Insulin-Antibodies and Azathioprine (Imurel^®)

Abstract

The pattern of response of plasma insulin and glucose to meals and fasting during chlorpropamide therapy. Ann.

Glomerular Vascular Changes in KK-Ay Mice with Early Diabetes: Scanning Electron Microscopy of Vascular Resin Casts.

“…Use of this technique provided a clear demonstration of the increase in diameter of glomerular fine vessels in early diabetes. These findings confirmed previous histological studies [5,10]. Diameters of the afferent arteriole, glomerular capillary and efferent arteriole were greater in the early diabetic animals than in the normal controls, vis.…”

“…Although segmental thickening of the basement membrane and proliferation of cells have been observed in diabetic KK mice from 2 to 4 months old [7,9, 10], we could not find these glomerular changes in the present study. However, our findings regarding the dilation of capillaries in the glomeruli of young diabetic mice are consistent with the findings of one other author [10].…”

“…There was neither capillary proliferation, distorition of fine glomerular vessels nor destruction of the glomerular Congenital diabetes mellitus has been reported in NOD, C57BL/ob, C57BL/db, KK, NZO and NON mice, BB, GK, Zucker fatty rats, hamsters and other animals [3]. Glomerular lesions similar to those found in human diabetes have been studied with these animals [7][8][9][10]. Swelling of the glomerulus, expansion of glomerular capillary lumina and enhanced glomerular perfusion are reported to be major symptoms during the initial stage of the disease [1,4,5,10].…”

“…Since early diabetic changes such as a diffuse sclerosis of the mesangium were already found in young animals [9,10], the age of the diabetic animals was 4 months. The mice were killed by an overdose of anesthetic ether.…”

“…Glomerulosclerosis, diffuse sclerosis of mesangium and thickening of basal laminae and proliferation of glomerular cells can be observed in young KK mice (2 to 4 months old) [9,10]. Abnormal glucose tolerance begins at 4 months of age in the animals [7].…”