Insulin decreases intracellular oxidative stress in patients with type 2 diabetes mellitus

Bravi, M.; Armiento, A.; Laurenti, O.; Cassone-Faldetta, M.; Luca, Ottavia De; Moretti, Arianna; Mattia, G. De

doi:10.1016/j.metabol.2006.01.003

Cited by 67 publications

(40 citation statements)

References 35 publications

(28 reference statements)

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“…NA, not applicable. diabetic versus healthy individuals (27,28). We found that intracellular GSH concentrations and the GSH/GSSG ratios in white blood cells of diabetic patients were also significantly lower than those from healthy controls.…”

Section: Discussionmentioning

confidence: 63%

Glutathione deficiency in type 2 diabetes impairs cytokine responses and control of intracellular bacteria

Tan

Lee²,

Low³

et al. 2012

J. Clin. Invest.

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Individuals with type 2 diabetes are at increased risk of acquiring melioidosis, a disease caused by Burkholderia pseudomallei infection. Although up to half of melioidosis patients have underlying diabetes, the mechanisms involved in this increased susceptibility are unknown. We found that B. pseudomallei-infected PBMCs from diabetic patients were impaired in IL-12p70 production, which resulted in decreased IFN-γ induction and poor bacterial killing. The defect was specific to the IL-12-IFN-γ axis. Defective IL-12 production was also observed during Mycobacterium tuberculosis infection, in which diabetes is likewise known to be a strong risk factor. In contrast,

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Section: Discussionmentioning

confidence: 63%

Glutathione deficiency in type 2 diabetes impairs cytokine responses and control of intracellular bacteria

Tan

Lee²,

Low³

et al. 2012

J. Clin. Invest.

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“…Glycated hemoglobin (HbA 1C ) was found to increase in the patients with uncontrolled or poorly controlled diabetes mellitus and amount of increase is directly proportional to the hyperglycemic state (32). Evidence showed that glycation itself may induce the formation of oxygen-derived free radicals in diabetic condition, and the level of HbA 1C is considered as one of the markers of degree of oxidative stress in diabetes mellitus (33). Therefore, the measurement of HbA 1C is supposed to be a very sensitive index for glycemic control (34).…”

Section: Discussionmentioning

confidence: 99%

Attenuation of oxidative stress in streptozotocin-induced diabetic rats by Eucalyptus globulus

Nakhaee

Bokaeian

Saravani

et al. 2009

Indian J Clin Biochem

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In traditional medicine, Eucalyptus globulus (eucalyptus) was used for the treatment of diabetes mellitus. Hyperglycemia in diabetes has been associated with increased formation of reactive oxygen species (ROS) and oxidative damage to tissue compounds. The aim of this study was to evaluate the effects of eucalyptus in the diet (20 g/Kg) and drinking water (2.5 g/L) on lipid peroxidation, protein oxidation and antioxidant power in plasma and liver homogenate, as well as glycated-Hb (HbA(1C)) of blood in streptozotocin-induced diabetic rats for a period of 4 weeks. Diabetes induced in rats by a single intraperitoneal injection of streptozotocin (STZ, 65 mg/Kg). At the end of the treatment period, the level of plasma glucose, plasma and liver malondialdehyde (MDA, the main product of lipid peroxidation), protein carbonyl (PC, one of the protein oxidation products) and HbA(1C) increased and ferric reducing antioxidant power (FRAP) decreased in diabetic rats compared to normal rats. Eucalyptus administration for 4 weeks caused a significant decrease in the plasma glucose levels, plasma and liver MDA, PC and HbA(1C), also a concomitant increase in the levels of FRAP in diabetic treated rats. In conclusion, the present study showed that eucalyptus posses antioxidant activities. Eucalyptus probably restores antioxidant power, due to the improved hyperglycemia in streptozotocin-induced diabetic rats.

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“…They proposed that the GSH redox system of aged subjects with diabetes is stimulated by the condition itself and/or its treatment with oral hypoglycaemics and insulin (Matsubara, Ferreira et al 1992). Indeed, a study using in vivo euglycaemic hyperinsulinaemic clamping, found that administered insulin reduces RBC oxidative stress and results in a higher GSH/GSSG ratio in NIDDM patients to almost normal levels after 2 h (Bravi, Armiento et al 2006). The decline in HbA 1c seen in the NIDDM group in the present study suggests good management of the condition, and/or a decline in the oxidative load; and it may be that the treatment and management of the NIDDM patients stimulated the GSH biosynthetic pathway.…”

Section: Discussion Of the Resultsmentioning

confidence: 99%

Oxidative Stress in Type II Diabetes Mellitus and the Role of the Endogenous Antioxidant Glutathione

Whillier¹,

Kuchel²,

Raftos³

2011

Role of the Adipocyte in Development of Type 2 Diabetes

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Insulin decreases intracellular oxidative stress in patients with type 2 diabetes mellitus

Cited by 67 publications

References 35 publications

Glutathione deficiency in type 2 diabetes impairs cytokine responses and control of intracellular bacteria

Glutathione deficiency in type 2 diabetes impairs cytokine responses and control of intracellular bacteria

Attenuation of oxidative stress in streptozotocin-induced diabetic rats by Eucalyptus globulus

Oxidative Stress in Type II Diabetes Mellitus and the Role of the Endogenous Antioxidant Glutathione

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