Insulin delivery systems combined with microneedle technology

Xu, Jin; Zhu, Dan; Chen, Bo Zhi; Ashfaq, Mohammad; Guo, Xin Dong

doi:10.1016/j.addr.2018.03.011

Cited by 217 publications

(147 citation statements)

References 221 publications

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“…In summary, we developed an “enzyme‐free” polymeric MN‐array patch composed of a boronate‐gel/SF semi‐IPN hydrogel, which can provide on‐demand and automated insulin delivery with an aqueous stability of at least 2 months and a sustained performance durability. Achieving both (at once) fast and long‐lasting glucose‐responsiveness has been a challenge with currently available chemically controlled closed‐loop systems . Note that all reported GO x ‐nanoparticle‐based insulin‐loaded MNs suffer from a short duration of action (typically on the order of several hours even for small animals), due to their burst‐responsive and transient (irreversible particle disassociation) natures .…”

Section: Resultsmentioning

confidence: 99%

“…Meanwhile, electronics‐free, chemically controlled, glucose‐responsive insulin delivery systems are of continuous interest. One highlight of recent efforts is the formulation of microneedles (MNs) comprised of an array of micrometer‐sized sharp needles capable of effectively disrupting the stratum corneum and transdermally delivering insulin in a noninvasive (painless) manner . For example, Gu and co‐workers reported a series of smart insulin MN patches embedding glucose oxidase (GO x )‐encapsulated polymeric nanoparticles that are able to secrete insulin in response to glucose .…”

Section: Introductionmentioning

confidence: 99%

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Microneedle‐Array Patch Fabricated with Enzyme‐Free Polymeric Components Capable of On‐Demand Insulin Delivery

Chen

Matsumoto

Moro-oka

et al. 2018

Adv Funct Materials

107

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Achieving persistent glycemic control in a painless and convenient way is the ultimate goal of diabetes management. Herein, an "enzyme-free" polymeric microneedle (MN)-array patch composed of a boronate-containing hydrogel semi-interpenetrated by biocompatible silk fibroin is developed. Consistent with the previous reports, the presence of the boronate-hydrogel allows for glucose-responsive diffusion-control of insulin, while the crystalline fibroin component serves as a matrix-stiffener to validate skin penetration. Remarkably, this "enzyme-free" smart artificial on-skin pancreas prototype remains stable for at least 2 months in an aqueous environment. Furthermore, it establishes sustained as well as acute glucose-responsive insulin delivery, and is to the authors' knowledge, the first successful material design addressing such two technical challenges at once on an MN format. This long-acting, on-demand insulin delivery technology may offer a candidate for a next-generation diabetes therapy that is remarkably stable, safe, economically efficient, and capable of providing both acute-and continuous glycemic control in a manner minimally dependent on patient compliance.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microneedle‐Array Patch Fabricated with Enzyme‐Free Polymeric Components Capable of On‐Demand Insulin Delivery

Chen

Matsumoto

Moro-oka

et al. 2018

Adv Funct Materials

107

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“…In this case, microneedles are applied as a pretreatment, whereafter the vaccine is applied topically as a formulation. We note that much of the early work on microneedles was used to deliver insulin for diabetic patients, but that work has been carefully reviewed elsewhere …”

Section: Macroscale Materials For Immunotherapymentioning

confidence: 99%

Materials for Immunotherapy

et al. 2019

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Breakthroughs in materials engineering have accelerated the progress of immunotherapy in preclinical studies. The interplay of chemistry and materials has resulted in improved loading, targeting, and release of immunomodulatory agents. An overview of the materials that are used to enable or improve the success of immunotherapies in preclinical studies is presented, from immunosuppressive to proinflammatory strategies, with particular emphasis on technologies poised for clinical translation. The materials are organized based on their characteristic length scale, whereby the enabling feature of each technology is organized by the structure of that material. For example, the mechanisms by which i) nanoscale materials can improve targeting and infiltration of immunomodulatory payloads into tissues and cells, ii) microscale materials can facilitate cell‐mediated transport and serve as artificial antigen‐presenting cells, and iii) macroscale materials can form the basis of artificial microenvironments to promote cell infiltration and reprogramming are discussed. As a step toward establishing a set of design rules for future immunotherapies, materials that intrinsically activate or suppress the immune system are reviewed. Finally, a brief outlook on the trajectory of these systems and how they may be improved to address unsolved challenges in cancer, infectious diseases, and autoimmunity is presented.

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“…Dependent on time of exposure and viscosity of the formulations 12 Considerable variations in bioavailability 56…”

Section: Route Of Administration Advantages Disadvantages Intranasal mentioning

confidence: 99%

Non-Invasive and Less Degradative Ways of Insulin Administration

Allahyari

Javadzadeh

2019

Pharm Sci

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Protein and peptide delivery systems attract great attention nowadays. They play crucial role in several diseases, but their way of administration has some disadvantages that makes patients dissatisfied. In this study, we choose insulin as a peptide that is used for type I and type II diabetic patients, but injection way of its usage is not suitable in diabetes as a chronic remedy. Although oral way is a needle-free one, but its bioavailability through that would be decreased because of degradation in gastro-intestine and consequently, further dosage should be used to get the desired hypoglycemic effect. Administration of insulin through non-parenteral and less enzymatic pathways, such as intranasal, pulmonary, transdermal, colon and vaginal routes, is new that attracts researchers’ attention considerably. Although the bioavailability of insulin may be lower than the current injection way, but it may be improved by some strategies like the use of permeation enhancers. There are also some limitations in each way, but propagation of them would result in improvement of patients’ quality of life and may cause some economic profits. The objective of this review was to introduce the convenient ways for long term insulin administration with few enzymatic barriers.

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Insulin delivery systems combined with microneedle technology

Cited by 217 publications

References 221 publications

Microneedle‐Array Patch Fabricated with Enzyme‐Free Polymeric Components Capable of On‐Demand Insulin Delivery

Microneedle‐Array Patch Fabricated with Enzyme‐Free Polymeric Components Capable of On‐Demand Insulin Delivery

Materials for Immunotherapy

Non-Invasive and Less Degradative Ways of Insulin Administration

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