Insulin Alters the Permeability of Sheep Pleura

Vk, Kouritas; Hatzoglou, Chrissi; Ιωάννου, Μαρία; Ki, Gourgoulianis; Pa, Molyvdas

doi:10.1055/s-0029-1233452

Cited by 8 publications

(16 citation statements)

References 24 publications

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“…Insulin resistance and hyperglycemia may contribute to the development of reduced lung function. A recent study reported that insulin receptors are present in lung pleura and insulin can alter its physiology ( Kouritas et al, 2010 ). However, our fi nding of an association between ventilatory dysfunction and a prediabetic state (impaired fasting glucose) indicates that diminished ventilatory function is associated with insulin resistance long before the development of type 2 DM.…”

Section: Discussion ▼contrasting

confidence: 61%

Association of Restrictive Ventilatory Dysfunction with Insulin Resistance and Type 2 Diabetes in Koreans

Ch²,

Jung³

et al. 2011

Exp Clin Endocrinol Diabetes

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Section: Discussion ▼contrasting

confidence: 61%

Association of Restrictive Ventilatory Dysfunction with Insulin Resistance and Type 2 Diabetes in Koreans

Ch²,

Jung³

et al. 2011

Exp Clin Endocrinol Diabetes

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“…In an effort to explain this event, a direct effect of insulin in pleura was previously demonstrated in sheep [8]; insulin induced electrochemical changes increasing the pleural trans-mesothelial resistance ( R TM ) by blocking ion transporters such as the amiloride-sensitive Na + channels and the ouabain-sensitive Na + /K + pumps who have been implicated in pleural fluid recycling [9]. In that study, the insulin receptors a (IRa) and b (IRb) were demonstrated to be present in sheep pleura, and therefore the aforementioned effect was suggested to be mediated by a possible insulin-insulin receptor interaction [8].…”

Section: Introductionmentioning

confidence: 99%

Insulin-Induced Electrophysiology Changes in Human Pleura Are Mediated via Its Receptor

Kouritas

Ιωάννου

Foroulis

et al. 2010

Experimental Diabetes Research

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Background. Insulin directly changes the sheep pleural electrophysiology. The aim of this study was to investigate whether insulin induces similar effects in human pleura, to clarify insulin receptor's involvement, and to demonstrate if glibenclamide (hypoglycemic agent) reverses this effect. Methods. Human parietal pleural specimens were mounted in Ussing chambers. Solutions containing insulin or glibenclamide and insulin with anti-insulin antibody, anti-insulin receptor antibody, and glibenclamide were used. The transmesothelial resistance (R TM) was determined. Immunohistochemistry for the presence of Insulin Receptors (IRa, IRb) was also performed. Results. Insulin increased R TM within 1st min (P = .016), when added mesothelially which was inhibited by the anti-insulin and anti-insulin receptor antibodies. Glibenclamide also eliminated the insulin-induced changes. Immunohistochemistry verified the presence of IRa and IRb. Conclusion. Insulin induces electrochemical changes in humans as in sheep via interaction with its receptor. This effect is abolished by glibenclamide.

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“…14 Insulin changes the permeability of sheep pleura and may interfere in pleural effusion formation. 15 Pleural effusions have rarely been reported and were usually presented 4 weeks after use of insulin. 13,16,17 In previous reports, patients were found to have pleural effusions after 5 months using pioglitazone in combination with other oral hypoglycemic agents.…”

Section: Discussionmentioning

confidence: 99%

Pleural Effusion Due to Use of Pioglitazone: A Case Report

Xue

Liu

Shi

et al. 2020

Metabolic Syndrome and Related Disorders

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Background: Pioglitazone is an effective treatment option in clinical practice for managing type 2 diabetes mellitus. It is challenged by a lot of adverse effects, primarily body weight gain, peripheral edema, as well as congestive heart failure. Case Report: This is a case of a 76-year-old woman with no evidence of cardiac disease, who developed edema as well as bilateral pleural effusion after using pioglitazone. She got a weight decrease and complete resolution of the pleural effusion after stopping use of pioglitazone and rational use of diuretics. Conclusion: Common side effects of pioglitazone have been widely reported. However, little attention was drawn on pleural effusion in diabetic patients with no pre-existing heart dysfunction. In this case, we show the use of pioglitazone results in pleural effusion, with emphasis on the clinical recognition and management.

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Insulin Alters the Permeability of Sheep Pleura

Abstract: Insulin changes the permeability of sheep pleura by altering its electrophysiology and may interfere in pleural effusion formation. Involvement of Insulin Receptors may be suggested.

Cited by 8 publications

References 24 publications

Association of Restrictive Ventilatory Dysfunction with Insulin Resistance and Type 2 Diabetes in Koreans

Association of Restrictive Ventilatory Dysfunction with Insulin Resistance and Type 2 Diabetes in Koreans

Insulin-Induced Electrophysiology Changes in Human Pleura Are Mediated via Its Receptor

Pleural Effusion Due to Use of Pioglitazone: A Case Report

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