Insulin adsorption by infusion sets in the setting of treatment of hyperkalaemia

Ng, Kai Xin; Yeo, Jillian Han Ting; Woo, Felicia Zuying; Wong, Jau Min; Sethi, Sunil; Loh, Tze Ping

doi:10.1007/s00508-015-0918-0

Cited by 2 publications

(3 citation statements)

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“…It is known that the regular insulin adsorbed to the surfaces of polyvinyl chloride (PVC) bags and infusion sets, which are generally used in hospitals, and not to the polypropylene (PP) surfaces. However, there are different data about the adsorption rates in the literature 9‐16 . Therefore, different approaches were implemented into the clinical practices, such as changing the bag every 4 or 12 hours, to minimise the adsorption of insulin to the bag during the infusion 17‐19 .…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of regular insulin adsorption to polypropylene bag and polyvinyl chloride infusion set

et al. 2020

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Aim Clinical application of insulin infusion therapy is usually accomplished with regular human insulin. It is known that the regular insulin adsorbed to the hydrophobic surfaces and different approaches were implemented into the clinical practices. It was aimed to evaluate the rate of adsorption of insulin to polypropylene (PP) bags and polyvinyl chloride (PVC) infusion sets and stability of insulin during the infusion. Methods A 100 IU insulin was added to PP bags containing 100 mL of 0.9% NaCl solution (n = 6). The infusion was started at a rate of 2 mL/h using infusion sets in the PVC structure. Insulin quantification was performed in the samples taken both from the bag and from the end tip of the infusion set during infusion. The stability of insulin solutions stored at room (+25°C) and refrigerator (+4°C) temperatures were compared. Samples were analysed using reverse‐phase high‐performance liquid chromatography. Results No statistically significant difference was found between the concentrations of the samples taken from the bags stored at room and refrigerator temperatures at the 4th, 12th, and 24th hours (P > .05). It was seen that the adsorption rate of insulin to PVC set was 57% and PP bags is at most 5% at the 24th hour. Conclusion When PP bags are used for insulin infusion, it is predicted that 24‐hour change can be made instead of frequent change. In addition, losses caused by the high rate of insulin adsorption to PVC infusion sets should be considered and PP infusion sets would be the better option to use if available.

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Section: Introductionmentioning

confidence: 99%

“…However, there are different data about the adsorption rates in the literature. [9][10][11][12][13][14][15][16] Therefore, different approaches were implemented into the clinical practices, such as changing the bag every 4 or 12 hours, to minimise the adsorption of insulin to the bag during the infusion. [17][18][19]…”

mentioning

confidence: 99%

Evaluation of regular insulin adsorption to polypropylene bag and polyvinyl chloride infusion set

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It is known that the regular insulin adsorbed to the surfaces of polyvinyl chloride (PVC) bags and infusion sets, which are generally used in hospitals, and not to the polypropylene (PP) surfaces. However, there are different data about the adsorption rates in the literature [9][10][11][12][13][14][15][16]. Therefore different approaches were implemented into the clinical practices, such as changing the bag every 4 or 12 hours, to minimize the adsorption of insulin to the bag during the infusion [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Regular Insulin Adsorption to Polypropylene Bag and Polyvinyl Chloride Infusion Set

Nenni²,

rat

et al. 2020

Preprint

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Aim Clinical application of insulin infusion therapy is usually accomplished with regular human insulin. It is known that the regular insulin adsorbed to the hydrophobic surfaces and different approaches were implemented into the clinical practices. It was aimed to evaluate the rate of adsorption of insulin to PP bags and PVC infusion sets and stability of insulin during the infusion. Methods 100 IU insulin was added to PP bags containing 100 ml of 0.9% NaCl solution(n = 6). The infusion was started at a rate of 2 ml/h using infusion sets in the PVC structure. Insulin quantification was performed in the samples taken both from the bag and from the end tip of the infusion set during infusion. The stability of insulin solutions stored at room (+24°C) and refrigerator (+4°C) temperatures were compared. Samples were analyzed using reverse-phase high-performance liquid chromatography. Results No statistically significant difference was found between the concentrations of the samples taken from the bags stored at room and refrigerator temperatures at the 4th, 12th, and 24th hours (p>0.05). It was seen that the adsorption rate of insulin to PVC set was 57% and PP bags is at most 5% at the 24th hour. Conclusion When PP bags are used for insulin infusion, it is predicted that 24-hour change can be made instead of frequent change. In addition, losses caused by the high rate of insulin adsorption to PVC infusion sets should be considered and PP infusion sets would be the better option to use if available.

show abstract

Insulin adsorption by infusion sets in the setting of treatment of hyperkalaemia

Cited by 2 publications

References 4 publications

Evaluation of regular insulin adsorption to polypropylene bag and polyvinyl chloride infusion set

Evaluation of regular insulin adsorption to polypropylene bag and polyvinyl chloride infusion set

Evaluation of Regular Insulin Adsorption to Polypropylene Bag and Polyvinyl Chloride Infusion Set

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