Insulin and Variation in Glucose Levels Modify the Secretion Rates of the Growth Hormone-Independent Insulin-Like Growth Factor Binding Protein-1 in the Human Hepatoblastoma Cell Line Hep G2

Cotterill, A M; Cowell, CT; Silink, Martin

doi:10.1677/joe.0.123r017

Cited by 28 publications

(24 citation statements)

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“…In patients with T1DM, subcutaneous insulin injections do not restore physiologic intraportal insulin levels. Moreover, insulin modulates hepatic GH receptor expression and postreceptor pathways [21,22] and negatively modulates the expression of IGFBP-1, thus increasing IGF-I bioavailability. Therefore, the high IGFBP-1 levels documented in T1DM children may significantly contribute to the growth failure [6,[23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Growth Trajectory in Children with Type 1 Diabetes Mellitus: The Impact of Insulin Treatment and Metabolic Control

et al. 2018

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Background: Linear growth was reported to be negatively affected by type 1 diabetes mellitus (T1DM), in relation to disease duration and poor metabolic control. It is unclear whether a subtle growth failure still persists despite the optimization of therapy. Our aim was to analyse pubertal growth, adult height, and metabolic profile in a cohort of children with T1DM undergoing intensive insulin treatment by multiple daily injections or continuous subcutaneous insulin infusion (CSII). Methods: One-hundred and four children (51 males) with prepubertal onset of T1DM were prospectively followed up to final height attainment. Results: Age at puberty onset was 11.7 ± 1

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Section: Discussionmentioning

confidence: 99%

Growth Trajectory in Children with Type 1 Diabetes Mellitus: The Impact of Insulin Treatment and Metabolic Control

et al. 2018

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“…It can thus be hypothesized that signi®cant alterations in IGF activity during exercise might be mediated by acute changes in plasma content of IGFBP. In particular IGFBP-1, which rapidly responds to changes in plasma concentrations of insulin and glucose (Cotterill et al 1989) has been proposed as a speci®c factor of glucoregulation through controlling the bioactivity of free circulating IGF (Baxter and Martin 1989;Lewitt et al 1991).…”

Section: Introductionmentioning

confidence: 99%

Influence of exercise duration on serum insulin-like growth factor and its binding proteins in athletes

Nguyen

Mougin

Simon-Rigaud³

et al. 1998

European Journal of Applied Physiology

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The changes in circulating concentrations of insulin-like growth factors during exercise have to date remained incomplete in their documentation. Therefore, we examined in 25 healthy athletes the effects of three different durations of three types of exercise -- incremental ergometer cycling exercise (ICE), long-distance Nordic ski race (NSR) and a treadmill-simulated soccer game (TSG) lasting 20 min, 3 h, and 2 x 45 min separated by a 15-min half-time rest respectively, on plasma concentrations of growth hormone ([GH]), insulin-like growth factor-1 ([IGF-I]) and its binding proteins 1 and 3 ([IGFBP-1], [IGFBP-3]). Compared to baseline, serum [GH] increased by 15.2-fold after ICE (P < 0.001), 2.9-fold after NSR (P < 0.01) and 4.6-fold after TSG. Serum [IGF-I] rose by 11.9% after ICE (P < 0.001), while it decreased by -14.6% after NSR (P < 0.001) and was unchanged after TSG. Serum [IGFBP-1] was slightly increased (1.7-fold) after ICE (P < 0.01), but increased markedly (11.8-fold) after NSR (P < 0.001) and by 6.3-fold after the second session of TSG (P < 0.01) (it remained unchanged at the end of the first period of TSG, i.e. after 45-min exercise). The [IGFBP-3] increased by 14.7% after ICE (P < 0.001) and by 6% after TSG (P < 0.05) while it did not change after NSR. From our results it would appear that [IGFBP-1] increase to bind free IGF and hinder their insulin-like action during long-term exercise (lasting beyond 45 min). It is suggested that IGFBP-1 might thus contribute both to preventing hypoglycaemic action of IGF and to facilitating glucose uptake by muscle cells when muscle glycogen stores become deplete.

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“…Normal portal insulin concentrations are needed to determine normal serum concentrations of growth factors and promote growth. Insulin modulates the hepatic growth hormone receptor expression and postreceptor pathways [15,16]. Insulin regulates IGF-I expression [17,18,19,20], and IGF-I concentrations have been reported to be reduced in children with T1D at onset [6,21,22,23,24,25].…”

Section: Discussionmentioning

confidence: 99%

Residual β-Cell Mass Influences Growth of Prepubertal Children With Type 1 Diabetes

Bizzarri

Benevento²,

Patera³

et al. 2013

Horm Res Paediatr

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Background: The growth deceleration observed in children with type 1 diabetes (T1D) has been related to poor glycemic control. It is unclear whether growth impairment persists despite the optimization of therapy. We analyzed the effects of intensive insulin treatment on prepubertal growth. Methods: One hundred and four T1D children were evaluated from T1D diagnosis up to puberty onset. Height, weight, insulin requirement and glycated hemoglobin (HbA1c) were recorded at 3- to 6-month intervals. Residual β-cell mass was estimated by fasting C-peptide at T1D onset. Results: Age at T1D onset was 5.91 ± 1.9 years. Follow-up duration was 4.84 ± 1.58 years. Height velocity standard deviation score (SDS) was -0.14 ± 1.84. Height SDS changed from 0.52 ± 1.04 at T1D onset, to 0.36 ± 1.10 at the end of follow-up (p = 0.04). BMI SDS increased from -0.04 ± 1.48 to 0.32 ± 1.03 (p = 0.01). Multivariate analysis showed that height velocity was directly affected by C-peptide (p = 0.03) and insulin requirement (p = 0.004) and inversely related to HbA1c (p = 0.006). BMI gain was negatively influenced by HbA1c (p = 0.01) and positively related to T1D duration (p = 0.01). Conclusion: Despite insulin intensive therapy, T1D still negatively affects growth. Residual β-cell mass has a direct positive impact on growth, independently from the quality of glycemic control.

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Insulin and Variation in Glucose Levels Modify the Secretion Rates of the Growth Hormone-Independent Insulin-Like Growth Factor Binding Protein-1 in the Human Hepatoblastoma Cell Line Hep G2

Cited by 28 publications

References 0 publications

Growth Trajectory in Children with Type 1 Diabetes Mellitus: The Impact of Insulin Treatment and Metabolic Control

Growth Trajectory in Children with Type 1 Diabetes Mellitus: The Impact of Insulin Treatment and Metabolic Control

Influence of exercise duration on serum insulin-like growth factor and its binding proteins in athletes

Residual β-Cell Mass Influences Growth of Prepubertal Children With Type 1 Diabetes

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