Insulin at the Intersection of Thermoregulation and Glucose Homeostasis
Nathan C. Winn,
Michael W. Schleh,
Jamie N. Garcia
et al.
Abstract:Mammals are protected from changes in environmental temperature by altering energetic processes that modify heat production. Insulin is the dominant stimulus of glucose uptake and metabolism, which are fundamental for thermogenic processes. The purpose of this work was to determine the interaction of ambient temperature induced changes in energy expenditure (EE) on the insulin sensitivity of glucose fluxes. Short-term and adaptive responses to thermoneutral temperature (TN, ∼28°C) and room (laboratory) tempera… Show more
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