Insulin and/or dexamethasone regulation of lactate production and its relationship to glucose utilization by ovine and bovine adipose tissue explants incubated for 7 days

Abstract

line n'a d'effet qu'à partir du 3 e jour de culture. Par ailleurs, le rapport production de lactate/utilisation de glucose est environ deux fois plus important chez la brebis que chez la vache. L'insuline augmente et la DEX diminue ce rapport dans le TA ovin mais pas dans le TA bovin. La DEX en pré-sence d'insuline augmente ce rapport chez les deux espèces après 4 ou 5 jours de culture.

Effects of maternal dexamethasone treatment on pancreatic β cell function in the pregnant mare and post natal foal

“…Increased lactate production has also been previously observed in response dexamethasone treatment in man and other species [31,32]. In the current study, the insulin-glucose dynamics of the dexamethasonetreated mares were still abnormal 72 h after ceasing treatment with significant differences in basal fasting concentrations of both insulin and glucose between the 2 treatment groups at this time.…”