Insulin and Atheroma

Stout, Robert W.; Vallance‐Owen, J.

doi:10.1016/s0140-6736(69)91711-5

Cited by 167 publications

(47 citation statements)

References 40 publications

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“…In vivo studies using insulin-treated rats with streptozotocin diabetes were not able to demonstrate any effect on the amount of hyaluronan in intima-media preparations from the aortas (22). Thus the present ®ndings support the concept of insulin as a signi®cant factor for the development of large-vessel disease in diabetes mellitus (24). However, this is not supported by previous data, although insulin receptor has been demonstrated in vascular smooth muscle cells (25).…”

Section: Discussioncontrasting

confidence: 90%

Production of hyaluronan and chondroitin sulphate proteoglycans from human arterial smooth muscle--the effect of glucose, insulin, IGF-I or growth hormone

Erikstrup¹,

Pedersen²,

Heickendorff³

et al. 2001

European Journal of Endocrinology

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Background: Although it is recognized that the extracellular matrix is important for cell proliferation, migration and metabolism of growth factors, the regulation of the synthesis of hyaluronan and chondroitin sulphate proteoglycan (CSPG) in the vessel wall is poorly understood. Objective: To examine the role of glucose, insulin, IGF-I and human growth hormone (hGH) on the accumulation of hyaluronan and CSPG using cultures of human aortic smooth muscle cells. Methods: The cultures were exposed for 36 h. The CSPG content in the incubation medium was measured by a combination of digestion with testicular hyaluronidase and precipitation of [

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Section: Discussioncontrasting

confidence: 90%

Production of hyaluronan and chondroitin sulphate proteoglycans from human arterial smooth muscle--the effect of glucose, insulin, IGF-I or growth hormone

Erikstrup¹,

Pedersen²,

Heickendorff³

et al. 2001

European Journal of Endocrinology

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“…Glucose is a toxic agent for endothelial cells of arterial walls [12]. The consequent release of tissue thromboplastin from vascular lesions might activate factor VII.…”

Section: Discussionmentioning

confidence: 99%

Blood glucose may condition factor VII levels in diabetic and normal subjects

Ceriello¹,

Giugliano²,

Quatraro

et al. 1988

Diabetologia

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Summary. Increased factor VII levels have been reported in Type 1 (insulin-dependent) diabetic subjects. A direct correlation between fasting plasma glucose and factor VII level was found to exist in both diabetic and normal subjects. Inducedhyperglycaemia was able to increase factor VII levels in both diabetic patients and normal control subjects while, when euglycaemia was achieved in diabetic patients, factor VII values returned to normal range. This study shows that the level of factor VII may be directly conditioned by circulating blood glucose and, therefore, stresses the role of hyperglycaemia in conditioning coagulation abnormalities in diabetes mellitus.

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“…Cross-sectional prevalence studies, on the other hand, have shown a correlation between the development of atherosclerosis in diabetics and the degree of insulinaemia observed in these patients [49,28]. The association of these two risk factors has been stressed in several studies [15,19,20].…”

Section: Inter-relationship Between Insulin Secretion and Plasma Freementioning

confidence: 99%

Inter-relationship between insulin secretion and plasma free fatty acid and triglyceride transport kinetics in maturity onset diabetes and the effect of phenethylbiguanide (Phenformin)

1974

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Summary. The plasma free fatty acid and triglyceride transport kinetics in 16 non-obese and 7 obese maturity onset diabetics with hypertriglyceridaemia have been compared with results obtained in 27 control subjects. Changes in glucose and insulin responses were evaluated in relation to the lipid parameters. All the diabetics showed elevated plasma FFA levels and turnover rates. In the non-obese diabetics the plasma triglyceride turnover rate was within the normal range and their hypertriglyceridaemia was due to impaired trigleeride clearance. In the obese diabetics the plasma trig]yceride turnover rate was increased and they also had some impairment of triglyceride clearance, so that in them a double mechanism was observed to account for their hypertriglyceridaemia. The insulin levels in the diabetics were similar to, or greater than, those found in the controls. Our results suggested that the enhanced lipolysis and impaired triglyceride clearance observed in the diabetic patients were a manifestation of insulin unresponsiveness in adipose tissue and that the changes in insulin and glucose relationship could be secondary to elevated FFA and triglyceride levels. Further confirmation was obtained by the finding of an exaggerated insulin response to a glucose challenge in normal subjects infused with Intralipid.Treatment with phenethylbiguanide (Phenformin) significantly lowered the plasma FFA and triglyceride concentration in both diabetic groups. This was associated with normalisation of both plasma FFA turnover and triglyceride clearance. It also reduced the triglyceride turnover rate to the normal range in the obese diabetics. These changes were associated with a fall of plasma glucose and insulin levels to within the normal range. These results suggested an effect of Phenformin in reducing the rate of lipolysis leading to improved glucose tolerance.

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Insulin and Atheroma

Cited by 167 publications

References 40 publications

Production of hyaluronan and chondroitin sulphate proteoglycans from human arterial smooth muscle--the effect of glucose, insulin, IGF-I or growth hormone

Production of hyaluronan and chondroitin sulphate proteoglycans from human arterial smooth muscle--the effect of glucose, insulin, IGF-I or growth hormone

Blood glucose may condition factor VII levels in diabetic and normal subjects

Inter-relationship between insulin secretion and plasma free fatty acid and triglyceride transport kinetics in maturity onset diabetes and the effect of phenethylbiguanide (Phenformin)

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