Insulin Concentrations in Portal Venous and Peripheral Venous Blood in Man Following Administration of Glucose, Galactose, Xylitol and Tolbutamide

Berger, W; Göschke, H; J, Moppert; Künzli, Hannah T.

doi:10.1055/s-0028-1093991

Cited by 27 publications

(12 citation statements)

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“…Prehepatic insulin production was determined during the steady states ofbasal and 20. Evidence to support the assumptions upon which this method is based have been published (16,17,21,29) and the estimates of prehepatic insulin production and portal vein insulin concentration were concordant with those determined by portal vein and hepatic vein catheterization studies (36)(37)(38)(39). It is not known whether the pancreatic hypersecretion of insulin is a primary event or an adaptive response to the diminished insulin sensitivity of the obese state.…”

Section: Resultsmentioning

confidence: 79%

Splanchnic insulin metabolism in obesity. Influence of body fat distribution.

Peiris¹,

Mueller²,

Smith³

et al. 1986

J. Clin. Invest.

323

143

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The effects of obesity and body fat distribution on splanchnic insulin metabolism and the relationship to peripheral insulin sensitivity were assessed in 6 nonobese and 16 obese premenopausal women.When compared with the nonobese women, obese women had significantly greater prehepatic production and portal vein levels of insulin both basally and following glucose stimulation. This increase correlated with the degree of adiposity but not with waist-to-hip girth ratio (WHR). WHR, however, correlated inversely with the hepatic extraction fraction and directly with the posthepatic delivery of insulin. The latter correlated with the degree of peripheral insulinemia. The decline in hepatic insulin extraction with increasing WHR also correlated with the accompanying diminution in peripheral insulin sensitivity.Increasing adiposity is thus associated with insulin hypersecretion. The pronounced hyperinsulinemia of upper body fat localization, however, is due to an additional defect in hepatic insulin extraction. This defect is closely allied with the decline in peripheral insulin sensitivity.

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Section: Resultsmentioning

confidence: 79%

Splanchnic insulin metabolism in obesity. Influence of body fat distribution.

Peiris¹,

Mueller²,

Smith³

et al. 1986

J. Clin. Invest.

323

143

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“…However, because the liver has been shown to be the most important organ for removal of insulin from the circulation (14,15), studies of simultaneously obtained portal and peripheral blood samples have been carried out to determine how well peripheral levels reflect those in the portal vein (8,(16)(17)(18)(19). The results of these previous studies have indicated that while portal and peripheral values generally correlate with each other, significant quantitative differences do occur.…”

Section: Discussionmentioning

confidence: 92%

Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood.

Horwitz¹,

Starr²,

Mako³

et al. 1975

J. Clin. Invest.

476

229

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A B S T R A C T Concentrations of insulin, proinsulin, and C-peptide were measured in portal and peripheral venous blood in six nondiabetic, nonobese subjects. Portal vein samples were obtained by umbilical vein catheterization. Three subj ects were studied with intravenous infusion of 25 g glucose, and three with 30 g arginine. Insulin and proinsulin were determined in the insulin immunoassay after separation by gel filtration, and C-peptide was measured by direct immunoassay.With both glucose and arginine stimulation, portal vein levels of all three peptides peaked at 90-120 s after the onset of the stimulus. Relative increases in insulin concentration were greater than those of proinsulin or C-peptide. In peripheral venous blood, maximal levels of the three peptides were observed later (2-5 min), and the increase in insulin relative to proinsulin and C-peptide was not as great. At the time of peak secretion, portal vein insulin and C-peptide approached equimolar concentrations, and proinsulin, as measured against an insulin standard, comprised approximately 2.5% of the total immunoreactive insulin.After stimulation by glucose or arginine, portal insulin, proinsulin, and C-peptide levels were not correlated with the concentrations measured in simultaneously drawn peripheral samples. At all sampling times, however, significant correlation was found between insulin and C-peptide in both peripheral and portal blood. The results indicate that under the conditions studied, insulin and C-peptide are secreted in equimolar concentrations in man, and that proinsulin is secreted in the same proportion to insulin as found in the pancreas.

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“…After administration of sulfonylurea the changes of arterial insulin levels are in a relatively good correlation with the changes of portal venous insulin levels [2,3,11,18]; this correlation is most probably much better than the correlation between peripheral venous insulin levels and portal venous insulin levels. In addition--as mentioned above--the continuous sampling of arterial blood allows a statement about the rapid changes of insulin levels after sulfonylurea and the beginning of insulin delivery into the circulating blood.…”

Section: Discussionmentioning

confidence: 99%

The early phase of insulin release in man — a new method for quantitative analysis

Dörfler¹,

Wolfram²,

Zöllner³

1977

Res. Exp. Med.

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A method is presented for the quantitative analysis of early insulin release in man. There were measured arterial insulin levels after glibornuride administered intravenously. The mathematical procedure has been modified: Modification I is based on the assumption that early insulin release represents a wave like insulin delivery, modification II is based on the assumption that this insulin bolus is immediately followed by a slower insulin release which must be distinguished from the second phase of insulin release. For the calculations there was used a "primary insulin space" derived from experiments with exogenous insulin. The results of calculations were varying up to 1.5 units of early insulin release in healthy volunteers receiving glibornuride with dosages varying up to 50 mg. The value of the presented method for examinations of insulin release for theoretical and clinical purposes is discussed.

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Insulin Concentrations in Portal Venous and Peripheral Venous Blood in Man Following Administration of Glucose, Galactose, Xylitol and Tolbutamide

Cited by 27 publications

References 0 publications

Splanchnic insulin metabolism in obesity. Influence of body fat distribution.

Splanchnic insulin metabolism in obesity. Influence of body fat distribution.

Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood.

The early phase of insulin release in man — a new method for quantitative analysis

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