) who underwent LRYGB. This study presents the follow-up data at 2 years, which compared LSG and LRYGB in T2DM patients. Partial remission and complete remission were determined, and weight loss, BMI, changes in abdominal circumference, cholesterol, and triglycerides were measured. The cost-effectiveness of each type of bariatric surgery was analyzed with a Markov simulation model that yielded quality-adjusted life-years (QALYs) and costs.From our analysis results, LSG and LRYGB are both have taken a great effect on the reduction of fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), and bodyweight in patients with T2DM. The cost-effectiveness ratios of medical treatment, LSG, and LRYGB respectively are 1589.02, 1028.97, and 1197.44 dollars per QALY.Our analysis indicates that LSG appear to provide a cost-effective method of T2DM treatment for the patients.

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Section: Discussionmentioning

confidence: 99%